Introduction
Oratics Dental Gel 20% w/w is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products. Oratics Dental Gel 20% w/w was first used for local anesthesia in dentistry.
Uses
Oratics Dental Gel 20% w/w is a topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.
Oratics Dental Gel 20% w/w is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia. Oratics Dental Gel 20% w/w products are indicated for topical anesthesia in a wide variety of conditions including skin irritation, oral pain, and hemorrhoids.
Associated Conditions
Pharmacodynamics
Oratics Dental Gel 20% w/w is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
Mechanism of Action
Oratics Dental Gel 20% w/w diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses.
Protein Binding
Oratics Dental Gel 20% w/w binds to both serum albumin and alpha-1-acid glycoprotein.
Toxicity
Patients experiencing an overdose may present with local anesthetic systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac arrest, bradycardia, hypotension, cardiac arrhythmias, syncope, and seizures. Patients should be treated with symptomatic and supportive measures which include airway maintenance, controlling seizures, and hemodynamic stabilization.
Food Interactions
No interactions found.
