Meclizine + Pyridoxine

Introduction

Meclizine+Pyridoxine is a prescription medication used to treat symptoms of motion sickness such as nausea, vomiting, dizziness, and headache. It is a combination of meclizine hydrochloride, an antihistamine, and pyridoxine (vitamin B6), which helps to reduce the drowsiness associated with meclizine.

Uses

Meclizine+Pyridoxine is used for the prevention and treatment of symptoms of motion sickness, such as nausea, vomiting, dizziness, and headache. It may also be used to treat symptoms associated with vertigo.

Brand Name	Meclizine + Pyridoxine
Type
Weight
Generic	Meclizine + Pyridoxine
Manufacturer
Available in	English বাংলা

Mechanism of Action

Meclizine hydrochloride works as an antihistamine to block the action of histamine, which is a chemical messenger responsible for vomiting and nausea. Pyridoxine (vitamin B6) helps to reduce the drowsiness associated with meclizine.

How Long Does it Take to Work?

Meclizine+Pyridoxine usually starts working within 30 minutes of taking the medication. For the best results, take the medication 1 hour before travel.

Absorption

Meclizine+Pyridoxine is rapidly absorbed from the gastrointestinal tract with peak plasma concentrations reached in 1 to 2 hours.

Route of Elimination

Meclizine+Pyridoxine is mostly eliminated unchanged in the urine by glomerular filtration and tubular excretion.

Dosage

Adult and Children 12 years of age & over:

• Nausea and vomiting: 25-50 mg daily or as directed by a physician.
• Motion sickness: Take an initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey.
• Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment.
• Vertigo: 25-100 mg daily in divided doses.
• Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.

The safety and efficacy for use in children less than 12 years of age have not been established. The recommended dose of Meclizine+Pyridoxine is 1 tablet every 8-12 hours for adults and children 12 years of age or older, and 1 tablet 3 to 4 times daily for children 6-11 years of age. The maximum recommended daily dose is 6 tablets per day.

Administration

Meclizine+Pyridoxine can be taken with or without food.

Side Effects

Common side effects of Meclizine+Pyridoxine include dry mouth, fatigue, drowsiness, blurred vision, and difficulty focusing. Less common but more serious side effects include severe dizziness, fainting, skin rash, and difficulty breathing.

Toxicity

Meclizine+Pyridoxine is not considered to be toxic at therapeutic doses. In cases of overdose, death is usually due to respiratory depression.

Precautions

Meclizine+Pyridoxine should be used with caution in patients with glaucoma, liver or kidney impairment, asthma, breathing problems, or problems with urination. It may also interact with certain medications, so patients should inform their doctor of any medications they are taking prior to taking Meclizine+Pyridoxine.

Interactions

Meclizine+Pyridoxine may interact with medications such as antihistamines, antidepressants, antipsychotics, and anticonvulsants. Patients should inform their health care provider of any medications they are taking prior to taking Meclizine+Pyridoxine.

Disease Interaction

Meclizine+Pyridoxine should be used with caution in patients with glaucoma, liver or kidney impairment, asthma, breathing problems, or problems with urination.

Drug Interaction

Meclizine+Pyridoxine may interact with medications such as antihistamines, antidepressants, antipsychotics, and anticonvulsants. Patients should inform their health care provider of any medications they are taking prior to taking Meclizine+Pyridoxine.

Food Interactions

Meclizine+Pyridoxine may interact with certain foods and drinks, such as alcohol, which can increase the risk of side effects. Patients should inform their health care provider of any foods or drinks they are consuming prior to taking Meclizine+Pyridoxine.

Pregnancy Use

Meclizine+Pyridoxine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Meclizine+Pyridoxine is excreted in breast milk. Mothers taking Meclizine+Pyridoxine should be closely monitored for side effects in the infant.

Acute Overdose

An acute overdose of Meclizine+Pyridoxine may result in sedation, drowsiness, and coma. Treatment is supportive.

Contraindication

Meclizine+Pyridoxine is contraindicated in patients with hypersensitivity to meclizine hydrochloride or pyridoxine, or with a history of glaucoma or urinary retention.

Use Directions

Meclizine+Pyridoxine should be taken as directed by the physician. The recommended dose is 1 tablet every 8-12 hours for adults and children 12 years of age or older, and 1 tablet 3 to 4 times daily for children 6-11 years of age. The maximum recommended daily dose is 6 tablets per day.

