Movex Tablet 100 mg 100 mg Uses, Dosage, Side Effects & Price - মোভেক্স ট্যাবলেট

Name: Movex Tablet 100 mg
Brand: Movex
SKU: movex-tablet-100-mg
Price: 5 BDT
Availability: OnlineOnly

Brand Name	Movex
Type	Tablet
Weight	100 mg
Generic	Aceclofenac
Manufacturer	Opsonin Pharma Ltd.
Price	Unit: ৳ 5.00 (10 x 10: ৳ 500.00) Strip: ৳ 50.00

Brand Name

Movex

Type

Tablet

Weight

100 mg

Generic

Aceclofenac

Manufacturer

Opsonin Pharma Ltd.

Price

Unit: ৳ 5.00 (10 x 10: ৳ 500.00) Strip: ৳ 50.00

About Movex

Movex Tablet (Opsonin Pharma Ltd.) is a brand medicine containing the generic Aceclofenac . Current listed price in Bangladesh: Unit: ৳ 5.00 (10 x 10: ৳ 500.00) Strip: ৳ 50.00.

Introduction

Movex Tablet 100 mg is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies . Movex Tablet 100 mg potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. Movex Tablet 100 mg belongs to BCS Class II as it possesses poor aqueous solubility . It displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation . Movex Tablet 100 mg is also reported to be effective in other painful conditions such as dental and gynaecological conditions . In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, Diclofenac, via chemical modification in effort to improve the gastrointestinal tolerability of the drug. It is a more commonly prescribed drug in Europe.

Uses

Movex Tablet 100 mg is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Associated Conditions

Ankylosing Spondylitis (AS)
Osteoarthritis (OA)
Rheumatoid Arthritis

Pharmacodynamics

Movex Tablet 100 mg is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of inflammatory mediators in response to inflammatory stimuli. Movex Tablet 100 mg displays more selectivity towards COX-2 (IC50 of 0.77uM) than COX-1 (IC50 of >100uM), which promotes its gastric tolerance compared to other NSAIDs. The primary metabolite, 4'-hydroxyaceclofenac, also minimally inhibits COX-2 with IC50 value of 36uM . Although the mode of action of aceclofenac is thought to mainly arise from the inhibition of synthesis of prostaglandins (PGE2), aceclofenac also inhibits the production of inflammatory cytokines, interleukins (IL-1β, IL-6), and tumor necrosis factors (TNF) . It is also reported that aceclofenac also affects the cell adhesion molecules from neutrophils [A19763]. Movex Tablet 100 mg also targets the synthesis of glycosaminoglycan and mediates chrondroprotective effects .

Mechanism of Action

Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway. Inhibition of IL-6 is thought to be mediated by diclofenac converted from aceclofenac . Suppressed action of inflammatory cytokines decreases the production of reactive oxygen species. Movex Tablet 100 mg is shown to decreased production of nitrous oxide in human articular chondrocytes . In addition, aceclofenac interferes with neutrophil adhesion to endothelium by decreasing the expression of L-selectin (CD62L), which is a cell adhesion molecule expressed on lymphocytes . Movex Tablet 100 mg is proposed to stimulate the synthesis of glycosaminoglycan in human osteoarthritic cartilage which may be mediated through its inhibitory action on IL-1 production and activity . The chrondroprotective effects are generated by 4'-hydroxyaceclofenac which suppresses IL-1 mediated production of promatrix metalloproteinase-1 and metalloproteinase-3 and interferes with the release of proteoglycan from chrondrocytes .

Absorption

Movex Tablet 100 mg is rapidly and completely absorbed from the gastrointestinal tract and circulates mainly as unchanged drug following oral administration. Peak plasma concentrations are reached around 1.25 to 3 hours post-ingestion, and the drug penetrates into the synovial fluid where the concentration may reach up to 60% of that in the plasma . There is no accumulation in regular dosing, with similar maximum plasma concentration (Cmax) and time to reach peak plasma concentration (Tmax) after single and multiple doses .

Volume of Distribution

The volume of distribution is approximately 25 L .

Protein Binding

It is reported to be highly protein-bound (>99%) .

Route of Elimination

The main route of elimination is via the urine where the elimination accounts for 70-80% of clearance of the drug . Approximately two thirds of the administered dose is excreted via the urine, mainly as glucuronidated and hydroxylated forms of aceclofenac . About 20% of the dose is excreted into feces .

Half Life

The mean plasma elimination half-life is approximately 4 hours .

Clearance

The mean clearance rate is approximately 5 L/h .

Toxicity

Some common adverse effects include gastro-intestinal disorders (dyspepsia, abdominal pain, nausea), rash, ruber, urticaria, symptoms of enuresis, headache, dizziness, and drowsiness . Oral LD50 value in rats is 130 mg/kg .

Food Interactions

Take with or without food.

Dosage

Extended release tablet: The recommended dose in adults is one 200 mg Movex Tablet 100 mg tablet daily or as prescribed by the physician.
Film coated tablet: The recommended dose in adults is 100 mg, twice daily.

