Introduction
Linera M Tablet 2.5 mg+1000 mg is a combination medication used to treat type 2 diabetes. The medication is a combination of the oral medications linagliptin and metformin hydrochloride. Linagliptin belongs to a class of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors, and helps lower blood sugar levels by increasing insulin release from the pancreas and decreasing glucose production in the liver. Metformin hydrochloride belongs to a class of medicines known as biguanides, and helps lower blood sugar levels by decreasing absorption of glucose from the intestine, and decreasing glucose production in the liver.Uses for
Linera M Tablet 2.5 mg+1000 mg is used to treat type 2 diabetes in adult patients aged 18 years and older who are inadequately controlled by diet and exercise alone. It is also used to improve glycemic control in adult patients with type 2 diabetes who are using a combination of linagliptin and metformin hydrochloride as separate tablets, and who have not achieved sufficient glycemic control on this combination therapy.Mechanism of Action
Linagliptin belongs to a class of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It increases insulin release from the pancreas and decreases glucose production in the liver, which helps lower blood sugar levels. Metformin hydrochloride belongs to a class of medicines known as biguanides. It decreases absorption of glucose from the intestine, and also decreases glucose production in the liver, which helps lower blood sugar levels. The combination of linagliptin + metformin hydrochloride helps to improve glycemic control in patients with type 2 diabetes by lowering fasting and post-meal plasma glucose levels.How Long Does it Take to Work?
Linera M Tablet 2.5 mg+1000 mg begins to take effect within 1–2 weeks of starting therapy, and the maximum therapeutic effect occurs after 8–10 weeks.Absorption
Linagliptin is rapidly absorbed after oral administration, with peak plasma concentrations being reached in 1–3 hours. Metformin hydrochloride is absorbed slowly and the systemic bioavailability is low. Peak plasma concentrations are achieved 4–8 hours after administration.Route of Elimination
Linagliptin is eliminated primarily through renal excretion, while metformin hydrochloride is eliminated largely through hepatic metabolism.Dosage
Linagliptin & Metformin immediate release tablet: The dosage of Linagliptin & Metformin should be individualized on the basis of both effectiveness and tolerability. Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals. Dose escalation should be gradual to reduce the gastrointestinal (GI) side effects associated with Metformin Hydrochloride use.Recommended starting dose: In patients currently not treated with Metformin Hydrochloride, initiate treatment with 2.5 mg Linagliptin and 500 mg Metformin Hydrochloride twice daily.
In patients already treated with Metformin Hydrochloride, start with 2.5 mg Linagliptin and the current dose of Metformin Hydrochloride twice daily.
Patients already treated with Linagliptin and Metformin Hydrochloride, individual components may be switched to this combination containing the same doses of each component.
Linagliptin & Metformin extend release tablet: The dosage of this combination should be individualized on the basis of both effectiveness and tolerability, while not exceeding the maximum recommended total daily dose of Linagliptin 5 mg and Metformin Hydrochloride 2000 mg. this combination should be given once daily with a meal.
Recommended starting dose: In patients currently not treated with metformin, initiate this combination treatment with 5 mg Linagliptin/1000 mg Metformin Hydrochloride extended-release once daily with a meal.
In patients already treated with Metformin, start this combination with 5 mg of Linagliptin total daily dose and a similar total daily dose of Metformin once daily with a meal.
In patients already treated with Linagliptin & Metformin immediate release tablet, switch to extend release tablet containing 5 mg of Linagliptin total daily dose and a similar total daily dose of Metformin once daily with a meal.
5 mg Linagliptin & 1000 mg Metformin Hydrochloride extended-release tablet should be taken as a single tablet once daily. Patients using 2.5 mg Linagliptin & 1000 mg Metformin extended release tablets should take two tablets together once daily. The recommended adult dosage is 1 tablet taken orally once a day, with or without food. If a dose is missed, the patient should take the next dose as soon as possible, unless it is almost time for the next dose. The patient should not double the dose.
