PM Plus Tablet

Introduction

PM Plus Tablet 500 mg+65 mg is a combination drug used for different types of pain and to reduce fever. It belongs to the group of drugs called analgesics and antipyretics. It is an over-the-counter medication available in multiple forms such as tablets, capsules, liquids, suspensions and injections.

Uses of PM Plus Tablet 500 mg+65 mg

PM Plus Tablet 500 mg+65 mg is commonly used for relief from mild to moderate pain, such as headaches, muscle aches, dental pain, menstrual cramps, and flu. It is also used for reducing fever and as a nighttime sleep aid.

Mechanism of Action

Paracetamol is a centrally acting analgesic and antipyretic. It works by inhibiting the synthesis of substances called prostaglandins in the brain and spinal cord. These prostaglandins are involved in the transmission of pain signals to the brain. Caffeine works by constricting the blood vessels and increasing the pain threshold, thus decreasing the pain perception in the brain.

How Long Does It Take To Work?

PM Plus Tablet 500 mg+65 mg usually starts to work within 20-30 minutes when taken orally. Its effect can last up to 6 hours.

Absorption

PM Plus Tablet 500 mg+65 mg is rapidly and nearly completely absorbed from the gastrointestinal tract.

Route of Elimination

PM Plus Tablet 500 mg+65 mg is primarily eliminated through the kidneys, where it is metabolized to inactive metabolites which are then excreted in the urine.

Dosage

The usual dose of PM Plus Tablet 500 mg+65 mg is one or two tablets or capsules every 4-6 hours. The maximum dose in 24 hrs is 8 tablets or capsules. It is advised to not exceed the maximum dose as it can cause side effects.

Administration

PM Plus Tablet 500 mg+65 mg should be taken orally, with or without food. It can be taken with a glass of water.

Side Effect

• Nausea
• Vomiting
• Stomach pain
• Headache
• Dizziness
• Rash

Toxicity

Overdose of PM Plus Tablet 500 mg+65 mg can lead to serious side effects such as liver and kidney damage. Taking more than the recommended dose can also cause poisoning and can be fatal.

Precaution

• Patients with liver or kidney disease, asthma, high blood pressure, or heart diseases should not use PM Plus Tablet 500 mg+65 mg
• Women who are pregnant or breastfeeding should avoid the use of this medication.

Interaction

PM Plus Tablet 500 mg+65 mg can interact with other medications, such as anticoagulants and antidiabetic drugs, and increase the risk of side effects. It can also interact with alcohol and increases the risk of liver damage.

Disease Interaction

PM Plus Tablet 500 mg+65 mg can interact with certain conditions and worsen the symptoms, such as liver or kidney disease, asthma, high blood pressure, and heart diseases.

Drug Interaction

PM Plus Tablet 500 mg+65 mg can interact with other drugs and increase the risk of side effects. These drugs include anticoagulants, diuretics, and antidiabetic drugs.

Food Interactions

Foods such as alcohol, grapefruit juice, caffeine-containing drinks, and spicy foods may interact with PM Plus Tablet 500 mg+65 mg and increase the risk of side effects.

Pregnancy Use

PM Plus Tablet 500 mg+65 mg should be avoided during pregnancy, as its safety has not yet been established.

Lactation Use

It is not recommended to take PM Plus Tablet 500 mg+65 mg while breastfeeding, as its safety has not yet been established.

Acute Overdose

Acute overdose of PM Plus Tablet 500 mg+65 mg can cause severe symptoms such as nausea, vomiting, abdominal pain, drowsiness, sweating and confusion. It can also lead to liver and kidney damage.

Contraindication

PM Plus Tablet 500 mg+65 mg should not be taken in case of hypersensitivity to any of its components. Also, it is contraindicated in patients with certain medical conditions such as liver or kidney diseases, asthma, high blood pressure, and heart diseases.

Use Direction

As recommended by the doctor, PM Plus Tablet 500 mg+65 mg should be taken every 4-6 hours for relief from pain or fever. It can be taken with or without food.

Storage Condition

PM Plus Tablet 500 mg+65 mg should be stored at room temperature away from direct sunlight, moisture, and heat. Keep out of reach of children.

Volume of Distribution

The volume of distribution of PM Plus Tablet 500 mg+65 mg is not known.

Half Life

The half life of PM Plus Tablet 500 mg+65 mg is 3-4 hours.

Clearance

The clearance of PM Plus Tablet 500 mg+65 mg in the body is not known.

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Some Frequently Asked Questions About PM Plus Tablet 500 mg+65 mg

1. What is PM Plus Tablet 500 mg+65 mg?

PM Plus Tablet 500 mg+65 mg is a combination drug used to relieve pain, reduce fever, and sometimes enhance the effectiveness of the pain-relieving action of Paracetamol.

2. How does PM Plus Tablet 500 mg+65 mg work?

Paracetamol works by inhibiting the production of prostaglandins, chemicals that promote pain and fever. Caffeine acts as a mild stimulant, increasing the effectiveness of Paracetamol in relieving pain.

