Brand Name Netis
Type Oral Solution
Weight 2.5 mg/5 ml
Generic Levocetirizine Dihydrochloride
Manufacturer Opsonin Pharma Ltd.
Price (Bangladesh) 60 ml bottle: ৳ 55.00
Available in

About Netis Oral Solution 2.5 mg/5 ml

Netis Oral Solution 2.5 mg/5 ml is a brand medicine manufactured by Opsonin Pharma Ltd. containing the generic Levocetirizine Dihydrochloride (2.5 mg/5 ml). Current listed price in Bangladesh: 60 ml bottle: ৳ 55.00.

Medical information for Netis Oral Solution 2.5 mg/5 ml

Uses, dosage, side effects, and safety details below apply to Netis Oral Solution 2.5 mg/5 ml (generic: Levocetirizine Dihydrochloride). This is general information — consult a doctor before use.

Introduction

Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms. It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine.

Uses

Levocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.

Levocetirizine is indicated to treat symptoms of perennial allergic rhinitis and uncomplicated skin manifestations of chronic idiopathic urticaria. It is also used over the counter for a variety of mild allergy symptoms.

Associated Conditions

  • Allergic Rhinitis (AR)
  • Chronic Idiopathic Urticaria
  • Common Cold
  • Nasal Congestion
  • Perennial Allergic Rhinitis (PAR)
  • Seasonal Allergic Rhinitis

Pharmacodynamics

Levocetirizine is a second generation histamine H1 antagonist used to treat various allergic symptoms. It has a long duration of action as it is generally taken once daily, and a wide therapeutic window as animal studies show the maximal nonlethal dose is over 100x a normal dose. Patients are cautioned to avoid tasks that require complete alertness, avoid alertness, and use caution in patients with factors predisposing urinary retention.

Mechanism of Action

Levocetirizine selectively inhibits histamine H1 receptors. This action prevents histamine from activating this receptor and causing effects like smooth muscle contraction, increased permeability of vascular endothelium, histidine uptake in basophils, stimulation of cough receptors, and stimulation of flare responses in the nervous system.

Absorption

Following a 5mg oral dose of levocetirizine, a Cmax of 0.27±0.04µg/mL with a Tmax of 0.75±0.50h. The AUC of levocetirizine is 2.31±0.50µg*h/mL. Taking levocetirizine with food does not affect the AUC but delays Tmax by 1.25 hours and lowers Cmax by 36%.

Volume of Distribution

The volume of distribution of levocetirizine is 0.33±0.02L/kg.

Protein Binding

Plasma protein binding of levocetirizine was on average 96.1% 1 hour post dose and 91.9% 6 hours post dose.

Route of Elimination

168 hours post dose an average of 85.4% of a radiolabeled dose was recovered with an average of 80.8% in the urine and 9.5% in the feces. In the urine, 77% of the dose was recovered as unchanged drug, 0.5% as the M8 and M9 metabolites, 0.4% as the M10a metabolite, 0.4% as the M10b metabolite, 0.3% as the M3 metabolite, 0.3% as the M4 and M5 metabolite, 0.2% as the M2 metabolite, and 0.1% as the M1 metabolite. In the feces, 9.0% of the dose was recovered as unchanged drug, 1.0% as the M4 and M5 metabolite, and 0.1% as the M1 metabolite.

Half Life

The average half life of levocetirizine is 7.05±1.54 hours.

Clearance

The average clearance of levocetirizine is 0.57±0.18mL/min/kg.

Toxicity

Patients experiencing an overdose may present with drowsiness. Children may become agitated and restless before drowsiness. Patients should be treated with supportive measures. Dialysis will not assist in removing the drug from the body.

The maximal nonlethal dose in mice and rats is 240mg/kg.

Food Interactions

  • Avoid alcohol.
  • Take with or without food.

Dosage

Adult and children 12 years of age and older: The recommended dose is 5 mg once daily.

Children 6 to 11 years of age: The recommended dose is 2.5 mg (½ tablet or 1 teaspoon oral solution) once daily.

Children 6 months to 5 years of age: The recommended dose is 1.25 mg (½ teaspoon oral solution) once daily.

Pediatric use: The recommended dose for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months to 17 years of age is based on extrapolation of efficacy from adults 18 years of age and older.

Geriatric use: In clinical studies, each approved indication did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently than younger patients.

