Isotretinoin

Isotretinoin Introduction

Isotretinoin (INN, ) (earlier known as Accutane, Roaccutane, Claravis, Amnesteem, Decutan, Isotane, Sotret and Oratane) is a prescription-only medication and is an extremely effective treatment for severe acne. It is a drug derived from Vitamin A and belongs to a class of drugs called retinoids.

Uses For

Isotretinoin is used to treat severe types of acne such as nodular or cystic acne which has not responded to other treatments. It can also be used to treat a range of other skin conditions including the signs of sun damage, age spots and other pigmentation disorders.

Brand Name	Isotretinoin
Type
Weight
Generic	Isotretinoin
Manufacturer
Available in	English বাংলা

Mechanism of Action

The exact mechanism of action is not known, but it is thought to work by reducing levels of oils in the skin. This helps to reduce inflammation and prevent the formation of new acne lesions. It also helps to reduce the size of existing lesions and improve skin tone.

How Long Does It Take to Work?

Isotretinoin usually begins to work within 1-2 weeks, but it can take a few months to achieve the full benefit of the medication. It is important that patients follow their doctor's instructions in order to get the most out of the medication.

Absorption

Isotretinoin is rapidly and completely absorbed in the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration. The absorption is not affected by food.

Route of Elimination

Isotretinoin is eliminated from the body primarily by the liver. It is also eliminated through the bile and kidneys.

Dosage

Isotretinoin is available in capsules of 10mg, 20mg and 40mg. The recommended starting dose is 0.5-1mg/kg per day for the first four months and should be adjusted according to response. For most patients, the initial dose of 20mg per day is usually sufficient however some might require higher doses. It is important that the dosage is adjusted according to patient response and monitored by your doctor.

Administration

Isotretinoin is taken as a single daily dose with or without food. It is important to take the medication at the same time every day to achieve it's full therapeutic effect.

Side Effect

Common side effects of Isotretinoin include: dryness of the skin and mucous membranes, muscle and joint pain, hair loss, elevated liver enzyme levels, itching, rash, and nose bleeds. Serious side effects include depression, psychosis, and increased risk of birth defects.

Toxicity

Isotretinoin is considered to be a relatively safe drug but can be toxic in high doses or if taken for long periods of time. It is important to follow the doctor's instructions when taking this medication in order to minimize potential risks.

Precaution

Before taking isotretinoin, patients should consult their doctor about any medical conditions they may have. Women who are pregnant or planning on becoming pregnant should avoid taking isotretinoin as it can cause birth defects. Isotretinoin can cause vision problems, so special precautions may be necessary when driving or operating machinery.

Interaction

Isotretinoin can interact with other medications such as antibiotics, antifungal drugs, vitamin A, St. John's wort and birth control pills. Patients should consult their doctor before taking any other medications while on isotretinoin.

Disease Interaction

Isotretinoin can interact with other medical conditions such as diabetes, asthma, or depression. Patients should inform their doctor of any existing medical conditions before taking isotretinoin.

Drug Interaction

Isotretinoin can interact with other drugs such as birth control pills, antibiotics, antifungal drugs, vitamin A, and St. John's wort. It is important to inform your doctor of any other drugs you are taking before taking isotretinoin.

Food Interactions

Isotretinoin can interact with certain foods such as dairy products, kefir, citrus, and chili peppers which may increase the risk of side effects such as dryness and irritation. Patients should avoid these foods when taking isotretinoin.

Pregnancy Use

Isotretinoin should not be used by pregnant women as it can cause birth defects. Women who are planning to become pregnant should avoid taking this medication.

Lactationuse

Isotretinoin is not recommended for nursing mothers due to the risk of side effects in the infant. Women who are breastfeeding should avoid taking this medication.

Acute Overdose

In case of an acute overdose, the patient should seek medical attention right away. Signs and symptoms of overdose may include severe abdominal pain, vomiting, diarrhea, and low blood pressure.

Contraindication

Isotretinoin is contraindicated in people who are sensitive to it or its ingredients, or who have any other allergy. It is also contraindicated in pregnant women, nursing mothers, or people with severe liver disease.

Use Direction

It is important to follow the doctor’s instructions for taking isotretinoin. The tablets should be taken as a single daily dose with or without food. It is important to take the medication at the same time each day for the best effect.

Storage Condition

Isotretinoin capsules should be stored in a cool, dry place away from direct sunlight. It is important to keep the capsules in their original container, tightly closed and out of reach of children.