Milam Tablet

Milam Tablet 7.5 mg Introduction

Milam Tablet 7.5 mg is a benzodiazepine medication used to induce and maintain anaesthesia, aid in sedation for surgery or other medicinal procedures, and treat certain types of seizures, anxiety disorders, and insomnia. It is typically administered in intravenous, intramuscular, and oral form, and can cause drowsiness, confusion, and muscle relaxation depending on the dose.

Uses of Milam Tablet 7.5 mg

Inducing and Maintaining Anaesthesia
Sedation during surgery or other medical procedures
Treatment of certain types of seizure disorders
Treatment of anxiety disorders
Treatment of insomnia

Brand Name	Milam
Type	Tablet
Weight	7.5 mg
Generic	Midazolam
Manufacturer	Eskayef Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Milam Tablet 7.5 mg is a central nervous system (CNS) depressant that works primarily by activating the gamma-aminobutyric acid (GABA) receptor-chloride channel receptor complex. This interaction leads to increased chloride ion conductance, membrane hyperpolarization, and ultimately, the suppression of excitatory signaling. Additionally, it binds to benzodiazepine receptors which causes sedative, anxiolytic, and anticonvulsant activity.

How Long Does it Take to Work?

The effects of midazolam can occur within minutes as it is rapidly and readily absorbed. Intestinal absorption is higher when it is injected intravenously compared to the intramuscular route.

Absorption

Milam Tablet 7.5 mg is rapidly and readily absorbed when administered orally, intravenously, or intramuscularly. Intestinal absorption is higher when it is injected intravenously compared to the intramuscular route.

Route of Elimination

Milam Tablet 7.5 mg is rapidly metabolized in the liver by cytochrome P450 enzymes and subsequently excreted by the kidneys in the form of metabolites.

Dosage

Oral dosage:

For adults: 7.5-15 mg daily.
In elderly and debilitated patients: The recommended dose is 7.5 mg.
In premedication: 15 mg of Midazolam should be given 30-60 minutes before the procedure.

Intravenous administration:

Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg.
Induction of Anesthesia: The dose is 10-15 mg.

Intramuscular administration:

Adult: 0.07-0.1 mg/kg body weight. The usual dose is about 5 mg.
Children: 0.15-0.20 mg/kg
Elderly and debilitated patients: 0.025-0.05 mg/kg

Rectal administration in children:

For preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min. before induction of general anesthesia.

The dosage of midazolam is variable and depends on the patient's age, size, indication, route, and desired effects. When administered orally, typical adult dosages range from 0.5 mg to 6 mg taken two to three times daily. Intramuscular and Intravenous dosing typically ranges from 0.25 mg to 5 mg depending on the desired effect.

Administration

Milam Tablet 7.5 mg can be administered orally, intramuscularly, and intravenously. Oral administration can be done with or without food. Intramuscular injection should be done in a deep muscle site with sterile technique.

Side Effects

Dizziness
Lightheadedness
Headache
Sleepiness
Nausea
Blurred vision
Restlessness
Confusion
Muscle weakness
Drowsiness

Toxicity

Overdose of midazolam can be lethal as it can cause respiratory depression, hypotension, coma, and death. The risk of toxicity increases in cases of existing liver or kidney impairment, polymedication, and when other drugs are taken in conjunction with midazolam.

Precaution

Milam Tablet 7.5 mg should not be taken with alcohol, other benzodiazepines, opioids, or other CNS depressants.
Milam Tablet 7.5 mg should not be taken if the individual is pregnant or nursing.
Milam Tablet 7.5 mg should not be taken if the individual has a history of depression, suicidal thoughts, or addiction to drugs or alcohol.
Milam Tablet 7.5 mg should not be taken if the individual has any allergies, is taking any other medications, or has any medical or mental conditions.
It is important to always consult your doctor before consuming midazolam.
Do not stop suddenly taking midazolam without consulting your doctor.

Interactions

Milam Tablet 7.5 mg and other CNS depressants have an additive effect and should not be taken together.
Incompatible drugs to be avoided include, but are not limited to, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, some antihistamines and alcohol.
Monitoring is recommended when taking midazolam with antiepileptic drugs (AEDs) or other drugs that affect liver enzyme activity.
Some drugs may increase the effects of midazolam, including certain antibiotics, antifungals, antipsychotics, calcium channel blockers, and certain antivirals.

Disease Interactions

Liver or kidney dysfunctions can increase the chances of experiencing adverse effects.
Breathing disorders can lead to the accumulation of midazolam in the body and increase its sedative effects.
Psychiatric disorders, including depression or suicidal thoughts, can increase the risk of addiction and other serious side effects.
Milam Tablet 7.5 mg should be used with caution in individuals with mitochondrial disorders.

Drug Interactions

Milam Tablet 7.5 mg interacts with many other drugs and can cause additive CNS depressant effects. Drugs such as opioids, benzodiazepines, antifungals, antipsychotics, calcium channel blockers, and certain antivirals may increase the sedative effects of midazolam. When combined with antiepileptic drugs (AEDs) or other drugs that affect liver enzyme activity, monitoring is recommended.

Food Interactions

Milam Tablet 7.5 mg does not interact with food, but it may take longer to take effect if taken with food.

Pregnancy Use

Milam Tablet 7.5 mg should not be taken by pregnant women due to the risk of teratogenic effects. Its safety has not been established for lactation. It should be avoided in women who are breastfeeding.

Lactation Use

Milam Tablet 7.5 mg should not be taken by lactating women due to the risk of teratogenic effects. Its safety has not been established for lactation. It should be avoided in women who are breastfeeding.

Acute Overdose

Acute overdose of midazolam increases the risk of coma, respiratory depression, hypotension, and death. Supportive measures and symptomatic treatment should be initiated promptly. Forced diuresis, dialysis, exchange transfusion, and hemodialysis are not expected to be effective in removing the drug from the body.

Contraindication

Milam Tablet 7.5 mg is contraindicated in patients with known allergy or hypersensitivity to benzodiazepines.
It should not be used by pregnant women or women who are breast-feeding.
It should not be taken if the individual has a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Use Directions

Milam Tablet 7.5 mg can be taken with or without food.
Intramuscular injection should be done in a deep muscle site with sterile technique.
Never consume more than the prescribed dosage. Always take midazolam as directed by your doctor, pharmacist, or other health care provider.
Do not suddenly stop taking midazolam without consulting your doctor.