Frequently Asked Questions About Movex Tablet 100 mg

1. What is Movex Tablet 100 mg?

Movex Tablet 100 mg is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain in conditions such as arthritis, muscle pain, and other musculoskeletal disorders.

2. How does Movex Tablet 100 mg work?

Movex Tablet 100 mg works by inhibiting the production of prostaglandins, chemicals in the body that promote inflammation, pain, and fever. By reducing prostaglandin levels, it helps to reduce pain and inflammation.

3. What conditions is Movex Tablet 100 mg used to treat?

Movex Tablet 100 mg is commonly used to treat:

Osteoarthritis
Rheumatoid arthritis
Muscle pain
Back pain
Joint pain
Postoperative pain
Gout attacks

4. How should Movex Tablet 100 mg be taken?

Movex Tablet 100 mg is typically taken orally in the form of tablets. It should be taken with food to reduce the risk of stomach irritation. Follow the dosage instructions provided by your healthcare provider.

5. What is the usual dosage of Movex Tablet 100 mg?

The typical dose for adults is one 100 mg tablet twice a day. However, the dosage may vary depending on the condition being treated and individual factors.

6. Can Movex Tablet 100 mg be taken with other medications?

Movex Tablet 100 mg may interact with other medications, especially blood thinners, corticosteroids, and certain blood pressure medications. Always consult a healthcare provider before combining it with other drugs.

7. Can Movex Tablet 100 mg be used during pregnancy?

Movex Tablet 100 mg is generally not recommended during pregnancy, particularly in the third trimester, as it may affect fetal development and cause complications. Always consult a doctor before using it during pregnancy.

8. Is Movex Tablet 100 mg safe for breastfeeding mothers?

Movex Tablet 100 mg should be avoided while breastfeeding as it can pass into breast milk and may harm the infant. Consult your doctor before using it while breastfeeding.

9. What are the common side effects of Movex Tablet 100 mg?

Common side effects include:

Stomach upset
Headache
Dizziness
Nausea
Diarrhea

10. Can Movex Tablet 100 mg cause gastrointestinal problems?

Yes, like other NSAIDs, Movex Tablet 100 mg can cause gastrointestinal issues such as ulcers, bleeding, or irritation in the stomach. It should be taken with food to minimize these risks.

11. Can I take Movex Tablet 100 mg for a headache?

Movex Tablet 100 mg can help relieve pain, including headaches, particularly those associated with inflammation. However, it is not specifically indicated for headache relief.

12. How long does Movex Tablet 100 mg take to work?

Movex Tablet 100 mg typically starts to work within 30 minutes to 1 hour after taking it, with maximum effect seen in 1 to 2 hours.

13. Can Movex Tablet 100 mg cause liver damage?

While rare, Movex Tablet 100 mg can cause liver problems, including jaundice or elevated liver enzymes. Regular monitoring of liver function may be advised for long-term use.

14. Can Movex Tablet 100 mg cause kidney problems?

Yes, long-term use of Movex Tablet 100 mg can affect kidney function. It is essential to use this medication under medical supervision, especially if you have pre-existing kidney conditions.

15. Can Movex Tablet 100 mg be used for back pain?

Yes, Movex Tablet 100 mg is effective for treating back pain due to its anti-inflammatory properties. It can reduce inflammation and pain in conditions such as muscle strains or arthritis.

16. Can Movex Tablet 100 mg be used for arthritis?

Yes, Movex Tablet 100 mg is commonly prescribed for both osteoarthritis and rheumatoid arthritis to relieve pain, swelling, and stiffness in the joints.

17. How should I store Movex Tablet 100 mg?

Store Movex Tablet 100 mg in a cool, dry place, away from direct sunlight, and keep it out of reach of children. Follow the storage instructions provided on the packaging.

18. What should I do if I miss a dose of Movex Tablet 100 mg?

If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Never take two doses at once.

19. Can I take Movex Tablet 100 mg with alcohol?

It is not recommended to consume alcohol while taking Movex Tablet 100 mg, as it may increase the risk of gastrointestinal bleeding and liver damage.

20. Can Movex Tablet 100 mg cause dizziness?

Yes, dizziness is a potential side effect of Movex Tablet 100 mg. If you experience dizziness, avoid driving or operating heavy machinery.

21. Is Movex Tablet 100 mg safe for elderly people?

Elderly individuals may be more sensitive to the side effects of Movex Tablet 100 mg, such as gastrointestinal or kidney problems. Dose adjustments and monitoring may be necessary.

22. Can Movex Tablet 100 mg be used for muscle pain?

Yes, Movex Tablet 100 mg can be used to relieve muscle pain, particularly pain caused by inflammation, sprains, or strains.

23. Can Movex Tablet 100 mg interact with other NSAIDs?

Taking Movex Tablet 100 mg with other NSAIDs can increase the risk of side effects such as gastrointestinal bleeding or ulcers. It is recommended to avoid combining it with other NSAIDs.

24. How long can I take Movex Tablet 100 mg?

Movex Tablet 100 mg should be used for the shortest time necessary to treat the symptoms. Long-term use requires medical supervision to monitor for potential side effects.

