Nintoin Capsule

Introduction

Nintoin Capsule 50 mg is an antibiotic medication used primarily to treat bladder infections. It's used to treat most types of urinary tract infections in both adults and children. It works by stopping bacteria from growing in the bladder and urinary system.

Uses of Nintoin Capsule 50 mg

Nintoin Capsule 50 mg is used to treat urinary tract infections, including cystitis and bladder infections. It is also used to prevent recurrence of these infections.

Brand Name	Nintoin
Type	Capsule
Weight	50 mg
Generic	Nitrofurantoin
Manufacturer	Incepta Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Nintoin Capsule 50 mg works by inhibiting bacterial enzymes essential for the synthesis of DNA and cell wall production. This prevents bacteria from producing new cells and stops their growth.

How Long Does It Take to Work?

Nintoin Capsule 50 mg usually takes 2 to 3 days to start working. Some people may notice improvement after only one day.

Absorption

Nintoin Capsule 50 mg is only partially and slowly absorbed into the blood after being taken orally. Its concentration in the blood is typically low.

Route of Elimination

Nintoin Capsule 50 mg is primarily eliminated in urine. It is excreted in the urine as a mixture of unchanged drug and its metabolites.

Dosage

Nitrofurantoin tablet (In adults):

Uncomplicated urinary tract infections: 50-100 mg four times a day- the lower dosage level is recommended. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy: In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate.

Nitrofurantoin capsule (In adults):

Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for 7 days.
Long term suppression: 50-100 mg once a day.
Prophylaxis: 50 mg four times daily for the duration of procedure and for three days thereafter.

Nitrofurantoin SR capsule:

Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days.
Genito-urinary surgical prophylaxis: One capsule twice daily on day of procedure and for next 3 days.

Nitrofurantoin suspension: Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). The average dose of Nintoin suspension for pediatric patients are as follows-

7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily.
12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily.
22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily.
31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily.

Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.

Nintoin Capsule 50 mg is available in the form of tablets, capsules, and suspension. It is usually taken two or three times a day for 5 to 10 days, depending on the severity of the infection.

Adults and children 12 years and over: 100 mg twice a day for 7 days.
Children 11 years and younger: 5 mg/kg/day (up to a maximum of 100 mg/day) for 7 days.

Administration

Nintoin Capsule 50 mg should be taken at least 2 hours after eating and on an empty stomach. It should also be taken with plenty of fluids to help reduce the risk of crystals forming in the urine.

Side Effects

Common side effects of nitrofurantoin include nausea, vomiting, headache, fever, rash, and abdominal pain. It can also cause diarrhea and changes in blood tests.

Toxicity

Nintoin Capsule 50 mg is generally well tolerated and has a low risk of toxicity. However, overdose or misuse can lead to serious side effects such as kidney damage and anemia.

Precautions

It is important to follow your doctor's instructions when taking nitrofurantoin. Do not take more than your prescribed dose and take it with plenty of fluids to reduce the risk of kidney stones forming.

Interactions

Nintoin Capsule 50 mg may interact with certain medications, herbal supplements, and vitamins. Before taking this medication, be sure to tell your doctor about all the medications you are taking.

Disease Interactions

Nintoin Capsule 50 mg may interact with certain chronic medical conditions such as chronic kidney disease or anemia. It is important to tell your doctor about any chronic conditions before taking this medication.

Drug Interactions

Nintoin Capsule 50 mg may interact with common medications such as antacids, laxatives, and vitamins. Be sure to tell your doctor about all the medications you are taking before taking this medication.

Food Interactions

Nintoin Capsule 50 mg should be taken on an empty stomach. It should not be taken with food or milk.

Pregnancy Use

Nintoin Capsule 50 mg should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. It is important to discuss the risks and benefits of taking this medication with your doctor.

Lactation Use

It is not known if nitrofurantoin passes into breast milk. Therefore, it should be used with caution in nursing mothers.

Acute Overdose

An overdose of nitrofurantoin can lead to serious side effects, including kidney damage and anemia. If you think you have taken too much of this medication, seek medical help immediately.

Contraindications

Nintoin Capsule 50 mg should not be used in people with certain conditions such as kidney disease, anemia, certain blood disorders, and allergies to nitrofurantoin or similar medications.

Use Directions

Nintoin Capsule 50 mg should be taken with plenty of fluids to prevent kidney stones forming and should be taken on an empty stomach, at least 2 hours after eating. It should be used for the full prescribed amount of time.

Storage Conditions

Nintoin Capsule 50 mg should be stored in a cool, dry place away from direct light or moisture. Keep the container tightly closed and away from children.