Lanthanum Carbonate

Lanthanum Carbonate Introduction

Lanthanum carbonate is a phosphate binder medication used for the treatment of chronic kidney disease (CKD). It is used to reduce high levels of phosphorus in the blood of patients with kidney failure who are on dialysis.

Uses for Lanthanum Carbonate

Lanthanum carbonate is used to bind dietary phosphorus in patients with CKD on dialysis and is also used for the long-term management of high phosphate levels in the blood. Lanthanum carbonate helps to reduce phosphate levels in the blood and thereby prevents related health risks such as mineral and bone disorder (a disorder related to elevated phosphate levels).

Brand Name	Lanthanum Carbonate
Type
Weight
Generic	Lanthanum Carbonate
Manufacturer
Available in	English বাংলা

Mechanism of Action

Lanthanum carbonate acts by binding non-heme dietary phosphorus in the digestive tract, thereby preventing its absorption and excretion via the kidneys. The binding of non-heme dietary phosphorus helps to normalize the balance of phosphate in the blood.

How Long Does It Take to Work?

Lanthanum carbonate begins to work within 1 to 2 hours of taking it. It reaches peak effectiveness within 12 to 24 hours. For long-term control of high phosphate levels, it is important to take lanthanum carbonate regularly so that phosphate levels are kept at a normal level.

Absorption, Route of Elimination, Volume of Distribution & Half-Life

Lanthanum carbonate is poorly absorbed in the body and it is eliminated mainly through the feces. The volume of distribution of lanthanum carbonate is 17.2 L/kg and its elimination half-life is approximately 25.5 hours. Its clearance rate is 4.2 L/h.

Dosage and Administration

The recommended dosage of lanthanum carbonate is 1 gram for adult patients taken orally, once/day, at least 2 hours before or after meals. For pediatric patients, the dosage should be adjusted according to their age and weight. The duration of treatment should not exceed 8 weeks.

Side Effects

The most common side effects associated with the use of lanthanum carbonate are constipation, nausea, abdominal pain, and diarrhea. Other rare side effects may include fever, chest pain, dizziness, and difficulty breathing.

Toxicity

Lanthanum carbonate is generally well-tolerated and toxicity is rare. The drug has been tested in animals with no sign of toxicity or adverse effects.

Precaution

It is important to inform your physician about any medical conditions, such as renal impairment, before taking lanthanum carbonate. The patient should also inform the pharmacist or physician if they are taking any other medications, vitamins, or supplements, as there may be a possible interaction.

Interaction

Lanthanum carbonate may interact with certain medications such as ciprofloxacin, phenytoin, and warfarin. The patient should inform their physician of any additional medication they may be taking to be sure there is no interaction before taking lanthanum carbonate.

Disease Interaction

A disease or condition that causes an increase in phosphorus levels may potentiate adverse effects of lanthanum carbonate. This medication is generally not recommended for use in patients with end-stage renal disease (ESRD) or in patients on regular hemodialysis.

Food Interactions

The absorption of lanthanum carbonate is reduced when taken with food and other liquids. Patients should take this medication at least 1 hour before or 2 hours after eating or drinking.

Pregnancy Use

The use of lanthanum carbonate is not recommended during pregnancy due to lack of data. Patients who become pregnant or are planning to become pregnant should consult their physician before taking lanthanum carbonate.

Lactation Use

The use of lanthanum carbonate is not recommended in patients who are breastfeeding due to lack of data. Patients who are breastfeeding should consult their physician before taking lanthanum carbonate.

Acute Overdose

The symptoms of an acute overdose with lanthanum carbonate may include: nausea, diarrhea, abdominal pain, constipation, and dizziness. If an overdose occurs, the patient should seek medical attention immediately.

Contraindications

Lanthanum carbonate should not be used in patients who are hypersensitive to any ingredients in the drug. It should also not be used in patients with renal impairment.

Use Direction

Lanthanum carbonate should be taken exactly as directed by the physician. Patients should not take more or less than the prescribed dosage and should not take this medication for longer than prescribed.

Storage Condition

Lanthanum carbonate should be stored at room temperature in a dry and cool place. Keep this medication away from heat and light and out of the reach of children.

Clearance

The clearance rate of lanthanum carbonate is 4.2 L/h. In other words, lanthanum carbonate is eliminated from the body at a rate of 4.2 liters per hour.

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