25. Can I take Movex Tablet 100 mg for gout pain?

Yes, Movex Tablet 100 mg can be used to treat the pain and inflammation associated with acute gout attacks.

26. Can Movex Tablet 100 mg cause weight gain?

Weight gain is not a common side effect of Movex Tablet 100 mg. However, some individuals may experience fluid retention, which can cause temporary weight gain.

27. What should I do if I experience an allergic reaction to Movex Tablet 100 mg?

If you experience symptoms of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek medical attention immediately.

28. Is Movex Tablet 100 mg effective for post-surgical pain?

Yes, Movex Tablet 100 mg can be used to manage pain after surgery, particularly to reduce inflammation and discomfort.

29. Can I take Movex Tablet 100 mg on an empty stomach?

It is recommended to take Movex Tablet 100 mg with food to reduce the risk of stomach irritation and gastrointestinal side effects.

30. Can Movex Tablet 100 mg be used for toothache pain?

Movex Tablet 100 mg can be used for toothache pain, particularly when inflammation is a contributing factor. However, it is not specifically indicated for dental pain.

31. Can I take Movex Tablet 100 mg with paracetamol?

In some cases, Movex Tablet 100 mg and Paracetamol may be taken together for enhanced pain relief, but it's important to consult a healthcare provider before combining them to avoid potential interactions.

32. Is Movex Tablet 100 mg available over the counter?

Movex Tablet 100 mg is typically available by prescription only, as it is a strong anti-inflammatory drug with potential side effects that require medical supervision.

33. Can Movex Tablet 100 mg cause heart problems?

Long-term use of Movex Tablet 100 mg, like other NSAIDs, may increase the risk of heart attack or stroke. People with existing heart conditions should consult a doctor before using Movex Tablet 100 mg.

34. Can I use Movex Tablet 100 mg for a cold?

Movex Tablet 100 mg is not specifically indicated for the common cold, but it can be used to relieve the pain and inflammation associated with cold-related symptoms such as sore throat or muscle aches.

35. How does Movex Tablet 100 mg compare to other NSAIDs?

Movex Tablet 100 mg is considered to be more selective for COX-2 (the enzyme responsible for inflammation) than some other NSAIDs, potentially leading to fewer gastrointestinal side effects.

36. Can Movex Tablet 100 mg cause rashes?

Yes, skin rashes are a possible side effect of Movex Tablet 100 mg. If you develop a rash, stop using the drug and contact your healthcare provider.

37. Can I stop taking Movex Tablet 100 mg abruptly?

It is not recommended to stop taking Movex Tablet 100 mg abruptly without consulting your doctor, especially if you have been using it for a long time. Gradual dose reduction may be necessary.

38. Does Movex Tablet 100 mg affect blood pressure?

Movex Tablet 100 mg can affect blood pressure, particularly in those with pre-existing hypertension. It is important to monitor blood pressure during treatment.

39. Can Movex Tablet 100 mg cause dry mouth?

Dry mouth is not a common side effect of Movex Tablet 100 mg. However, if it occurs, drinking water or using saliva substitutes may help.

40. Can I take Movex Tablet 100 mg for menstrual pain?

Movex Tablet 100 mg can help relieve pain associated with menstruation, particularly if inflammation is contributing to the discomfort.

41. Is Movex Tablet 100 mg safe for children?

Movex Tablet 100 mg is generally not recommended for children under 18 years of age unless specifically prescribed by a doctor.

42. Can Movex Tablet 100 mg cause blurred vision?

Blurred vision is not a common side effect of Movex Tablet 100 mg. However, if you experience this, you should seek medical advice.

43. How can I minimize the risk of gastrointestinal side effects from Movex Tablet 100 mg?

Taking Movex Tablet 100 mg with food, using the lowest effective dose for the shortest time, and avoiding alcohol can help reduce gastrointestinal side effects.

44. Can Movex Tablet 100 mg be used for tendonitis?

Yes, Movex Tablet 100 mg can be used to relieve pain and inflammation associated with tendonitis.

45. Does Movex Tablet 100 mg affect the immune system?

Movex Tablet 100 mg may suppress the immune system slightly, which can make it harder for the body to fight infections. Consult your doctor if you are at risk for infections.

46. How quickly does Movex Tablet 100 mg reduce inflammation?

Movex Tablet 100 mg typically reduces inflammation within a few hours of taking it, with the peak effect occurring after 1-2 hours.

47. Can Movex Tablet 100 mg cause drowsiness?

While drowsiness is not a common side effect of Movex Tablet 100 mg, some people may feel fatigued. If this happens, avoid driving or operating machinery.

48. Can I take Movex Tablet 100 mg if I have a history of ulcers?

People with a history of ulcers should use Movex Tablet 100 mg with caution, as NSAIDs can exacerbate gastrointestinal issues. Consult your healthcare provider for advice.

49. Can Movex Tablet 100 mg be used for fibromyalgia?

Movex Tablet 100 mg can be used to manage the pain and inflammation associated with fibromyalgia, but it is typically used as part of a broader treatment plan.