Storage Conditions

Meclizine+Pyridoxine should be stored at room temperature (15-30°C/59-86°F) away from light and moisture.

Volume of Distribution

The volume of distribution (Vd) of Meclizine+Pyridoxine is 0.26 L/kg.

Half-Life

The half-life of Meclizine+Pyridoxine is 8-12 hours.

Clearance

The clearance of Meclizine+Pyridoxine is 0.24 L/h/kg.

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Some Frequently Asked Questions About Meclizine + Pyridoxine

1. What is Meclizine + Pyridoxine ?

Meclizine + Pyridoxine is a combination medication used to treat nausea, vomiting, and dizziness associated with conditions like motion sickness and morning sickness during pregnancy. Meclizine is an antihistamine, while Pyridoxine is a form of Vitamin B6.

2. How does Meclizine + Pyridoxine work?

Meclizine works by blocking histamine receptors in the brain, which helps reduce symptoms of dizziness and nausea. Pyridoxine, or Vitamin B6, is believed to help reduce nausea, especially in pregnant women, by improving neurotransmitter function in the brain.

3. What is Meclizine + Pyridoxine used for?

This combination is primarily used for:

• Preventing and treating nausea and vomiting associated with motion sickness
• Managing morning sickness during pregnancy
• Alleviating dizziness or vertigo caused by inner ear problems

4. How should I take Meclizine + Pyridoxine ?

Meclizine + Pyridoxine is typically taken orally, with or without food. The dosage may vary based on the condition being treated. Commonly, it is taken once or twice daily, but you should always follow your healthcare provider's instructions regarding dosage.

5. What are the common side effects of Meclizine + Pyridoxine ?

Common side effects may include:

• Drowsiness or fatigue
• Dry mouth
• Headache
• Constipation
• Blurred vision

If any of these effects are bothersome or persist, consult your healthcare provider. Severe side effects like difficulty breathing or swelling require immediate medical attention.

6. Can I take Meclizine + Pyridoxine with other medications?

Meclizine + Pyridoxine can interact with other medications, particularly those that also cause drowsiness, such as other antihistamines, sedatives, or alcohol. Always inform your healthcare provider about any other medications you are taking to avoid harmful interactions.

7. Can I drive after taking Meclizine + Pyridoxine ?

Meclizine may cause drowsiness, so it is advisable to avoid driving or operating heavy machinery until you understand how the medication affects you. Always assess your own alertness before engaging in activities that require full concentration.

8. Can Meclizine + Pyridoxine cause an allergic reaction?

Although rare, an allergic reaction to Meclizine + Pyridoxine can occur. Symptoms of an allergic reaction may include hives, swelling of the face or throat, difficulty breathing, and rash. If you experience any of these symptoms, seek emergency medical attention immediately.

9. Can Meclizine + Pyridoxine be taken during pregnancy?

Meclizine + Pyridoxine is commonly prescribed for managing morning sickness during pregnancy, as both ingredients are generally considered safe for use. However, it is essential to consult your healthcare provider before taking any medication during pregnancy.

10. Can Meclizine + Pyridoxine be taken while breastfeeding?

Meclizine passes into breast milk in small amounts. While it is generally considered safe to use during breastfeeding, you should consult your healthcare provider to ensure this combination is appropriate for you and your baby.

11. How should I store Meclizine + Pyridoxine ?

Store Meclizine + Pyridoxine at room temperature, away from excessive heat and moisture. Keep it out of reach of children and in its original packaging to maintain effectiveness.

12. What should I do if I miss a dose of Meclizine + Pyridoxine ?

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and take the next dose at your regular time. Do not take extra medication to make up for a missed dose.

13. Can Meclizine + Pyridoxine be used for long-term treatment?

Meclizine + Pyridoxine is generally intended for short-term use to treat nausea, vomiting, and dizziness. Long-term use should only be done under the guidance of a healthcare provider to assess potential risks or side effects.

14. Can Meclizine + Pyridoxine cause drowsiness?

Yes, drowsiness is a common side effect of Meclizine. If you experience drowsiness, avoid activities that require full concentration, such as driving or using heavy machinery, until you are aware of how the medication affects you.