Hepatic impairment: No dosage adjustment is required in patients with solely hepatic impairment.

Renal impairment:
  • Mild renal impairment (creatinine clearance: 50-80 ml/min): a dose of 2.5 mg once daily is recommended.
  • Moderate renal impairment (creatinine clearance: 30-50 ml/min): a dose of 2.5 mg once every other day is recommended.
  • Severe renal impairment (creatinine clearance: 10-30 ml/min): a dose of 2.5 mg twice weekly (administered once every 3-4 days) is recommended.
  • End-stage renal disease patients (creatinine clearance: <10 ml/min) and patients undergoing hemodialysis: should not receive Levocetirizine.

Frequently Asked Questions About Netis Oral Solution 2.5 mg/5 ml

1. What is Netis Oral Solution 2.5 mg/5 ml?

Netis Oral Solution 2.5 mg/5 ml is a second-generation antihistamine that is used to relieve allergy symptoms such as sneezing, runny nose, and itchy or watery eyes. It is also used to treat symptoms of chronic urticaria (hives) in adults and children.

2. How does Netis Oral Solution 2.5 mg/5 ml work?

Netis Oral Solution 2.5 mg/5 ml works by blocking histamine receptors in the body. Histamine is a substance that causes allergy symptoms such as itching, swelling, and redness. By blocking these receptors, Levocetirizine helps reduce these symptoms.

3. What conditions is Netis Oral Solution 2.5 mg/5 ml used to treat?

Netis Oral Solution 2.5 mg/5 ml is commonly used to treat seasonal allergic rhinitis (hay fever), perennial allergic rhinitis, and chronic urticaria (hives). It can also help reduce itching and swelling caused by allergic reactions.

4. How should I take Netis Oral Solution 2.5 mg/5 ml?

Netis Oral Solution 2.5 mg/5 ml should be taken orally, typically once daily. It can be taken with or without food. Swallow the tablet whole, and if you are using the liquid form, measure it with a dose-measuring spoon or cup.

5. What is the recommended dosage for Netis Oral Solution 2.5 mg/5 ml?

The typical adult dosage is 5 mg once daily, preferably taken in the evening. For children aged 6-11 years, the dose is typically 2.5 mg once daily. Your doctor may adjust the dosage depending on your condition and response to treatment.

6. Can Netis Oral Solution 2.5 mg/5 ml be taken with food?

Yes, Netis Oral Solution 2.5 mg/5 ml can be taken with or without food. Food does not significantly affect the absorption of the drug.

7. What should I do if I miss a dose of Netis Oral Solution 2.5 mg/5 ml?

If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and take your next dose at the regular time. Do not take two doses to make up for the missed one.

8. How long does it take for Netis Oral Solution 2.5 mg/5 ml to start working?

Netis Oral Solution 2.5 mg/5 ml typically starts working within 1 hour of taking the medication, with peak effects occurring within 3-4 hours.

9. What are the common side effects of Netis Oral Solution 2.5 mg/5 ml?

Common side effects include:

  • Dry mouth
  • Drowsiness or fatigue
  • Headache
  • Stomach pain or discomfort
  • Dizziness

10. What are the serious side effects of Netis Oral Solution 2.5 mg/5 ml?

Serious side effects may include:

  • Severe allergic reactions (rash, itching, difficulty breathing)
  • Fast or irregular heartbeat
  • Severe dizziness or fainting

11. Can Netis Oral Solution 2.5 mg/5 ml cause drowsiness?

Although Netis Oral Solution 2.5 mg/5 ml is a second-generation antihistamine, it can still cause mild drowsiness or fatigue in some people. It is generally less sedating than first-generation antihistamines.

12. Can Netis Oral Solution 2.5 mg/5 ml be taken with alcohol?

It is recommended to avoid alcohol while taking Netis Oral Solution 2.5 mg/5 ml, as alcohol may increase drowsiness and impair your ability to concentrate or perform tasks.

13. Can Netis Oral Solution 2.5 mg/5 ml be used in children?

Netis Oral Solution 2.5 mg/5 ml is commonly used for children aged 6 years and older. For younger children, consult a pediatrician before use to determine appropriate dosage and safety.

14. Can Netis Oral Solution 2.5 mg/5 ml be used during pregnancy?

Netis Oral Solution 2.5 mg/5 ml should be used during pregnancy only if clearly needed. Always consult your healthcare provider before using this medication if you are pregnant.

