Miganil Tablet

Introduction

Miganil Tablet 10 mg is a calcium channel blocker used in the treatment of migraine, vertigo, and neurosensory deafness. It is a highly selective antagonist of the L-type calcium channels in the brain, modulating the release of excitatory neurotransmitters such as glutamate, norepinephrine, and serotonin, thereby providing relief from the symptoms of migraine.

Uses

Miganil Tablet 10 mg is used to treat migraine, vertigo, and neurosensory deafness. It is also used to prevent migraine headaches and other similar conditions.

Brand Name	Miganil
Type	Tablet
Weight	10 mg
Generic	Flunarizine
Manufacturer	Globe Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Miganil Tablet 10 mg is a highly selective antagonist of the L-type calcium channels in the brain. By blocking the L-type channels, it modulates the release of excitatory neurotransmitters such as glutamate, norepinephrine, and serotonin, thereby providing relief from the symptoms of migraine. Miganil Tablet 10 mg also blocks the calcium channels present in peripheral blood vessels, thereby reduced the amount of calcium available, which leads to the relaxation of the blood vessels and reduction in blood pressure.

How Long Does It Take to Work?

The effects of flunarizine can be noticed after about 6-8 hours after the initial dose. It may take up to two weeks for the full therapeutic effects of flunarizine to be noticed.

Absorption

Miganil Tablet 10 mg is rapidly and completely absorbed after oral administration. The peak plasma concentrations are reached in 1-2 hours.

Route of Elimination

Miganil Tablet 10 mg is eliminated from the body in urine and feces. It undergoes extensive biotransformation and has an elimination half-life of around 25-30 hours.

Dosage

Migraine Prophylaxis:

Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued.
Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses.

Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.

Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).

Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy

Miganil Tablet 10 mg is available in the form of tablets and capsules containing 10mg of flunarizine. The recommended dosage of flunarizine for migraine prophylaxis is 10-20mg per day in divided doses, or as advised by a doctor. It should not be taken more than twice a day.

Administration

Miganil Tablet 10 mg should be taken orally with or without food. It can be taken with food to reduce the adverse effects. It should not be taken with alcohol as it can increase the side-effects.

Side Effects

The side effects associated with flunarizine include drowsiness, abdominal pain, nausea, dizziness, fatigue, blurred vision, dry mouth, headache and constipation.

Toxicity

The acute oral toxicity of flunarizine is very low. Long-term exposure of flunarizine in higher doses than recommended can lead to toxicity. The primary effects of flunarizine toxicity include bradycardia, QT prolongation, and cardiac arrhythmias.

Precaution

It is recommended to avoid using flunarizine in patients with history of congenital or acquired QT prolongation, orthostatic intolerance, myasthenia gravis, depression, Parkinson’s disease and renal impairment.