Lanoxin Tablet

Introduction

Lanoxin Tablet 0.25 mg is a drug used to treat heart conditions such as congestive heart failure (CHF) and atrial fibrillation (AF). It is a classical cardiac glycoside extracted from the foxglove plant, which affects the contractility of heart muscle by combining to sodium-potassium pumps on the cell membrane of muscle fibers. Lanoxin Tablet 0.25 mg was first discovered in the late 1700s and has been used as a heart stimulant since the 1800s.

Uses

Lanoxin Tablet 0.25 mg is used for both the treatment of congestive heart failure and atrial fibrillation. It can be used to strengthen the contractility of the heart, slow the heart rate for atrial fibrillation, and help reduce the risk of stroke. It is sometimes used in combination with other medications for heart failure, such as diuretics.

Brand Name	Lanoxin
Type	Tablet
Weight	0.25 mg
Generic	Digoxin
Manufacturer	GlaxoSmithKline
Available in	English বাংলা

Mechanism of Action

Lanoxin Tablet 0.25 mg works by increasing the contractility of the heart muscle. It does this by binding to the sodium-potassium pumps on the myocardial cell membranes and increasing the amount of calcium available for myocardial contraction, which in turn increases cardiac output and improves cardiac performance. Lanoxin Tablet 0.25 mg also slows the heart rate by inhibiting the action of the SA node. Additionally, it can reduce blood pressure and improve serum electrolyte levels.

How Long Does It Take To Work?

The effects of digoxin can be felt soon after starting the treatment. However, it may take some weeks for the drug to reach its full effect. If you have further questions related to how quickly the drug will work for your particular condition, please consult your physician.

Absorption

Lanoxin Tablet 0.25 mg is absorbed rapidly from the gastrointestinal tract, with absorption increasing in an acidic environment. Peak plasma concentration of the drug is typically achieved 1-2 hours after administration. If the drug is taken with food, absorption may be delayed.

Route of Elimination

Lanoxin Tablet 0.25 mg is primarily eliminated by the kidneys. Approximately 70-80% of a dose administered orally is eliminated by the kidneys with a half-life of approximately 36 hours.

Dosage

The dosage of digoxin is determined by the severity of the condition and the age of the patient. The usual starting dose for CHF is 0.125 mg once daily. For AF, the usual starting dose is 0.125-0.25 mg once daily.

Administration

Lanoxin Tablet 0.25 mg is a tablet for oral administration. Tablets may be swallowed whole, or they can be crushed and mixed with a small amount of food, then swallowed. For pediatric patients, the tablets can be compounded into an oral liquid.

Side Effect

Lanoxin Tablet 0.25 mg can cause various side effects, including nausea, vomiting, loss of appetite, confusion, fatigue, and visual disturbances. Other rare, though more serious, side effects may include confusion, yellowing of the skin and eyes, heart rhythm changes, and an irregular heartbeat. If you experience any of these or other unusual reactions while taking this drug, please contact your doctor.

Toxicity

Lanoxin Tablet 0.25 mg toxicity may occur if the drug is used in too high of a dose or in individuals that have limited ability to metabolize the drug. Symptoms of digitalis toxicity include nausea, vomiting, headache, dyspnea, confusion, blurred vision, enlarged pupils, slowed heart rate, and rhythm disturbances. If you experience any of these symptoms, contact your doctor immediately.

Precaution

Patients receiving digoxin should be monitored closely for signs of toxicity, electrolyte imbalances, and underlying heart conditions. Patients should also have regular ECG, electrolyte, and renal function tests while taking digoxin. It is important to tell your doctor of any allergies you may have to this medication.

Interactions

Lanoxin Tablet 0.25 mg has been known to interact with certain drugs, such as diuretics, amiodarone, and quinidine. Additionally, certain medications, such as ACE inhibitors, antacids, and calcium blockers, can increase the effects of digoxin. Before taking this drug, please make sure to inform your doctor of any and all medications you are taking. Additionally, certain foods, such as grapefruit, can interact with digoxin.

Disease Interaction

Lanoxin Tablet 0.25 mg can interact with certain diseases or medical conditions. It can lead to increased risk of toxic effects from digoxin in patients with liver or kidney disease, diabetes, or electrolyte imbalances. It can also cause negative effects in patients with certain heart conditions, such as congestive heart failure. It is important to tell your doctor of any chronic medical conditions you may have before starting this medication.

Drug Interaction

Lanoxin Tablet 0.25 mg can interact with certain drugs, such as diuretics, amiodarone, quinidine, ACE inhibitors, antacids, and calcium blockers, increasing the risk of toxic effects. Furthermore, certain grapes can increase serum levels of digoxin. It is important to inform your doctor of any drugs you are taking before taking digoxin.

Food Interactions

Certain foods have been known to interact with digoxin. Grapes, grapefruit, and orange juice can increase the amount of digoxin in the bloodstream, while licorice can decrease the amount of drug absorbed. Other foods, such as coffee, have no clinically significant interactions with this drug.

Pregnancy Use

Lanoxin Tablet 0.25 mg has been assigned to pregnancy category C by the FDA. Animal studies have shown evidence of fetal risk, however, there are no controlled data in human pregnancy. This drug should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.

Lactation Use

It is not known if digoxin is excreted in human milk. Because many drugs are excreted in breast milk, caution should be exercised when administering this drug to a nursing woman.

Acute Overdose

Signs and symptoms of acute overdose include nausea, vomiting, confusion, visual disturbances, and arrhythmias. If an overdose is suspected, please contact your physician or seek medical attention immediately.

Contraindications

Lanoxin Tablet 0.25 mg should not be used in patients with heart failure caused by pre-excitation, known hypersensitivity to the active substance, or in patients with cardiac arrest. Women in the late stages of pregnancy should also not take this drug.

Use Direction

Lanoxin Tablet 0.25 mg should be taken orally exactly as prescribed by your doctor. Do not take more or less of the medication than prescribed. Do not stop taking the medication suddenly unless directed by your doctor. The tablets can be taken with or without food. To minimize the risk of adverse effects, it is important to take the medication as directed.

Storage Condition

Lanoxin Tablet 0.25 mg tablets should be stored at room temperature (68° to 77°F, 20° to 25°C), away from moisture and light. Keep the tablets securely closed in their original container, and keep out of the reach of children.

Volume of Distribution

The volume of distribution of digoxin is 2.3-3.0 L/kg.

Half Life

The half-life of digoxin in an adult is on average 1-2 days. In elderly patients, the half-life can be doubled, and in people with severe renal impairment, it can be up to 20 days.