Introduction
Lafrost Cream 10% is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Lafrost Cream 10% inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Uses
Lafrost Cream 10% is an antiviral used to treat orofacial herpes sores.
For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters).
Associated Conditions
Pharmacodynamics
Lafrost Cream 10% is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Lafrost Cream 10% speeds the healing of cold sores and fever blisters on the face or lips. It also relieves the accompanying symptoms, including tingling, pain, burning, and itching. Lafrost Cream 10% cannot, however, prevent cold sores or fever blisters from appearing.
Mechanism of Action
Lafrost Cream 10% works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.
Absorption
Topical absorption has been shown to be minimal under conditions reflecting normal clinical use.
Toxicity
Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
Food Interactions
No interactions found.
