Itracon Capsule

Itracon Capsule 200 mg

Itracon Capsule 200 mg, marketed under the brand names Sporanox and Onmel, is an antifungal prescription medication used to treat a variety of fungal infections. Itracon Capsule 200 mg belongs to a class of medications called azole antifungals, which work by blocking the growth of certain types of fungi.

Uses For

Itracon Capsule 200 mg is used to treat a variety of fungal infections, including, but not limited to, aspergillosis, blastomycosis, histoplasmosis, and cryptococcosis. It is also used to treat fungal nail infections.

Brand Name	Itracon
Type	Capsule
Weight	200 mg
Generic	Itraconazole
Manufacturer	Navana Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Itracon Capsule 200 mg works by interfering with the fungal cell membrane, preventing the absorption of essential nutrients. It slows the growth and spread of the fungus, allowing the body's immune system to fight the infection.

How Long Does It Take to Work?

Itracon Capsule 200 mg begins to work immediately after being taken, although it may take several weeks for symptoms to improve. It is important to complete the entire course of treatment to ensure that the infection is completely eliminated.

Absorption

Itracon Capsule 200 mg is well absorbed and highly soluble in water. It is typically absorbed within 30 minutes to 1 hour of taking the medication.

Route of Elimination

Itracon Capsule 200 mg is metabolized by the liver and then excreted in the urine and feces.

Dosage

100 & 200 mg preparation:
For non-systemic fungal disease-

• Vulvovaginal candidiasis: 200 mg twice daily for 01 day
• Pityriasis versicolor: 200 mg once daily for 07 days
• Tinea corporis, tinea cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days
• Tinea pedis, tinea manuum: 100 mg once daily for 30 days
• Oropharyngeal candidiasis: 100 mg once daily for 15 days, Increase dose to 200 mg once daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
• Onychomycosis (toenails with or without fingernail involvement): Either 200 mg daily for 3 months or course (pulse) of 200 mg twice daily for 7 days, subsequent courses repeated after 21 days' interval. Fingernails two courses, toenails three courses.

For systemic fungal disease-

• Aspergillosis: 200 mg once daily for 2-5 months Increase dose to 200 mg twice daily in case of invasive or disseminated disease
• Candidiasis: 100-200 mg once daily for 3 weeks-7 months. Increase dose to 200 mg twice daily in case of invasive or disseminated disease
• Non-meningeal Cryptococcosis: 200 mg once daily for 10 weeks
• Cryptococcal meningitis: 200 mg twice daily for 2-6 months
• Histoplasmosis: 200 mg once daily twice daily for 8 months
• Maintenance in AIDS: 200 mg once daily until immune recovery
• Prophylaxis in neutropenia: 200 mg once daily until immune recovery

The dose and duration of treatment for systemic antifungal disease should be adjusted depending on the clinical response.

65 mg & 130 mg preparation:
For non-systemic fungal disease-

• Vulvovaginal candidiasis: 130 mg twice daily for 1 day
• Pityriasis versicolor: 65 mg twice daily for 7 days
• Tinea corporis and tinea cruris: 65 mg daily for 15 days OR 65 mg twice daily for 7 days
• Tinea pedis and tinea manuum: 65 mg once daily for 30 days
• Oropharyngeal Candidiasis: 65 mg once daily for 15 days, increase dose to 65 mg twice daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
• Onychomycosis (toenails with or without fingernail involvement): Either 65 mg twice daily for 3 months or course (pulse) of 130 mg twice daily for 7 days, subsequent courses repeated after 21 days interval. Fingernails two courses, toenails three courses.

For systemic fungal disease-

• Aspergillosis: 65 mg twice daily for 2-5 months.Increase dose to 130 mg twice daily in case of invasive or disseminated disease
• Candidiasis: 65-130 mg once daily for 3 weeks-7 months. Increase dose to 65 mg twice daily in case of invasive or disseminated disease
• Non-meningeal Cryptococcosis: 65 mg twice daily for 10 weeks
• Cryptococcal meningitis: 130 mg twice daily for 2-6 months
• Histoplasmosis: 130 mg once daily-twice daily for 8 months
• Maintenance in AIDS: 65 mg twice daily until immune recovery
• Prophylaxis in neutropenia: 65 mg twice daily until immune recovery

The dose and duration of treatment for systemic anti-fungal disease should be adjusted depending on the clinical response.

pediatric use: The efficacy and safety of the Itraconazole capsule have not been established in pediatric patients.

The recommended dosage of itraconazole depends on the patient's age and the type and severity of the condition being treated. The usual adult dosage is 200 mg, taken once or twice daily. In some cases, doses may be increased up to 400 mg per day. The usual dosage in children 12 and older is 200 mg per day.

Administration

Itracon Capsule 200 mg should be taken with food. The capsules should be swallowed whole, not chewed or opened. Liquid formulations should be taken with food or immediately after meals.

Side Effect

Common side effects of itraconazole include nausea, vomiting, abdominal pain, headache, dizziness, rash, and insomnia. If any of these side effects persist or worsen, patients should seek medical attention.

Toxicity

Itracon Capsule 200 mg can cause serious adverse reactions when taken in large doses. In rare cases, it can cause liver failure or abnormal liver function tests. Patients who experience any signs of liver damage should seek medical attention immediately.

Precautions

Itracon Capsule 200 mg should be used with caution in individuals with liver or kidney disease, heart disease, or a history of drug-induced liver injury. It should not be used in pregnant women or nursing mothers.

Interactions

Itracon Capsule 200 mg should not be used simultaneously with certain other medications, including some anticoagulants, certain antiarrhythmics, and certain antibiotics. Patients should discuss all the medications they take with their healthcare provider.

Disease Interactions

Itracon Capsule 200 mg should not be used in patients with certain medical conditions, including liver disease and congestive heart failure. Patients with certain diseases may be at higher risk for adverse reactions to the medication.

Drug Interactions

Itracon Capsule 200 mg may interact with other medications, affecting their effectiveness or causing adverse reactions. Patients should discuss all medications they take with their healthcare provider.

Food Interactions

Itracon Capsule 200 mg may interact with certain medications and foods. Foods that contain calcium, magnesium, iron, or aluminum may reduce the absorption of itraconazole, and should be avoided within 3 hours before or after taking it. Foods that contain high amounts of fat, sugar, or starch should also be avoided.

Pregnancy Use

Itracon Capsule 200 mg should not be used during pregnancy unless it is clearly necessary. Women who are pregnant or planning to become pregnant should discuss the use of this medication with their healthcare provider.

Lactation Use

Itracon Capsule 200 mg should not be used during lactation unless it is clearly necessary. Women who are breastfeeding should discuss the use of this medication with their healthcare provider.

Acute Overdose

An acute overdose of itraconazole can cause serious symptoms, such as nausea, vomiting, abdominal pain, dizziness, and seizures. If an overdose is suspected, immediate medical treatment should be sought.

Contraindication

Itracon Capsule 200 mg should not be used in patients with known hypersensitivity to it or other azole antifungal medications.

Use Direction

Itracon Capsule 200 mg should be taken exactly as directed by a healthcare provider. The dosage and duration of treatment should not be altered without consulting a doctor.

Storage Condition

Itracon Capsule 200 mg should be stored at room temperature away from light and moisture. It should be kept out of the reach of children.

Volume of Distribution

Itracon Capsule 200 mg has a volume of distribution of 16.1 liters.

Half Life

Itracon Capsule 200 mg has an elimination half-life of 36 hours.

Clearance

Itracon Capsule 200 mg has an estimated total clearance of 146 ml/min.

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