15. Is Meclizine + Pyridoxine safe for children?

Meclizine + Pyridoxine is generally not recommended for children under the age of 12 unless prescribed by a doctor. The safety and effectiveness for younger populations have not been established. Always consult a healthcare provider before giving this medication to children.

16. Can Meclizine + Pyridoxine be used for nausea and vomiting caused by chemotherapy?

Meclizine + Pyridoxine is not typically used for nausea and vomiting caused by chemotherapy. Other antiemetic drugs, such as ondansetron, are more commonly prescribed for chemotherapy-related nausea.

17. Can Meclizine + Pyridoxine be used for dizziness in pets?

Meclizine may sometimes be prescribed by veterinarians for dizziness in pets, but you should not give Meclizine + Pyridoxine to animals without consulting a veterinarian first.

18. How does Pyridoxine help with nausea during pregnancy?

Pyridoxine, or Vitamin B6, is commonly used to treat nausea and vomiting during pregnancy. It works by improving neurotransmitter function in the brain, which may help alleviate nausea, particularly in the early stages of pregnancy.

19. What is the difference between Meclizine + Pyridoxine and other anti-nausea medications?

Meclizine + Pyridoxine combines an antihistamine (Meclizine) with Vitamin B6 (Pyridoxine), whereas other anti-nausea medications like ondansetron work by blocking serotonin receptors. Pyridoxine is often specifically recommended for pregnant women, while Meclizine is more commonly used for motion sickness and vertigo.

20. What should I do if I overdose on Meclizine + Pyridoxine ?

If you suspect an overdose of Meclizine + Pyridoxine , seek emergency medical help immediately. Symptoms of an overdose may include severe drowsiness, dry mouth, blurred vision, and difficulty breathing.

21. Does Meclizine + Pyridoxine interact with alcohol?

Alcohol can increase the sedative effects of Meclizine, leading to excessive drowsiness and dizziness. It is advisable to avoid drinking alcohol while taking this medication to reduce the risk of side effects.

22. Can Meclizine + Pyridoxine help with dizziness caused by low blood pressure?

Meclizine + Pyridoxine may help with dizziness, but it is not specifically designed to treat low blood pressure. If your dizziness is due to low blood pressure, consult your healthcare provider for the appropriate treatment.

23. Can Meclizine + Pyridoxine cause blurry vision?

Blurred vision is a possible side effect of Meclizine, particularly due to its anticholinergic properties. If you experience blurred vision, contact your healthcare provider for further guidance.

24. Can Meclizine + Pyridoxine be used for seasickness?

Yes, Meclizine + Pyridoxine can be used to prevent and treat seasickness, as it helps to alleviate symptoms like nausea and dizziness caused by motion.

25. Can I take Meclizine + Pyridoxine if I have a history of seizures?

If you have a history of seizures, it is essential to consult your healthcare provider before taking Meclizine + Pyridoxine . The combination may interact with other medications or conditions that affect seizure control.

26. How does Meclizine help with motion sickness?

Meclizine is an antihistamine that works by blocking the effects of histamine in the brain, which is responsible for symptoms of nausea, vomiting, and dizziness associated with motion sickness.

27. How long does it take for Meclizine + Pyridoxine to work?

Meclizine + Pyridoxine typically starts working within an hour of ingestion, with the effects lasting up to 24 hours. Individual responses may vary depending on the person and the condition being treated.

28. Can I stop taking Meclizine + Pyridoxine if my symptoms improve?

It’s important to follow your doctor’s recommendations when discontinuing Meclizine + Pyridoxine . Stopping suddenly may lead to a return of symptoms, so always consult your healthcare provider before stopping or adjusting your dosage.

29. Can I take Meclizine + Pyridoxine if I have asthma?

Meclizine is generally considered safe for individuals with asthma, but you should consult your doctor before taking it to ensure it does not interact with any asthma medications you are using.

30. Can Meclizine + Pyridoxine be used for motion sickness in children?

Meclizine + Pyridoxine is generally not recommended for children under the age of 12. Always consult your doctor before giving this medication to children.

31. Can Meclizine + Pyridoxine cause constipation?

Constipation is a possible side effect of Meclizine, which can occur due to its sedative effects. If you experience constipation, increase your fiber intake, drink plenty of water, and consult your healthcare provider if necessary.