15. Can I take Netis Oral Solution 2.5 mg/5 ml while breastfeeding?

Netis Oral Solution 2.5 mg/5 ml is excreted in breast milk, but it is generally considered safe to use while breastfeeding. However, consult your doctor for personalized advice.

16. How should Netis Oral Solution 2.5 mg/5 ml be stored?

Store Netis Oral Solution 2.5 mg/5 ml at room temperature, away from moisture and heat. Keep it in a tightly sealed container and out of reach of children.

17. What happens if I overdose on Netis Oral Solution 2.5 mg/5 ml?

Overdose symptoms may include drowsiness, dry mouth, and an increased heart rate. Seek immediate medical attention if an overdose is suspected.

18. Can Netis Oral Solution 2.5 mg/5 ml cause weight gain?

Weight gain is not a common side effect of Netis Oral Solution 2.5 mg/5 ml. However, if you experience unusual weight changes, consult your doctor.

19. Can Netis Oral Solution 2.5 mg/5 ml be used for a stuffy nose?

Netis Oral Solution 2.5 mg/5 ml can help with symptoms of nasal congestion associated with allergies but is not specifically designed to treat a stuffy nose. A nasal decongestant may be more effective for this purpose.

20. Can Netis Oral Solution 2.5 mg/5 ml be used long-term?

Yes, Netis Oral Solution 2.5 mg/5 ml can be taken long-term for chronic conditions like allergic rhinitis or chronic urticaria, but it’s important to consult your doctor regularly to monitor its effectiveness and side effects.

21. Can Netis Oral Solution 2.5 mg/5 ml cause dry mouth?

Dry mouth is a common side effect of Netis Oral Solution 2.5 mg/5 ml. Drinking water or using sugar-free gum may help alleviate this symptom.

22. Does Netis Oral Solution 2.5 mg/5 ml cause dizziness?

Dizziness or lightheadedness can occur, especially when standing up quickly. If you feel dizzy, rise slowly to avoid feeling faint.

23. Can Netis Oral Solution 2.5 mg/5 ml cause a rash?

Although rare, Netis Oral Solution 2.5 mg/5 ml can cause a rash or other signs of an allergic reaction. If you experience a rash, swelling, or difficulty breathing, seek immediate medical attention.

24. Can Netis Oral Solution 2.5 mg/5 ml interact with other medications?

Yes, Netis Oral Solution 2.5 mg/5 ml may interact with certain medications, especially other sedatives, alcohol, or other antihistamines. Always inform your doctor about any medications you are taking.

25. Is Netis Oral Solution 2.5 mg/5 ml safe for elderly patients?

Caution should be exercised when giving Netis Oral Solution 2.5 mg/5 ml to elderly patients as they may be more sensitive to the drug’s effects, particularly drowsiness and dizziness. Your doctor may adjust the dosage.

26. Can Netis Oral Solution 2.5 mg/5 ml be used with a decongestant?

Netis Oral Solution 2.5 mg/5 ml can often be safely combined with a decongestant, but it’s important to follow your doctor’s instructions to avoid potential drug interactions.

27. Can Netis Oral Solution 2.5 mg/5 ml cause headaches?

Headaches are a possible side effect of Netis Oral Solution 2.5 mg/5 ml. If headaches become frequent or severe, inform your healthcare provider.

28. Is Netis Oral Solution 2.5 mg/5 ml addictive?

No, Netis Oral Solution 2.5 mg/5 ml is not addictive and does not cause dependence. It is considered safe when used as directed.

29. Can Netis Oral Solution 2.5 mg/5 ml cause nausea?

Some people may experience nausea as a side effect, though it is uncommon. If nausea is persistent, consult your doctor.

30. Can Netis Oral Solution 2.5 mg/5 ml be taken with food?

Yes, Netis Oral Solution 2.5 mg/5 ml can be taken with or without food. Food does not significantly affect how the medication is absorbed.

31. How long does the effect of Netis Oral Solution 2.5 mg/5 ml last?

The effects of Netis Oral Solution 2.5 mg/5 ml usually last for 24 hours, which is why it is typically taken once daily.

32. Can Netis Oral Solution 2.5 mg/5 ml treat allergic conjunctivitis?

Yes, Netis Oral Solution 2.5 mg/5 ml can help alleviate symptoms of allergic conjunctivitis, such as itching and watery eyes.

