Introduction
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Uses
Merozolyn Tablet 5 mg is a thiazide-like diuretic used to treat hypertension.
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Associated Conditions
Pharmacodynamics
Merozolyn Tablet 5 mg is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies.
Mechanism of Action
The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Merozolyn Tablet 5 mg acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Merozolyn Tablet 5 mg does not inhibit carbonic anhydrase. The antihypertensive mechanism of action of metolazone is not fully understood but is presumed to be related to its saluretic and diuretic properties.
Absorption
Peak blood levels are obtained within 2 to 4 hours of oral administration. The rate and extent of absorption are formulation dependent.
Protein Binding
50-70% bound to erythrocytes, up to 33% bound to plasma proteins, 2-5% of the drug in circulation is unbound
Route of Elimination
Most of the drug is excreted in the unconverted form in the urine.
Half Life
Approximately 14 hours.
Toxicity
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Food Interactions
- Take with food. Food reduces irritation.
Dosage
Usual Dosages-
- Edema of cardiac failure: Merozolyn Tablet 5 mg 5-10 mg, once daily
- Edema of renal disease: Merozolyn Tablet 5 mg 5-20 mg, once daily
Hypertension: Mild to moderate essential hypertension: Merozolyn Tablet 5 mg 2.5-5 mg, once daily.
Treatment of Hypertension: The time interval required for the initial dosage regimen of Merozolyn Tablet 5 mg to show effect may vary from three to four days, to three to six weeks, in the treatment of elevated blood pressure. Doses should be adjusted at appropriate intervals to achieve maximum therapeutic effect.
