Lizorex IV Infusion

Lizorex IV Infusion 2 mg/ml Introduction

Lizorex IV Infusion 2 mg/ml is an antibiotic used to treat bacterial infections such as pneumonia, skin infections, and certain types of blood infections. It belongs to a class of drugs called oxazolidinones. It works by stopping the growth of bacteria that cause infection.

Uses for Lizorex IV Infusion 2 mg/ml

Lizorex IV Infusion 2 mg/ml is used to treat infections caused by susceptible bacteria including pneumonia, skin infections, and certain types of blood infections. It is also used to reduce the risk of infection during certain medical procedures.

Brand Name	Lizorex
Type	IV Infusion
Weight	2 mg/ml
Generic	Linezolid
Manufacturer	Beacon Pharmaceuticals PLC
Available in	English বাংলা

Mechanism of Action

Lizorex IV Infusion 2 mg/ml works by binding to and inhibiting the ribosomal protein that is responsible for the formation of proteins in bacteria. This inhibits the growth and reproduction of the bacteria, thus preventing the infection from spreading.

How Long Does It Take to Work?

Lizorex IV Infusion 2 mg/ml is usually started to work within 24 hours, although in some cases it may take up to 48 hours. It is important to complete the full course of medication as prescribed by your doctor.

Absorption

Lizorex IV Infusion 2 mg/ml is rapidly and completely absorbed from the gastrointestinal tract and has a bioavailability of approximately 100%.

Route of Elimination

Lizorex IV Infusion 2 mg/ml is predominantly eliminated via the kidneys with a small amount being metabolized and excreted in the bile.

Dosage

Linezolid tablets should be taken in oral route with or without food. Linezolid IV infusion should be administered by intravenous infusion over a period of 30 to 120 minutes. The recommended daily dosage for Linezolid tablets and IV infusion is described in the following table:


Infection	Dosage, route and frequency of administration
	Pediatric patients* (birth through 11 years of age)	Adults and adolescent (12 years and older)	Recommended duration of treatment (consecutive days)
Nosocomial pneumonia	10 mg/kg orally or intravenously every 8 hours	600 mg orally or intravenously every 12 hours	10 to 14
Community-acquired pneumonia, including concurrent bacteremia
Complicated skin and skin structure infections
Complicated skin and skin structure infections	10 mg/kg orally or intravenously every 8 hours	600 mg orally or intravenously every 12 hours	14 to 28
Uncomplicated skin and skin structure infections	less than 5 years: 10 mg/kg orally every 8 hours 5-11 years: 10 mg/kg orally every 12 hours	Adults: 400 mg orally every 12 hours Adolescents: 600 mg orally every 12 hours	10 to 14
* Neonates less than 7 days: Most pre-term neonates less than 7 days of age (gestational age less than 34 weeks) have lower systemic linezolid clearance values and larger AUC values than many full-term neonates and older infants. These neonates should be initiated with a dosing regimen of 10 mg/kg every 12 hours. Consideration may be given to the use of 10 mg/kg every 8 hours regimen in neonates with a sub-optimal clinical response. All neonatal patients should receive 10 mg/kg every 8 hours by 7 days of life.

No dose adjustment is necessary when switching from intravenous to oral administration.

Intravenous administration: Linezolid IV infusion should be inspected visually against a light source for particulate matter prior to administration. Linezolid IV infusion may exhibit a yellow color that can intensify over time without adversely affecting potency. Do not use this intravenous infusion vial in series connections. Additives should not be introduced into this solution. Discard unused portion after single use.

Hepatic impairment: No dose adjustment is recommended for patients with mild-to-moderate hepatic impairment. The pharmacokinetics of Linezolid in patients with severe hepatic impairment have not been evaluated.

Use in children and adolescents: The dose of linezolid for children and adolescents have been described in dose and administration section. The use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended

Lizorex IV Infusion 2 mg/ml is available in oral tablets and suspension. The dosage varies depending on the type of infection and the patient's response to treatment. For adults, the recommended dosage for oral tablets is 600 mg to 1200 mg twice daily. For children, the recommended dosage is 10 mg/kg to 15 mg/kg twice daily. For the suspension, it is recommended to take a dose of either 8 mg/kg to 10 mg/kg twice daily.

Administration

Lizorex IV Infusion 2 mg/ml should be taken with food and can be taken with or without water. It should be taken regularly, at the same time each day.

Side Effect

Common side effects of Lizorex IV Infusion 2 mg/ml include nausea, vomiting, diarrhea, rashes, and indigestion. Less common side effects include headaches, dizziness, insomnia, and fever. In rare cases, it can cause serious side effects such as liver damage, anemia, and low blood pressure.

Toxicity

High doses of Lizorex IV Infusion 2 mg/ml can lead to serious toxicity including changes in blood chemistry, seizures, and coma. Overuse or misuse of Lizorex IV Infusion 2 mg/ml can also lead to drug resistance, which can lead to treatment failure.

Precaution

Lizorex IV Infusion 2 mg/ml should be used with caution in patients with impaired renal or hepatic function, as it may not be as effectively removed from the body. It should also be used with caution in pregnant and breastfeeding women, and in patients with a history of seizures.

Interaction

Lizorex IV Infusion 2 mg/ml can interact with other drugs, such as tyramine-containing foods, monoamine oxidase inhibitors, and certain antibiotics, so it is important to inform your doctor about all medications you are taking before starting treatment with Lizorex IV Infusion 2 mg/ml.

Disease Interaction

Lizorex IV Infusion 2 mg/ml should be used with caution in patients with severe kidney or liver disease, as it may not be as effectively removed from the body. It should also be used with caution in patients with a history of seizures.

Drug Interaction

Food Interactions

Lizorex IV Infusion 2 mg/ml should not be taken with tyramine-containing foods, such as aged cheese, red wine, salami, liver, sauerkraut, beer, yogurt, and soy sauce. If possible, it is best to avoid these foods while taking Lizorex IV Infusion 2 mg/ml.

Pregnancy Use

Lizorex IV Infusion 2 mg/ml should be used with caution in pregnant women, as it is not known if Lizorex IV Infusion 2 mg/ml can pass through the placenta or if it has any adverse effects on the fetus.

Lactation Use

Lizorex IV Infusion 2 mg/ml should be used with caution in breastfeeding women, as it is not known if Lizorex IV Infusion 2 mg/ml can pass into breast milk. It is best to avoid breastfeeding while taking Lizorex IV Infusion 2 mg/ml.

Acute Overdose

If an overdose of Lizorex IV Infusion 2 mg/ml is suspected, contact your local poison control center or seek medical attention immediately. Symptoms of an overdose may include agitation, confusion, dizziness, abdominal pain, vomiting, and seizures.

Contraindication

Lizorex IV Infusion 2 mg/ml is contraindicated in patients who are hypersensitive to it or to any of its components.

Use Direction

Lizorex IV Infusion 2 mg/ml should be taken exactly as directed by your doctor. It is important to take it regularly at the same time each day and not to miss any doses.