33. Can Netis Oral Solution 2.5 mg/5 ml be used for sinusitis?

Netis Oral Solution 2.5 mg/5 ml is not typically used to treat sinus infections, but it may help relieve symptoms such as nasal congestion and sneezing associated with allergies.

34. Can Netis Oral Solution 2.5 mg/5 ml treat pet allergies?

Yes, Netis Oral Solution 2.5 mg/5 ml can help treat symptoms of pet allergies, including sneezing, itchy eyes, and nasal congestion.

35. Can Netis Oral Solution 2.5 mg/5 ml help with food allergies?

Netis Oral Solution 2.5 mg/5 ml can help relieve symptoms of food allergies, such as itching, hives, and swelling, but it is not a substitute for epinephrine in severe reactions like anaphylaxis.

36. Can Netis Oral Solution 2.5 mg/5 ml be used to treat insect bites?

Netis Oral Solution 2.5 mg/5 ml can help reduce itching and swelling caused by insect bites, but it is not a primary treatment for these conditions.

37. Can Netis Oral Solution 2.5 mg/5 ml be used for hay fever?

Yes, Netis Oral Solution 2.5 mg/5 ml is commonly used to treat hay fever (seasonal allergic rhinitis), helping alleviate symptoms like sneezing and a runny nose.

38. Is Netis Oral Solution 2.5 mg/5 ml safe for pregnant women?

Netis Oral Solution 2.5 mg/5 ml should be used during pregnancy only if absolutely necessary. Consult your doctor to discuss the risks and benefits.

39. Can Netis Oral Solution 2.5 mg/5 ml cause constipation?

Constipation is not a common side effect of Netis Oral Solution 2.5 mg/5 ml, but if you experience it, inform your healthcare provider.

40. Can Netis Oral Solution 2.5 mg/5 ml be used for mold allergies?

Netis Oral Solution 2.5 mg/5 ml is effective in treating symptoms of mold allergies, such as sneezing, nasal congestion, and watery eyes.

41. Can Netis Oral Solution 2.5 mg/5 ml be taken with other allergy medications?

Netis Oral Solution 2.5 mg/5 ml can often be safely taken with other allergy treatments, but you should check with your doctor to avoid drug interactions.

42. How does Netis Oral Solution 2.5 mg/5 ml differ from other antihistamines?

Netis Oral Solution 2.5 mg/5 ml is a second-generation antihistamine, which means it is less likely to cause sedation or drowsiness compared to first-generation antihistamines like diphenhydramine.

43. Can Netis Oral Solution 2.5 mg/5 ml be used for cold symptoms?

Netis Oral Solution 2.5 mg/5 ml is not intended for treating cold symptoms but may help alleviate some symptoms, such as nasal congestion, if caused by allergies.

44. Is Netis Oral Solution 2.5 mg/5 ml a prescription medication?

In some countries, Netis Oral Solution 2.5 mg/5 ml is available over the counter, while in others, it may require a prescription from your healthcare provider.

45. Can Netis Oral Solution 2.5 mg/5 ml treat allergic rhinitis?

Yes, Netis Oral Solution 2.5 mg/5 ml is commonly used to treat allergic rhinitis, helping alleviate symptoms such as sneezing, runny nose, and itchy eyes.

46. Does Netis Oral Solution 2.5 mg/5 ml interact with food?

Netis Oral Solution 2.5 mg/5 ml is not significantly affected by food. You can take it with or without food.

47. Can Netis Oral Solution 2.5 mg/5 ml cause memory problems?

Memory problems are rare, but some people may experience mild cognitive effects. If you notice any changes in memory or concentration, consult your doctor.

48. Can Netis Oral Solution 2.5 mg/5 ml help with pet dander allergies?

Yes, Netis Oral Solution 2.5 mg/5 ml is effective for treating symptoms caused by pet dander allergies, such as sneezing and watery eyes.

49. Can Netis Oral Solution 2.5 mg/5 ml be used for skin allergies?

Netis Oral Solution 2.5 mg/5 ml may help relieve itching and rash associated with allergic reactions, including skin allergies.

50. Can Netis Oral Solution 2.5 mg/5 ml be used to treat food allergies?

Netis Oral Solution 2.5 mg/5 ml can help alleviate mild symptoms of food allergies, such as hives and itching, but it is not a treatment for severe reactions like anaphylaxis.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

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