Reticap Capsule

Reticap Capsule 10 mg

Isotretinoin (brand name Accutane) is an oral pharmaceutical prescribed to treat acne. It is also very effective in treating skin diseases such as psoriasis. Isotretinoin works in severe cases of acne where other acne treatments have failed. It works by reducing oil production in the skin, which helps to reduce acne breakouts and inflammation.

Uses for

Isotretinoin is mainly used to treat severe acne that has not responded to other treatments. It can also be used to treat other skin conditions, such as psoriasis, as well as slow the progression of certain types of cancer.

Brand Name	Reticap
Type	Capsule
Weight	10 mg
Generic	Isotretinoin (Oral)
Manufacturer	UniMed UniHealth Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Isotretinoin works by decreasing the production of oil in the sebaceous glands, which helps to reduce acne breakouts and inflammation. It also reduces the growth of the bacteria that cause acne. Additionally, Isotretinoin helps to reduce the formation of comedones, which are the small bumps commonly seen in acne.

How Long Does It Take to Work ?

It typically take weeks to months to see visible results with isotretinoin. Depending on the person’s condition and response, treatment usually lasts around 4 to 6 months. However, it may take longer to treat more severe acne.

Absorption

Isotretinoin is rapidly absorbed after oral administration. It has an overall bioavailability of 70% and peak plasma concentrations are typically reached within 2 hours after administration.

Route of Elimination

Isotretinoin is metabolized in the liver and eliminated in the feces, urine, and sweat. It is also eliminated in the saliva and sebaceous glands.

Dosage

The capsules should be taken with food once or twice daily. Isotretinoin should only be prescribed by or under the supervision of physicians with expertise in the use of systemic retinoids for the treatment of severe acne and a full understanding of the risks of Isotretinoin therapy and monitoring requirements.

Adults including adolescents and the elderly: Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response to Isotretinoin and some of the adverse effects are dose-related and vary between patients. This necessitates individual dosage adjustment during therapy. For most patients, the dose ranges from 0.5-1.0 mg/kg per day. Long-term remission and relapse rates are more closely related to the total dose administered than to either duration of treatment or daily dose. It has been shown that no substantial additional benefit is to be expected beyond a cumulative treatment dose of 120-150 mg/kg. The duration of treatment will depend on the individual daily dose. A treatment course of 16-24 weeks is normally sufficient to achieve remission. In the majority of patients, complete clearing of the acne is obtained with a single treatment course. In the event of a definite relapse a further course of Isotretinoin therapy may be considered using the same daily dose and cumulative treatment dose. As further improvement of the acne can be observed up to 8 weeks after discontinuation of treatment, a further course of treatment should not be considered until at least this period has elapsed.

Patients with severe renal insufficiency: In patients with severe renal insufficiency treatment should be started at a lower dose (e.g. 10 mg/day). The dose should then be increased up to 1 mg/kg/day or until the patient is receiving the maximum tolerated dose.

Children: Isotretinoin is not indicated for the treatment of prepubertal acne and is not recommended in patients less than 12 years of age due to a lack of data on efficacy and safety.

Patients with intolerance: In patients who show severe intolerance to the recommended dose, treatment may be continued at a lower dose with the consequences of a longer therapy duration and a higher risk of relapse. In order to achieve the maximum possible efficacy in these patients the dose should normally be continued at the highest tolerated dose.

Isotretinoin is available as a brand name and generic version. The recommended dosage is based on the individual’s weight. The usual starting dose is 0.5 to 1 mg per kg of body weight taken once daily for a period of two to four months.

Administration

Isotretinoin is taken orally once daily with food or after meals. It is important to swallow the capsule whole with a full glass of water and to not crush, chew, or break the capsule.

Side Effect

The most common side effects of isotretinoin include dry skin, chapped lips, itchy skin, fatigue, dizziness, headaches, and joint pain. Additional side effects may include changes in vision, insomnia, depression, and decreased night vision.

Toxicity

Isotretinoin is considered safe when used as directed. However, overdose of isotretinoin can lead to serious side effects and medical attention should be sought immediately.

Precaution

Patients should not take isotretinoin if they are pregnant or planning to become pregnant, have liver disease or high cholesterol, or are allergic to any of the ingredients in the drug. Patients should also use a reliable form of contraception while taking isotretinoin and avoid excessive alcohol consumption. Patients should also not donate blood while taking isotretinoin.

Interaction

Isotretinoin may interact with other medications, such as tetracycline antibiotics or steroids. It is important to tell your doctor about all medications you are taking, including herbal remedies and over-the-counter medications, before taking isotretinoin.

Disease Interaction

Isotretinoin may interact with a variety of diseases such as diabetes, high cholesterol, and asthma. Patients with these conditions may need to be monitored more closely while taking isotretinoin.

Drug Interactions

Isotretinoin may interact with other medications, including tetracycline antibiotics and steroids. It is important to tell your doctor about all medications you are taking, including herbal remedies and over-the-counter medications, before taking isotretinoin.

Food Interactions

Isotretinoin may interact with foods rich in vitamin A, including liver, fish liver oils, and fortified milk. It is important to avoid eating large amounts of foods high in vitamin A while taking isotretinoin.

Pregnancy Use

Isotretinoin should not be used during pregnancy due to the risk of serious birth defects. Women of childbearing age should use birth control while taking isotretinoin and for one month after stopping the medication.

Lactation Use

It is not known if isotretinoin passes into breast milk. Women who are breastfeeding should not take isotretinoin.

Acute Overdose

An acute overdose of isotretinoin can lead to serious medical complications, such as nausea, vomiting, dizziness, and heart problems. If an overdose is suspected, seek immediate medical attention.

Contraindication

Isotretinoin is contraindicated in patients with a known hypersensitivity to it or any of its ingredients, and in pregnant or lactating women. It should also not be used in patients with liver disease or high cholesterol.

Use Directions

Isotretinoin capsules should be taken with food or after meals. Swallow the capsule whole with a full glass of water and do not crush, chew, or break the capsule. It is important to follow your doctor’s instructions when taking isotretinoin.

Storage Condition

Isotretinoin capsules should be stored at room temperature away from light and moisture. Keep the capsule in its original container and out of reach of children. Discard any unused capsules after the expiration date.