Lioresal Tablet

Lioresal Tablet 25 mg

Lioresal Tablet 25 mg is a medication primarily used to treat spasticity, particularly in conditions such as multiple sclerosis and spinal cord injuries. It functions as a muscle relaxer and an antispastic agent.

Brand Name	Lioresal
Type	Tablet
Weight	25 mg
Generic	Baclofen
Manufacturer	Novartis (Bangladesh) Ltd.
Available in	English বাংলা

Mechanism of Action

Lioresal Tablet 25 mg works by activating $\text{GABA}_{\text{B}}$ receptors in the brain and spinal cord, which inhibits the release of excitatory neurotransmitters. This action reduces the activity of nerve cells that cause muscle spasticity.

Uses

Spasticity: Lioresal Tablet 25 mg is effective in reducing muscle stiffness and spasms associated with multiple sclerosis and spinal cord injuries.
Hiccups: It is sometimes used off-label to treat persistent hiccups.
Alcohol Withdrawal: Lioresal Tablet 25 mg is also used off-label to manage symptoms of alcohol withdrawal.

Side Effects

Common side effects of Lioresal Tablet 25 mg include:

Drowsiness
Dizziness
Weakness
Fatigue
Headache

Dosage

Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily.

Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose-

12 month-2 years: 10-20 mg (10-20 ml)
2 years-6 years: 20-30 mg (20-30 ml)
6 years-10 years: 30-60 mg (30-60 ml)

The dosage of Lioresal Tablet 25 mg varies based on the condition being treated and the patient’s response to the medication. It is typically started at a low dose and gradually increased.

Precautions

Kidney Function: Lioresal Tablet 25 mg is excreted by the kidneys. Patients with impaired kidney function need dose adjustments.
Abrupt Withdrawal: Stopping Lioresal Tablet 25 mg suddenly can lead to severe withdrawal symptoms, including seizures.
Alcohol and CNS Depressants: Concomitant use with alcohol or other CNS depressants can enhance the sedative effects of Lioresal Tablet 25 mg.

How Long Does It Take to Work?

Lioresal Tablet 25 mg typically begins to show its effects within a few days of starting the treatment. However, the full therapeutic effect may take up to a week or more, depending on the dosage and individual response.

Pregnancy Use

Lioresal Tablet 25 mg is classified as a Category C drug for pregnancy. This means that animal studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in humans. Lioresal Tablet 25 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Lioresal Tablet 25 mg is excreted in breast milk. Caution is advised if Lioresal Tablet 25 mg is used while breastfeeding, as it may cause sedation and other effects in the nursing infant.

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