Ornidazole

Introduction

Ornidazole is an antibiotic drug used to treat certain infections caused by bacteria, such as trichomonas, anaerobic bacteria, and protozoa. It is also sometimes used to treat urinary tract infections and skin and soft tissue infections. Ornidazole works by interfering with the cell membranes of the bacteria and preventing them from growing and multiplying.

Uses For

Ornidazole is primarily used to treat infections caused by trichomonas, anaerobic bacteria, and protozoa. It is used to treat vaginal, urinary tract, gastrointestinal, skin and soft tissue infections.

Brand Name	Ornidazole
Type
Weight
Generic	Ornidazole
Manufacturer
Available in	English বাংলা

Mechanism of Action

Ornidazole works by interfering with the cell membrane of the bacteria, preventing them from growing and multiplying. This prevents the bacteria from producing their own proteins and from replicating. As a result, the bacteria are destroyed and the infection is cleared up.

How Long Does It Take to Work?

Ornidazole typically starts to take effect within a few days of treatment. However, it may take up to a few weeks for symptoms to completely clear up.

Absorption

Ornidazole is absorbed from the gastrointestinal tract and rapidly metabolized in the liver. The drug is not significantly bound to plasma proteins.

Route of Elimination

Ornidazole is eliminated mainly by metabolism in the liver and subsequent renal excretion of its metabolites. It is also mildly eliminated via biliary excretion.

Dosage

Amoebiasis:

• Adults: 500 mg twice a day for 5 days.
• Children: 10-25 mg per kg body weight in two divided doses.

Amoebic dysentery:

• Adults: 1.5 gm once a day for 3 days.
• Children: 40 mg per kg body weight, once a day for 3 days.

Giardiasis:

• Adults: 1.5 gm once daily for 1-2 days.
• Children: 40 mg per kg body weight for 2 days.

Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.

Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.

The usual adult dose of Ornidazole is 500 mg twice daily for 7-14 days. Children should take 5 mg/kg/day (maximum 500 mg/day) divided twice daily for 10-14 days. Dosage may be adjusted for patients with renal impairment.

Administration

Ornidazole should be taken with a full glass of water. It is covered and should be taken on an empty stomach, at least one hour before or two hours after meals.

Side Effects

The most common side effects of Ornidazole include nausea, vomiting, abdominal pain, diarrhea, loss of appetite, and headache. Other side effects may include rash, itching, dizziness, and joint pain.

Toxicity

Ornidazole can be toxic if taken in excess; high doses can cause nausea, vomiting, abdominal pain, and diarrhea. Overdose can lead to liver damage and other serious health complications.

Precaution

Ornidazole should not be used by patients with renal impairment or by pregnant women. It should also not be used by patients who are hypersensitive to nitroimidazoles or pediatric patients younger than 6 years old. Before taking Ornidazole , patients should inform their doctor about any other medications they may be taking.

Interaction

Ornidazole can interact with other medications, including anticoagulants, cimetidine, and certain antacids. Drugs that reduce stomach acid can reduce the absorption of Ornidazole . Alcohol should also not be consumed while taking Ornidazole .

Disease Interaction

Ornidazole may not be suitable for some people, such as those with liver or kidney disease. It can also interact with certain diseases, such as systemic lupus erythematosus or porphyria, so it is important to inform your doctor if you have any pre-existing conditions.

Drug Interaction

Ornidazole can interact with other drugs, such as anticoagulants, cimetidine, and certain antacids. It may also interact with alcohol, so it is important to avoid drinking alcohol while taking Ornidazole .

Food Interactions

Ornidazole can interact with certain foods, so it is important to check with your doctor before consuming any food while taking this medication. Foods that can interact with Ornidazole include fortified milk, certain dairy products, and certain antacids.

Pregnancy Use

Ornidazole is not recommended for use in pregnant women. It should only be used if the potential benefits outweigh the potential risks, and only under the guidance of a qualified doctor.

Lactation Use

Ornidazole has not been studied in nursing mothers, so its safety in this population is not known. It should be used with caution and only under the guidance of a qualified doctor.

Acute Overdose

Symptoms of an overdose include nausea, vomiting, abdominal pain, and diarrhea. It is important to seek immediate medical attention if an overdose is suspected.

Contraindication

Ornidazole is contraindicated for use in patients with renal impairment, those who are hypersensitive to nitroimidazoles, and pediatric patients younger than 6 years old.

Use Direction

Ornidazole should be taken as directed by your doctor. The usual adult dose is 500 mg twice daily for 7-14 days. Children should take 5 mg/kg/day (maximum 500 mg/day) divided twice daily for 10-14 days. Dosage may be adjusted for patients with renal impairment.

Storage Condition

Ornidazole should be stored at room temperature, away from light and moisture. Keep out of reach of children and pets.

Volume of Distribution

The volume of distribution of Ornidazole is 0.37 L/kg.

Half Life

The half-life of Ornidazole is 2 to 4 hours.

Clearance

The clearance of Ornidazole is 0.95 mL/min/kg.

See in details version Ornidazole also Ornidazole in bangla

Some Frequently Asked Questions About Ornidazole