Linagliptin

Linagliptin Introduction

Linagliptin is an oral anti-diabetic drug for the treatment of type 2 diabetes that belongs to the dipeptidyl peptidase 4 (DPP-4) inhibitor class. It is used together with a proper diet and exercise program to control high blood sugar. It works by reducing the amount of sugar (glucose) produced by the liver. It also increases the body’s sensitivity to insulin, enabling it more effectively to lower blood sugar.

Uses

Linagliptin is used to control high blood sugar levels in adults and children with type 2 diabetes. It is generally used in combination with proper diet and exercise program.

Brand Name	Linagliptin
Type
Weight
Generic	Linagliptin
Manufacturer
Available in	English বাংলা

Mechanism of Action

Linagliptin blocks the enzyme dipeptidyl peptidase 4 (DPP-4) from breaking down the incretin hormones, which normally regulate glucose. By blocking DPP-4, Linagliptin increases levels of active incretin hormones, which reduce blood glucose.

How Long Does it Take to Work?

It may take up to 2 weeks before you notice an improvement in your blood glucose levels. Consult your doctor to determine if a change in your dosage is required.

Absorption

Linagliptin is slowly and completely absorbed from the gastrointestinal (GI) tract with peak plasma concentration achieved 0.5 to 1.5 hours after oral administration.

Route of Elimination

Linagliptin is mainly eliminated through bile as unchanged drug.

Dosage

Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly. When used in combination with a sulfonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.

Patients with renal impairment: No dose adjustment required. Linagliptin can be taken with or without a meal at any time of the day.

Linagliptin is available in tablets of 5 mg and 10 mg. The recommended adult dosage for initial therapy is 5mg orally once daily. The recommended maintenance dosage is 10mg orally once daily. The dosage may be adjusted based on the response.

Administration

Linagliptin should be taken with or without food. It should be taken at the same time, each day.

Side Effect

The most common side effects associated with linagliptin include: headache, nausea, upper respiratory infection, runny nose, sore throat, and abdominal pain. Other side effects include dizziness, muscle pain, and back pain.

Toxicity

Linagliptin is generally considered safe and well-tolerated. There have been no reported cases of significant or acute toxicity.

Precautions

Patients should inform their doctor of any medical conditions, allergies, pregnancy, and breast-feeding before taking linagliptin. Patients with kidney disease or liver problems should use this medication with caution.

Interaction

Linagliptin may interact with other medications, including oral antidiabetic drugs, stimulants, and other medications. Consult your doctor before taking linagliptin if you are taking any other medications.

Disease Interaction

Linagliptin has not been studied in patients with significant hepatic or renal impairment. Therefore, caution should be used in these patients.

Drug Interactions

Linagliptin may interact with other medications, including oral antidiabetic drugs, stimulants, and other medications.

Food Interactions

Linagliptin is not affected by food and may be taken with or without food.

Pregnancy Use

Linagliptin is a pregnancy category B drug and is suggested not to be used during pregnancy unless necessary and as determined by your doctor.

Lactation Use

Linagliptin is excreted in human milk in small amounts. The potential risk of the infant should be considered before utilizing this drug.

Acute Overdose

In clinical studies, an overdose of 400mg of Linagliptin resulted in no serious adverse reactions. Other smaller overdoses have resulted in similar results with no serious adverse reactions.

Contraindication

Linagliptin is contraindicated in patients with a known sensitivity to the active ingredient or any of the excipients.

Use Direction

Take Linagliptin exactly as prescribed by your doctor. Do not take more than the recommended dose and do not stop taking this medication abruptly unless your doctor advises you to do so.

Storage Condition

Linagliptin tablets should be stored at room temperature, away from direct light and dampness.

Volume of Distribution

The volume of distribution of linagliptin is approximately 60 L.

Half Life

The half life of linagliptin is 13-16 hours.

Clearance

The renal clearance of linagliptin is approximately 12 liters/h. The hepatic clearance is approximately 4 liters/h.

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Some Frequently Asked Questions About Linagliptin