Mabic Tablet

Introduction

Mabic Tablet 100 mg is a drug used to treat several types of leukaemia and other types of cancer. It is a kinase inhibitor, meaning that it blocks certain proteins which cause cell growth to progress. It stops abnormal cells from multiplying and spreading in the body.

Uses

Mabic Tablet 100 mg is used for the treatment of chronic myeloid leukemia, Philadelphia chromosome-positive acute lymphoblastic leukemia, and acute myeloid leukemia.

Mechanism Of Action

Mabic Tablet 100 mg works by blocking certain proteins which control cancer cell growth and survival. The drug inhibits BCR-ABL, a protein that is important in the growth of cancer cells, and also targets SRC, FYN, and HCK proteins which are involved in cell division and growth. It also inhibits other protein kinases involved in angiogenesis, a process whereby new blood vessels form in the body.

How Long Does it Take to Work?

The effects of dasatinib can be seen within 48 to 72 hours of treatment, and can usually be seen within one to two weeks. Patients usually notice an improvement in symptoms as well as an increase in energy levels and improved overall health.

Absorption

Mabic Tablet 100 mg is rapidly and extensively absorbed from the gastrointestinal tract. The maximum plasma concentration of the drug is reached within two hours after oral administration.

Route Of Elimination

Mabic Tablet 100 mg is primarily eliminated in urine and faeces. Metabolites of the drug are also excreted in faeces and urine.

Dosage

The recommended dose of dasatinib is 100mg once daily, with or without food. Doses greater than 100mg are not recommended as they can cause more serious side effects. Patients with renal impairment may need to adjust the dose of dasatinib.

Administration

Mabic Tablet 100 mg should be taken orally with or without food. It can be taken with or without a meal as long as the dose is taken at the same time each day. Care should be taken to ensure that the entire dose is taken at one time as splitting doses may decrease the effectiveness of the drug.

Side Effects

Common side effects of dasatinib include nausea, diarrhoea, muscle and joint pain, fatigue, headache, constipation, rash, and fever. Other rare but serious side effects include gastrointestinal bleeding, severe blistering and peeling skin, lung infection, and liver injury.

Toxicity

Mabic Tablet 100 mg is generally safe and well tolerated but can cause serious side effects such as liver injury, severe skin reactions, and lung infection. Patients should seek medical advice if any of these side effects occur.

Precautions

Patients should notify their doctor if they are taking any other medications or have any known allergies. Patients should also inform their doctor if they become pregnant or are breast-feeding.

Interaction

Mabic Tablet 100 mg may interact with certain medications. Patients should always inform their doctor before taking any other medications, vitamins, or supplements. Certain foods and beverages may also interact with dasatinib, so it is important to discuss dietary changes with a doctor or pharmacist.

Disease Interaction

Mabic Tablet 100 mg may interact with certain diseases, such as liver or kidney disease. It is important to tell your doctor if you have any existing liver or kidney diseases, or if you have had any illnesses recently.

Drug Interaction

Mabic Tablet 100 mg may interact with certain drugs. Patients should tell their doctor if they are taking any other medications, vitamins, or supplements.

Food Interactions

Mabic Tablet 100 mg may interact with certain foods. Patients should discuss food interactions with their doctor or pharmacist. Certain beverages, such as grapefruit juice, may interact with dasatinib, so it is important to discuss any dietary changes with a doctor or pharmacist.

Pregnancy Use

Mabic Tablet 100 mg should not be used during pregnancy. It can cause harm to a developing fetus. Women who are pregnant or planning to become pregnant should tell their doctor they are taking dasatinib.

Lactation Use

It is not known if dasatinib passes into breast milk. It is important to speak to your doctor before taking dasatinib while breastfeeding.

Acute Overdose

An overdose of dasatinib can lead to serious side effects, such as gastrointestinal bleeding, severe blistering and peeling skin, lung infection, and liver injury. If you experience any of these symptoms, contact your doctor or seek medical treatment as soon as possible.

Contraindication

Mabic Tablet 100 mg should not be taken by patients with known hypersensitivity to the drug or its ingredients. It should also not be taken by patients with pre-existing liver or kidney diseases, or by patients who have had any illnesses recently.

Use Direction

Mabic Tablet 100 mg should be taken orally with or without food. Patients should take the exact dosage prescribed by their doctor, and should not split the doses. The recommended dose is 100mg once daily. Patients should not exceed the prescribed dose, as it can lead to serious side effects.