Larimef Tablet 250 mg
Larimef Tablet 250 mg is an antimalarial drug that is used to prevent or treat malaria. It is a synthetic mescaline-related compound classified as a 4-quinolinemethanol group. It is available in oral pill form or as an injectable solution. It is especially used to prevent and treat malaria caused by Plasmodium falciparum, the parasite that causes the most severe form of malaria in humans.
Uses for Larimef Tablet 250 mg
Larimef Tablet 250 mg is used to prevent and treat malaria caused by Plasmodium falciparum. It is also used to prevent malaria in travelers to areas where the disease is prevalent. Larimef Tablet 250 mg can be used to treat individuals who have already been infected with the parasite.
| Brand Name | Larimef |
|---|---|
| Type | Tablet |
| Weight | 250 mg |
| Generic | Mefloquine |
| Manufacturer | Healthcare Pharmaceuticals Ltd. |
| Available in | English বাংলা |
Mechanism of Action
Larimef Tablet 250 mg works by preventing the growth of Plasmodium inside human red blood cells, which reduces the spread of the disease. Larimef Tablet 250 mg also interferes with the metabolic processes of the parasites, preventing them from forming important enzymes and proteins required for their survival.
How Long Does it Take to Work?
Larimef Tablet 250 mg usually takes effect within 2 hours of ingestion and can remain effective for up to 4 weeks. The risk of malaria is significantly reduced if the drug is taken every 7 days for at least 10 days before entering an endemic area. Prolonged use may also reduce the risk of pneumonitis due to Plasmodium knowlesi.
Absorption
Larimef Tablet 250 mg is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. The mean bioavailability is around 80%. Its absorption is increased when taken with food.
Route of Elimination
Larimef Tablet 250 mg is eliminated mainly through the kidneys as the unchanged drug. It is also metabolized in the liver into active and inactive metabolites.
Dosage
Adult:- Malaria prevention: 1 tablet (250 mg) once per week starting 1-2 weeks before departure and continued for 4 weeks after leaving malarious area.
- Malaria treatment: 5 tablets (5X250 mg) in a single dose (up to max. 1.5 gm) or preferably in 2 divided doses 6 to 8 hours apart.
- Malaria prevention: Approximately 5 mg/kg body weight once per week (250 mg for children weighing over 45 kg, decreasing in proportion to body weight for children weighing 45 kg or less).
- Malaria treatment: 20 to 25 mg/kg body weight which may be split into two doses 6 to 8 hours apart to reduce the occurrence or severity of adverse reactions.
Should be taken with food. Best taken with meals & a full glass of water.
Larimef Tablet 250 mg is available in 250-mg tablets or an injectable solution. The recommended dosage for adults and children is 250 mg taken orally once weekly for the prevention of malaria. For the treatment of malaria, the recommended dose is 500-mg loading dose followed by a 250-mg single dose taken by mouth once a week for 4 weeks. The dosage for the treatment of malaria may vary depending on the severity of the infection. For children, the dosage should be adjusted based on body weight.
Administration
Larimef Tablet 250 mg should be taken with food or milk to reduce stomach discomfort. Additionally, it is recommended to drink plenty of fluids to avoid dehydration when taking Larimef Tablet 250 mg. If vomiting occurs within 30 minutes of taking Larimef Tablet 250 mg, a repeat dose should be taken.
Side Effect
Larimef Tablet 250 mg may cause a number of mild to moderate side effects including nausea, vomiting, dizziness, headache, stomach cramps, loss of appetite, and diarrhea. More serious side effects include unusual behavior or psychosis, seizures, visual disturbances, and cardiac arrhythmias. It is important to contact the doctor immediately if any of these symptoms occur.
Toxicity
Larimef Tablet 250 mg is generally not toxic when taken as prescribed. The most common side effect is nausea and vomiting. Overdose of Larimef Tablet 250 mg can cause vomiting, tremors, convulsions,nervousness, increased heart rate, and irregular heartbeats. If any of these symptoms occur, contact a poison control center immediately.
