Pegaron Capsule

Pegaron Capsule 25 mg Introduction

Pegaron Capsule 25 mg is an anticonvulsant medication used to control epilepsy, relieve pain, and treat a range of anxiety and neuropathic pain conditions. It is in the class of drugs known as alpha2-delta ligands and is one of the most commonly prescribed anticonvulsant agents.

Uses Of Pegaron Capsule 25 mg

Pegaron Capsule 25 mg is primarily used to treat nerve pain, neuropathic pain, seizures, diabetic neuropathy, fibromyalgia, restless leg syndrome, and in some cases, anxiety disorders. It is also used to reduce the symptoms of opioid withdrawal and alcohol withdrawal.

Brand Name	Pegaron
Type	Capsule
Weight	25 mg
Generic	Pregabalin
Manufacturer	Jenphar Bangladesh Ltd.
Available in	English বাংলা

Mechanism of Action

Pegaron Capsule 25 mg works by reducing the release of neurotransmitters in the brain that cause pain and anxiety. Specifically, it works on the alpha2-delta type ligands, which are tiny proteins that bind to certain receptors in the brain. Pegaron Capsule 25 mg binds to these receptors and helps reduce the amount of neurotransmitters released from cells, leading to a decrease in nerve activity. This, in turn, helps decrease pain and improve mood.

How Long Does it Take to Work?

The effects of pregabalin begin within one week but may vary depending on the dosage, condition, and individual response. Generally, most people start to experience pain relief within the first three to four weeks of taking pregabalin.

Absorption

Pegaron Capsule 25 mg is rapidly absorbed following oral administration with peak concentrations occurring within 1-2 hours. It is mainly metabolized to inactive metabolites and is renally excreted.

Route of Elimination

Pegaron Capsule 25 mg is eliminated primarily via the kidneys, with an estimated 25-33% of a dose excreted unchanged in the urine. It is not metabolized to any appreciable extent, and its elimination half-life is approximately 6.3 hours.

Dosage

The recommended dosage of pregabalin for treating pain is 150 to 600 mg per day in three or four divided doses (75 to 225 mg twice a day, or 75 to 300 mg three times a day). The dosage range for treating seizures is 150 to 600 mg per day, divided into two or three doses.

Administration

Pegaron Capsule 25 mg can be taken orally or injected intramuscularly. It is typically administered in either capsule or tablet form. Other forms may also be available, such as liquid or injection.

Side Effects

The most common side effects of pregabalin include drowsiness, dizziness, insomnia, swelling of the hands and feet, dry mouth, blurred vision, and changes in appetite. Less common side effects include weight gain, depression, nausea, constipation, heartburn, and nausea. In rare cases, it may also cause serious allergic reactions. More serious side effects can include low blood pressure, confusion, and difficulty breathing.

Toxicity

Pegaron Capsule 25 mg is thought to be low in toxicity when taken as prescribed. However, large doses or long-term use can result in serious side effects, including decreased muscle coordination, coma, and kidney failure. Overdosing can also result in serious injury or death.

Precautions

It is important to tell your doctor about any medical conditions you may have, as well as other medications or supplements you are taking. Pegaron Capsule 25 mg should not be taken in combination with certain substances, such as alcohol, as this may increase the risk of side effects. Pegaron Capsule 25 mg can also cause dizziness or sleepiness, which may increase the risk of falling.

Interactions

Pegaron Capsule 25 mg may interact with a variety of medications, including anticonvulsants, NSAIDs, mirtazapine, gabapentin, and certain antibiotics. It is also important to tell your doctor about any over-the-counter medications or supplements you are taking as they may interact with pregabalin.

Drug Interactions

Pegaron Capsule 25 mg can interact with many other drugs, including certain antidepressants, anticonvulsants, anti-anxiety medications, muscle relaxants, narcotic analgesics, sleep aids, and antibiotics. It is important to tell your doctor about all medications and supplements you are taking as they may interact with pregabalin.

Food Interactions

Pegaron Capsule 25 mg should be taken with food to increase its absorption. Taking pregabalin with grapefruit juice and grapefruit products may increase the risk of side effects. It is also important to tell your doctor if you are taking any herbal supplements.

Pregnancy Use

Pegaron Capsule 25 mg is generally not recommended during pregnancy due to limited safety data. However, it may be prescribed if the potential benefits outweigh the potential risks. Women who are pregnant or planning to become pregnant should consult their doctor before taking pregabalin.

Lactation Use

Pegaron Capsule 25 mg is excreted into breast milk and should be used cautiously in breastfeeding mothers. Breastfeeding mothers should consult their doctor before taking pregabalin.

Acute Overdose

An acute overdose of pregabalin can cause symptoms such as drowsiness, confusion, slowed breathing, and unconsciousness. If you think you or someone you know has taken too much pregabalin, contact your doctor or a poison control center immediately.

Contraindication

Pegaron Capsule 25 mg is contraindicated in patients with a known hypersensitivity to pregabalin or any of its components. It is also contraindicated in patients with severe hepatic or renal impairment.

Use Direction

Pegaron Capsule 25 mg should be taken exactly as directed by your doctor. Do not take more or less than the prescribed dose and do not stop taking pregabalin without consulting your doctor.

Storage Condition

Pegaron Capsule 25 mg should be stored at room temperature away from light and moisture. It should also be kept out of the reach of children and pets.