3. What conditions does PM Plus Tablet 500 mg+65 mg treat?

This combination is often used to treat:

• Headaches
• Migraines
• Muscle aches
• Arthritis
• Back pain
• Toothaches
• Cold symptoms
• Fever

4. How does caffeine enhance Paracetamol's effects?

Caffeine enhances the absorption of Paracetamol, helping it to work faster and more effectively in treating pain.

5. What is the usual dosage for PM Plus Tablet 500 mg+65 mg?

The usual dosage for adults is one or two tablets every 4 to 6 hours, not exceeding 4 tablets within 24 hours. Always follow the label instructions or your healthcare provider's guidance.

6. Can PM Plus Tablet 500 mg+65 mg be used during pregnancy?

Paracetamol is generally considered safe during pregnancy, but caffeine should be limited. It's important to consult a healthcare provider before using this combination during pregnancy.

7. Is PM Plus Tablet 500 mg+65 mg safe for breastfeeding mothers?

Paracetamol is considered safe during breastfeeding, but caffeine passes into breast milk. It is important to limit caffeine intake and consult your healthcare provider for advice.

8. What are the side effects of PM Plus Tablet 500 mg+65 mg?

Common side effects include:

• Restlessness or jitteriness (from caffeine)
• Increased heart rate
• Upset stomach
• Allergic reactions (rare)

9. Can I take PM Plus Tablet 500 mg+65 mg with alcohol?

It is not recommended to take this combination with alcohol, as alcohol can increase the risk of liver damage from Paracetamol and may exacerbate caffeine's stimulating effects.

10. How often can I take PM Plus Tablet 500 mg+65 mg?

You can take PM Plus Tablet 500 mg+65 mg every 4 to 6 hours, but it should not exceed 4 doses in 24 hours to avoid the risk of overdose and side effects.

11. Can PM Plus Tablet 500 mg+65 mg cause dependence?

Caffeine in this combination may lead to mild dependence if taken frequently, but it is not typically addictive in the amounts found in PM Plus Tablet 500 mg+65 mg tablets.

12. Can children take PM Plus Tablet 500 mg+65 mg?

This combination is generally not recommended for children under 12 years old without a doctor's recommendation. Always consult a healthcare provider for age-specific dosing.

13. How does caffeine in PM Plus Tablet 500 mg+65 mg affect the body?

Caffeine is a stimulant that can increase alertness, reduce fatigue, and improve mood. It may also help to alleviate headache pain by constricting blood vessels.

14. Can I take PM Plus Tablet 500 mg+65 mg for a migraine?

Yes, PM Plus Tablet 500 mg+65 mg is commonly used to treat migraines. The caffeine can help enhance the pain-relieving effects of Paracetamol and provide faster relief.

15. What should I do if I overdose on PM Plus Tablet 500 mg+65 mg?

If you overdose, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, confusion, stomach pain, restlessness, and increased heart rate.

16. Is PM Plus Tablet 500 mg+65 mg effective for tension headaches?

Yes, this combination can help relieve tension headaches by reducing pain and providing a stimulating effect to combat fatigue.

17. Can I take PM Plus Tablet 500 mg+65 mg with other medications?

It's important to consult your doctor or pharmacist before taking PM Plus Tablet 500 mg+65 mg with other medications, especially those that also contain caffeine or affect the liver.

18. Does PM Plus Tablet 500 mg+65 mg help with fever?

Yes, PM Plus Tablet 500 mg+65 mg can reduce fever. Paracetamol helps lower the body temperature, and caffeine helps speed up the action of Paracetamol.

19. Can I take PM Plus Tablet 500 mg+65 mg for back pain?

Yes, this combination can be effective for relieving mild to moderate back pain by reducing inflammation and promoting pain relief.

20. Does PM Plus Tablet 500 mg+65 mg work faster than Paracetamol alone?

Yes, caffeine can speed up the absorption of Paracetamol, allowing it to take effect more quickly in relieving pain.

21. Can I take PM Plus Tablet 500 mg+65 mg if I have high blood pressure?

Caffeine can raise blood pressure, so individuals with high blood pressure should consult a doctor before taking PM Plus Tablet 500 mg+65 mg, especially on a regular basis.

22. How should I store PM Plus Tablet 500 mg+65 mg?

Store PM Plus Tablet 500 mg+65 mg in a cool, dry place, away from heat and moisture. Keep it out of reach of children.

23. Is PM Plus Tablet 500 mg+65 mg safe for elderly individuals?

Elderly individuals can generally take PM Plus Tablet 500 mg+65 mg, but the caffeine component should be considered, as it may cause restlessness or insomnia. Always consult a doctor for advice on dosage.

24. Can I take PM Plus Tablet 500 mg+65 mg for a toothache?

Yes, PM Plus Tablet 500 mg+65 mg can be used for temporary relief of toothache pain. However, it is important to see a dentist for the underlying cause.

25. What happens if I miss a dose of PM Plus Tablet 500 mg+65 mg?

If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Never take two doses at once.

26. Can I take PM Plus Tablet 500 mg+65 mg for muscle pain?

Yes, PM Plus Tablet 500 mg+65 mg can help alleviate mild to moderate muscle pain by reducing pain and promoting faster absorption.