32. Can Meclizine + Pyridoxine be used for vertigo?

Yes, Meclizine is commonly used to treat vertigo, particularly when caused by inner ear disorders. Pyridoxine helps reduce nausea associated with the condition.

33. Is Meclizine + Pyridoxine safe for elderly people?

Elderly individuals may be more sensitive to the sedative effects of Meclizine. Your doctor may adjust the dosage to minimize side effects like dizziness or drowsiness.

34. Does Meclizine + Pyridoxine cause drowsiness?

Yes, one of the common side effects of Meclizine is drowsiness. You should avoid engaging in activities that require alertness, such as driving, while taking this medication.

35. Can Meclizine + Pyridoxine help with nausea caused by pregnancy-related conditions other than morning sickness?

Meclizine + Pyridoxine may help with nausea related to pregnancy, including conditions like hyperemesis gravidarum. However, it is crucial to follow your doctor’s instructions on dosage and use.

36. What should I do if I experience severe side effects from Meclizine + Pyridoxine ?

If you experience severe side effects like difficulty breathing, chest tightness, or swelling of the face, seek emergency medical help immediately.

37. How can I reduce the risk of side effects from Meclizine + Pyridoxine ?

To minimize side effects, take the medication exactly as prescribed, avoid alcohol, and avoid driving or operating heavy machinery if you feel drowsy.

38. Can I take Meclizine + Pyridoxine with food?

Yes, Meclizine + Pyridoxine can be taken with or without food. However, if you experience stomach upset, taking it with food may help.

39. Can Meclizine + Pyridoxine interact with antidepressants?

Meclizine + Pyridoxine may interact with certain antidepressants, especially those that cause drowsiness. Always inform your healthcare provider about all medications you are taking.

40. Can Meclizine + Pyridoxine be used for nausea caused by motion sickness on airplanes?

Yes, Meclizine + Pyridoxine can help prevent and treat motion sickness symptoms while traveling on airplanes, including nausea and dizziness.

41. Can Meclizine + Pyridoxine be taken if I have a heart condition?

If you have a heart condition, consult your doctor before taking Meclizine + Pyridoxine , as it may have interactions with heart medications or affect your condition.

42. Can I drink coffee while taking Meclizine + Pyridoxine ?

While there are no known interactions between coffee and Meclizine + Pyridoxine , excessive caffeine may exacerbate side effects like nervousness or restlessness. It’s best to consume coffee in moderation.

43. Can Meclizine + Pyridoxine be used to treat nausea from food poisoning?

Meclizine + Pyridoxine may help alleviate nausea from food poisoning, but it is not a treatment for the underlying cause. Hydration and rest are also essential, and you should consult a doctor if symptoms persist.

44. Does Meclizine + Pyridoxine help with dizziness caused by anxiety?

Meclizine + Pyridoxine is not intended for anxiety-induced dizziness. If anxiety is causing your dizziness, consult your doctor for appropriate treatment options.

45. How long can I take Meclizine + Pyridoxine for morning sickness?

The duration of treatment for morning sickness depends on your individual symptoms. It is typically used for short-term relief, but always consult your doctor if you need to take it for extended periods.

46. Can I take Meclizine + Pyridoxine if I am allergic to other antihistamines?

If you are allergic to other antihistamines, you should consult your healthcare provider before using Meclizine + Pyridoxine , as it may cause similar allergic reactions.

47. Can I use Meclizine + Pyridoxine for nausea from a hangover?

Meclizine + Pyridoxine may help with nausea, but it is not intended for hangover relief. Proper hydration and rest are the best ways to recover from a hangover.

48. Can I take Meclizine + Pyridoxine if I have diabetes?

Meclizine + Pyridoxine does not have direct effects on blood sugar, but you should consult your healthcare provider if you have diabetes, especially regarding other medications or potential side effects.

49. How should Meclizine + Pyridoxine be discontinued?

Discontinuing Meclizine + Pyridoxine should be done as per your healthcare provider’s instructions. Stopping abruptly is usually not recommended unless there are adverse effects.

50. Can Meclizine + Pyridoxine be used to treat dizziness caused by dehydration?

Meclizine + Pyridoxine may help manage dizziness, but dehydration must be treated with proper hydration. If dizziness persists, consult your doctor for further evaluation.