Olodin DS Ophthalmic Solution

Introduction

Olopatadine hydrochloride is an antihistamine drug that relieves the symptoms of seasonal and perennial allergic rhinitis (hay fever and other allergies) by blocking histamine that causes sneezing, itchiness, and tears. It is currently available as ophthalmic solutions and intranasal sprays.

Uses

Olopatadine hydrochloride is used to treat allergic rhinitis and allergic eye symptoms such as itching, redness, tearing, and burning. It is also used to treat allergic skin reactions.

Mechanism Of Action

Olopatadine hydrochloride is an antihistamine which works by blocking the action of histamine. By blocking the activity of histamine, it reduces the symptoms of allergies such as sneezing, itching, watery eyes, and congestion.

How Long Does It Take to Work?

Olopatadine hydrochloride typically takes several hours to take effect, and its full effects may not be felt for up to 24 hours.

Absorption

Olopatadine hydrochloride is rapidly and nearly completely absorbed from the eye through the mucous membranes.

Route of Elimination

Olopatadine hydrochloride is eliminated primarily through metabolism in the liver, and only a small amount is excreted unchanged in the urine.

Dosage

Eye Drops-

0.1%: One drop in each affected eye two times per day at an interval of 6 to 8 hours.
0.2%: One drop in the affected eye once a day.
0.7%: One drop in each affected eye once a day.

Nasal Spray-

Administer Olopatadine Nasal Spray by the intranasal route only.
Adults and Adolescents 12 years of age and older: Two sprays per nostril twice daily.\
Children 6 to 11 years of age: One spray per nostril twice daily.

Tablet-

Adults: Take 1 tablet (5 mg of the active ingredient) at a time, twice daily, in the morning and before going to bed. The dosage may be adjusted according to the disease, age or symptoms.
Children 7 years old or over: Take 1 tablet (5 mg) at a time, twice daily, in the morning and before going to bed.
If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time. Do not stop taking this medicine unless your doctor instructs you to do so.

For intranasal use, the recommended dose for adults is one or two sprays of either 0.1% or 0.6% olopatadine hydrochloride intranasal spray per nostril once or twice daily.

Administration

Olopatadine hydrochloride is typically administered to the eye(s) or intranasally. It should not be administered intravenously or orally.

Side Effect

The most common side effects of olopatadine hydrochloride include redness, stinging, burning, itching, eye pain, increased tear production, and blurred vision.

Toxicity

There is no information available on the toxicity of olopatadine hydrochloride.

Precaution

Patients should inform their doctor if they are pregnant, breastfeeding, or have any other medical conditions. Olopatadine hydrochloride should not be used by patients with glaucoma or any other eye conditions, or in patients taking monoamine oxidase inhibitors.

Interaction

Olopatadine hydrochloride may interact with certain medications. Patients should inform their doctor if they are taking other medications before using olopatadine hydrochloride.

Disease Interactions

Olopatadine hydrochloride may interact with certain medical conditions. Patients should inform their doctor if they have any medical conditions before using olopatadine hydrochloride.

Drug Interactions

Olopatadine hydrochloride may interact with certain drugs. Patients should inform their doctor if they are taking any other drugs before using olopatadine hydrochloride.

Food Interactions

Food interactions have not been established.

Pregnancy Use

Olopatadine hydrochloride should not be used by pregnant women.

Lactation Use

Olopatadine hydrochloride should not be used while breastfeeding.

Acute Overdose

An acute overdose of olopatadine hydrochloride is unlikely to occur, since olopatadine hydrochloride is poorly absorbed when taken orally.

Contraindication

Olopatadine hydrochloride is contraindicated in patients with glaucoma, any other eye conditions, or in patients taking monoamine oxidase inhibitors.

Use Direction

The recommended adult dosage for olopatadine hydrochloride is one or two drops of either 0.2% Olodin DS Ophthalmic Solution 0.2% ophthalmic solution or 0.6% Olodin DS Ophthalmic Solution 0.2% ophthalmic solution applied to the affected eye(s) once or twice daily. For intranasal use, the recommended dose for adults is one or two sprays of either 0.1% or 0.6% olopatadine hydrochloride intranasal spray per nostril once or twice daily.