Mycophenolic Acid
Mycophenolic acid is an active metabolite of the immunosuppressant mycophenolate mofetil, used to treat autoimmune diseases such as lupus and rheumatoid arthritis.
Uses For
Mycophenolic acid is approved to:
- Treat transplant rejection in adults and in children ages 2 years and older.
- Prevent the recurrence of kidney allograft rejection in adults.
| Brand Name | Mycophenolic acid |
|---|---|
| Type | |
| Weight | |
| Generic | Mycophenolic acid |
| Manufacturer | |
| Available in | English বাংলা |
Mechanism of Action
Mycophenolic acid works by blocking an enzyme that is necessary for the body’s defense reaction to foreign substances. By blocking this enzyme, mycophenolic acid reduces the body’s ability to reject an organ transplant.
How Long Does it Take to Work
Mycophenolic acid can take several weeks to produce therapeutic benefits. However, if combined with other immunosuppressants, the onset of action of mycophenolic acid may be reduced.
Absorption
Mycophenolic acid is rapidly and completely absorbed after an oral dose. It is also well-absorbed following an intramuscular (IM) injection. The peak plasma concentrations of mycophenolic acid occur about two hours after ingestion.
Route of Elimination
Mycophenolic acid is readily eliminated by the kidney and has a half-life of about one hour.
Dosage
Dosage in adult kidney transplant patients: The recommended dose of Mycophenolic acid is 720 mg administered twice daily (1440 mg total daily dose).Dosage in pediatric kidney transplant patients: The recommended dose of Mycophenolic acid in conversion (at least 6 months post-transplant) pediatric patients age 5 years and older is 400 mg/m2 body surface area (BSA) administered twice daily (up to a maximum dose of 720 mg administered twice daily). Pediatric patients with a BSA of 1.19 to 1.58 m2 may be dosed either with three Mycophenolic acid 180 mg tablets, or one 180 mg tablet plus one 360 mg tablet twice daily (1080 mg daily dose). Patients with a BSA of >1.58 m2 may be dosed either with four Mycophenolic acid 180 mg tablets, or two Mycophenolic acid 360 mg tablets twice daily (1440 mg daily dose).
Mycophenolic acid tablets should be taken on an empty stomach, 1 hour before or 2 hours after food intake. Tablets should not be crushed, chewed, or cut prior to ingesting. The tablets should be swallowed whole in order to maintain the integrity of the enteric coating.
Mycophenolic acid is typically administered in an oral form or by intramuscular injection. The usual dose is two to three times daily, depending on the patient’s condition. The precise dosage and duration of treatment should be determined by a health care professional.
Administration
Mycophenolic acid is usually taken orally with food, or as an intramuscular injection. It is important to take mycophenolic acid at the same time each day to ensure consistent therapeutic effects.
Side-Effect
Mycophenolic acid can cause side effects including nausea, vomiting, abdominal pain, diarrhea, headache, dizziness, and fatigue.
Toxicity
Mycophenolic acid can build up in the bloodstream over time if too much is taken. This can lead to serious side effects and can even be fatal in some cases.
Precaution
It is important to closely follow the dosing instructions from your healthcare practitioner. Patients taking mycophenolic acid should also be aware of any potential drug-drug interactions, as mycophenolic acid may interact with other medications. It is also important to be aware of any potential food and drink interactions.
Interaction
Mycophenolic acid can interact with many other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), statins, cyclosporine, tacrolimus, and herbal medicines. Mycophenolic acid can also interact with some vitamins, minerals, and amino acids. Any medical treatments or surgeries being used should be discussed with your healthcare provider before taking mycophenolic acid.
Disease Interaction
Patients with certain diseases or conditions may be at increased risk for developing side effects or other complications. Therefore, it is important to discuss your medical history with your healthcare provider before taking mycophenolic acid.
Drug Interaction
Mycophenolic acid can interact with other medications. It is important to tell your healthcare provider about any drugs, over-the-counter products, or herbal supplements you are taking.
Food Interactions
Mycophenolic acid can interact with certain foods, such as milk, eggs, and soybeans. It is important to follow the dietary instructions provided by your healthcare provider.
Pregnancy Use
Mycophenolic acid is not recommended for use in pregnant women, as it can cause fetal harm. If you are pregnant and take mycophenolic acid, it is important to tracking your pregnancy with regular ultrasounds.
LactationUse
Mycophenolic acid is not recommended for use in breastfeeding women. It is important to do thorough research and consult with a healthcare professional prior to taking mycophenolic acid while breastfeeding.
Acute Overdose
If mycophenolic acid is taken in large doses, it can lead to serious health consequences such as vomiting, abdominal pain, fatigue, nausea, rash, and dizziness. If an overdose is suspected, medical attention should be sought immediately.
Contraindication
Mycophenolic acid is contraindicated in patients with a prior or current hypersensitivity reaction to the drug. It is also not recommended for use in patients with severe renal or hepatic impairment or in patients who are pregnant.
Use Direction
Mycophenolic acid should be taken exactly as prescribed by a healthcare provider. The dosage and schedule of doses can vary depending on the condition being treated. Swallow the tablet whole and do not crush or chew. If an injection is prescribed, it should be administered intramuscularly. Mycophenolic acid should always be taken with food.
Storage Condition
Mycophenolic acid should be stored at room temperature and should be kept out of reach of children.
Volume Of Distribution
The volume of distribution of mycophenolic acid is 0.33 L/kg.
Half Life
The elimination half-life of mycophenolic acid is 1.0–2.0 hours.
Clearance
Mycophenolic acid is cleared from the body by the kidneys. Renal clearance is approximately 0.6 L/hr.
See in details version Mycophenolic acid also Mycophenolic acid in bangla