Precaution
Larimef Tablet 250 mg should not be taken by individuals with a known allergy to the drug or its components. Additionally, Larimef Tablet 250 mg should be used with caution in people with a history of seizures, depression, renal or hepatic impairment, cardiac arrhythmias, and other psychiatric conditions. It is also important to take extra precautions when taking Larimef Tablet 250 mg in combination with other medications. Inform your doctor if you are taking any other medications before taking Larimef Tablet 250 mg.
Interaction
Larimef Tablet 250 mg interacts with certain antibiotics, antifungals, and other antimalarial drugs. Additionally, Larimef Tablet 250 mg can interact with different drugs, such as warfarin, cytochrome P4503A, and protease inhibitors, that can reduce or increase its effectiveness. Therefore, it is important to inform your doctor about all of the medications you are taking before starting Larimef Tablet 250 mg.
Disease Interaction
Larimef Tablet 250 mg is not recommended for individuals with a history of seizures or neuropsychiatric disorders as it can worsen existing neurological conditions. Additionally, Larimef Tablet 250 mg is not recommended for patients with hepatic or renal impairment, as it can cause an accumulation of the drug in the body, leading to an increased risk of adverse reactions.
Drug Interaction
Larimef Tablet 250 mg may interact with other medications, such as antibiotics, antifungals, antidepressants, antacids, or anticonvulsants. Inform your doctor about all medications you are on before starting Larimef Tablet 250 mg. In addition, using Larimef Tablet 250 mg concurrently with certain drugs, such as warfarin, cytochrome P4503A, or protease inhibitors, can lead to an increased risk of adverse reactions.
Food Interactions
Larimef Tablet 250 mg is best taken with food to reduce potential side effects such as nausea and vomiting. Additionally, Larimef Tablet 250 mg can interact with certain foods, such as grapefruit juice or dairy products. Inform your doctor if you plan on eating any of these foods while taking Larimef Tablet 250 mg.
Pregnancy Use
Larimef Tablet 250 mg should not be used during pregnancy unless the potential benefits outweigh the risks. It is classified as an FDA Category C drug, which means that animal studies have shown adverse effects and there is a lack of sufficient data on humans. Therefore, it is recommended to discuss the risks and benefits with your doctor before taking Larimef Tablet 250 mg.
Lactation Use
Larimef Tablet 250 mg passes into breast milk and can have adverse effects on an infant. It is therefore not recommended to take Larimef Tablet 250 mg while breastfeeding unless the potential benefits outweigh the risks. Consult your doctor for more information.
Acute Overdose
Acute overdose of Larimef Tablet 250 mg can result in dizziness, drowsiness, confusion, agitation, and gastrointestinal disturbances. It is important to seek medical assistance as soon as possible if an overdose is suspected.
Contraindication
Larimef Tablet 250 mg is contraindicated in individuals with a known allergy to the drug or its components. It should also not be taken by people with a history of seizures, depression, renal or hepatic impairment, cardiac arrhythmias, and other psychiatric conditions. Additionally, Larimef Tablet 250 mg should not be taken during pregnancy or by breastfeeding mothers.
Use Direction
Larimef Tablet 250 mg should be taken by mouth with food or milk. For the prevention of malaria, the recommended dosage for adults and children is 250 mg taken orally once weekly. For the treatment of malaria, the recommended dose is 500-mg loading dose followed by a 250-mg single dose taken orally once a week for 4 weeks. The dosage for children should be adjusted based on body weight. If vomiting occurs within 30 minutes of taking Larimef Tablet 250 mg, a repeat dose should be taken.
Storage Condition
Larimef Tablet 250 mg oral tablets should be stored at room temperature away from direct sunlight, moisture, and heat. In addition, the injectable solution should be stored at or below 20°C (68°F).
Volume of Distribution
The volume of distribution of Larimef Tablet 250 mg is 0.35-0.7 L/kg.
Half Life
The half-life of Larimef Tablet 250 mg is 7-41 days.
Clearance
Larimef Tablet 250 mg is eliminated mainly through the kidneys as the unchanged drug. It is also metabolized in the liver into active and inactive metabolites.
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