27. Can PM Plus Tablet 500 mg+65 mg be used for hangover relief?

PM Plus Tablet 500 mg+65 mg can help alleviate headache and body pain associated with a hangover. However, it is important to avoid taking this combination with alcohol to prevent liver damage.

28. Can I take PM Plus Tablet 500 mg+65 mg with food?

Yes, PM Plus Tablet 500 mg+65 mg can be taken with or without food. However, taking it with food may help reduce stomach irritation.

29. How long does PM Plus Tablet 500 mg+65 mg take to work?

PM Plus Tablet 500 mg+65 mg usually starts to work within 30 minutes to 1 hour, with maximum effect occurring in 1 to 2 hours.

30. Does PM Plus Tablet 500 mg+65 mg help with sinus pain?

Yes, this combination can help relieve sinus pain by reducing inflammation and providing temporary pain relief.

31. Can I take PM Plus Tablet 500 mg+65 mg for a cold or flu?

PM Plus Tablet 500 mg+65 mg can help relieve the pain and fever associated with a cold or flu, but it does not cure the viral infection itself.

32. What should I do if I feel jittery after taking PM Plus Tablet 500 mg+65 mg?

If you experience jitteriness, restlessness, or other symptoms of caffeine overdose, try drinking water, relaxing, and avoiding further caffeine intake. If symptoms persist, consult a healthcare provider.

33. Can PM Plus Tablet 500 mg+65 mg cause insomnia?

Yes, the caffeine in this combination can cause difficulty sleeping, especially if taken late in the day. Avoid taking it close to bedtime.

34. Can I take PM Plus Tablet 500 mg+65 mg for menstrual cramps?

Yes, PM Plus Tablet 500 mg+65 mg can help relieve pain associated with menstrual cramps, reducing discomfort and promoting faster pain relief.

35. Is PM Plus Tablet 500 mg+65 mg addictive?

While caffeine can be habit-forming in large quantities, the doses in PM Plus Tablet 500 mg+65 mg are not typically enough to cause addiction.

36. Can PM Plus Tablet 500 mg+65 mg help with a stiff neck?

Yes, this combination can help alleviate pain from a stiff neck by reducing pain and providing muscle relaxation.

37. Can PM Plus Tablet 500 mg+65 mg cause liver damage?

Excessive use of Paracetamol can cause liver damage. Always follow the recommended dosage and consult your doctor if you have liver disease.

38. Can I take PM Plus Tablet 500 mg+65 mg with other pain medications?

It's important to consult your healthcare provider before combining PM Plus Tablet 500 mg+65 mg with other pain medications to avoid overdose or interactions.

39. Is PM Plus Tablet 500 mg+65 mg available over the counter?

Yes, PM Plus Tablet 500 mg+65 mg is available over-the-counter without a prescription at most pharmacies and drugstores.

40. Can I take PM Plus Tablet 500 mg+65 mg for a backache?

Yes, PM Plus Tablet 500 mg+65 mg can be effective for relieving mild to moderate backache pain by reducing inflammation and alleviating discomfort.

41. Does PM Plus Tablet 500 mg+65 mg interact with other medications?

PM Plus Tablet 500 mg+65 mg may interact with other medications, including those for blood pressure, blood thinners, and certain antidepressants. Always check with a healthcare provider before combining drugs.

42. Can PM Plus Tablet 500 mg+65 mg cause dizziness?

While not common, caffeine can cause dizziness in some people. If you experience dizziness, stop using the medication and consult your doctor.

43. Can PM Plus Tablet 500 mg+65 mg be used for a hangover headache?

Yes, it can help alleviate hangover headaches, but you should ensure you stay hydrated and avoid further alcohol consumption.

44. Can PM Plus Tablet 500 mg+65 mg cause nausea?

Nausea is a possible side effect of caffeine. If you experience nausea, reduce caffeine intake and consult your healthcare provider.

45. Can PM Plus Tablet 500 mg+65 mg help with chronic pain?

PM Plus Tablet 500 mg+65 mg is intended for short-term pain relief and is not recommended for chronic pain management. Consult a doctor for chronic pain treatment options.

46. Can I take PM Plus Tablet 500 mg+65 mg with food to prevent stomach upset?

Yes, taking PM Plus Tablet 500 mg+65 mg with food may help reduce the risk of stomach irritation or discomfort.

47. Does PM Plus Tablet 500 mg+65 mg treat tooth pain?

Yes, this combination can temporarily relieve tooth pain, but it is important to consult a dentist for long-term solutions.

48. How long can I safely use PM Plus Tablet 500 mg+65 mg?

It is recommended for short-term use only. If pain persists for more than a few days, consult a doctor for further evaluation.

49. Can I take PM Plus Tablet 500 mg+65 mg with herbal supplements?

Before combining with herbal supplements, check with your healthcare provider, as certain herbs can interact with caffeine and Paracetamol.

50. Is PM Plus Tablet 500 mg+65 mg effective for tension headaches?

Yes, PM Plus Tablet 500 mg+65 mg is effective for relieving the pain associated with tension headaches and can provide faster relief than Paracetamol alone.