Liorel Tablet

Liorel Tablet 5 mg

Liorel Tablet 5 mg is a medication primarily used to treat spasticity, particularly in conditions such as multiple sclerosis and spinal cord injuries. It functions as a muscle relaxer and an antispastic agent.

Mechanism of Action

Liorel Tablet 5 mg works by activating $\text{GABA}_{\text{B}}$ receptors in the brain and spinal cord, which inhibits the release of excitatory neurotransmitters. This action reduces the activity of nerve cells that cause muscle spasticity.

Uses

• Spasticity: Liorel Tablet 5 mg is effective in reducing muscle stiffness and spasms associated with multiple sclerosis and spinal cord injuries.
• Hiccups: It is sometimes used off-label to treat persistent hiccups.
• Alcohol Withdrawal: Liorel Tablet 5 mg is also used off-label to manage symptoms of alcohol withdrawal.

Side Effects

Common side effects of Liorel Tablet 5 mg include:

• Drowsiness
• Dizziness
• Weakness
• Fatigue
• Headache

Dosage

• 12 month-2 years: 10-20 mg (10-20 ml)
• 2 years-6 years: 20-30 mg (20-30 ml)
• 6 years-10 years: 30-60 mg (30-60 ml)

The dosage of Liorel Tablet 5 mg varies based on the condition being treated and the patient’s response to the medication. It is typically started at a low dose and gradually increased.

Precautions

• Kidney Function: Liorel Tablet 5 mg is excreted by the kidneys. Patients with impaired kidney function need dose adjustments.
• Abrupt Withdrawal: Stopping Liorel Tablet 5 mg suddenly can lead to severe withdrawal symptoms, including seizures.
• Alcohol and CNS Depressants: Concomitant use with alcohol or other CNS depressants can enhance the sedative effects of Liorel Tablet 5 mg.

How Long Does It Take to Work?

Liorel Tablet 5 mg typically begins to show its effects within a few days of starting the treatment. However, the full therapeutic effect may take up to a week or more, depending on the dosage and individual response.

Pregnancy Use

Liorel Tablet 5 mg is classified as a Category C drug for pregnancy. This means that animal studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in humans. Liorel Tablet 5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Liorel Tablet 5 mg is excreted in breast milk. Caution is advised if Liorel Tablet 5 mg is used while breastfeeding, as it may cause sedation and other effects in the nursing infant.

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