Introduction
Imnoc Tablet 25 mg is a tricyclic antidepressant (TCA) used primarily to treat major depressive disorder, enuresis (bedwetting), and certain anxiety disorders. It works by restoring the balance of neurotransmitters in the brain, particularly norepinephrine and serotonin.
Uses
Imnoc Tablet 25 mg is used for:
- Treatment of major depressive disorder (MDD)
- Treatment of childhood enuresis (bedwetting)
- Treatment of anxiety disorders and panic disorders
- Sometimes used off-label for chronic pain management
| Brand Name | Imnoc |
|---|---|
| Type | Tablet |
| Weight | 25 mg |
| Generic | Imipramine Hydrochloride |
| Manufacturer | UniMed UniHealth |
| Available in | English বাংলা |
Mechanism of Action
Imnoc Tablet 25 mg inhibits the reuptake of norepinephrine and serotonin at the synaptic cleft, enhancing their levels and prolonging their effects in the brain. This increased neurotransmitter activity is believed to improve mood and alleviate depressive symptoms.
How Long Does It Take to Work?
The therapeutic effects of Imnoc Tablet 25 mg in treating depression may take 2-4 weeks to manifest. For enuresis, improvement may be seen within a few days to weeks. The onset of action varies depending on the condition being treated.
Absorption
Imnoc Tablet 25 mg is well absorbed after oral administration. It undergoes significant first-pass metabolism in the liver, which reduces the bioavailability of the drug.
Route of Elimination
Imipramine is metabolized in the liver and excreted primarily via the kidneys in the form of inactive metabolites. A small portion is excreted unchanged in the urine.
Dosage
Depression:- Initially up to 75 mg daily in divided doses increased gradually to 150-200 mg (up to 300 mg in hospital patients)
- Up to 150 mg may be given as a single dose at bedtime
- Elderly initially 10 mg daily, increased gradually to 30-50 mg daily
- Child not recommended for depression
- Child 7-8 years: 25 mg
- 8-11 years: 25-50 mg
- Over 11 years: 50-75 mg at bedtime; max
The dosage of Imnoc Tablet 25 mg varies based on the condition being treated:
- For depression: Initial dose of 75 mg per day, which can be increased to 150-200 mg per day.
- For enuresis: 25-75 mg at bedtime depending on the child's age and response.
- For anxiety: Typically 75-150 mg per day.
Administration
Imnoc Tablet 25 mg is usually administered orally in the form of tablets or capsules. It is generally taken once or twice a day, with or without food, based on the doctor’s instructions. For enuresis, it is usually taken at bedtime.
Side Effects
Common side effects of Imnoc Tablet 25 mg include dry mouth, dizziness, drowsiness, weight gain, constipation, blurred vision, and urinary retention. Serious side effects may include arrhythmias, seizures, and hypotension.
Toxicity
Imipramine overdose can be fatal due to its cardiotoxic effects. Symptoms of overdose include seizures, arrhythmias, severe hypotension, respiratory depression, and coma. Immediate medical intervention is necessary in cases of overdose.
Precautions
Patients with a history of cardiovascular disease, glaucoma, seizures, or urinary retention should use Imipramine with caution. The drug should be discontinued gradually to avoid withdrawal symptoms, especially if used for a long period.
Interactions
Imnoc Tablet 25 mg may interact with:
- MAO inhibitors: Can cause serious interactions such as hypertensive crises.
- SSRIs: May increase the risk of serotonin syndrome.
- Anticholinergics: May increase the risk of severe constipation, urinary retention, and dry mouth.
- Alcohol and CNS depressants: Can enhance sedation and respiratory depression.
Disease Interaction
Imipramine should be used cautiously in patients with cardiovascular disease, as it may exacerbate arrhythmias or cause hypotension. Patients with seizure disorders should also use it cautiously due to the potential for lowering the seizure threshold.
Drug Interaction
Imnoc Tablet 25 mg interacts with other drugs that affect the central nervous system (e.g., benzodiazepines, antipsychotics, and sedatives), potentially leading to increased sedation. Concurrent use with MAO inhibitors or SSRIs is contraindicated due to the risk of severe interactions.
Food Interactions
Food does not significantly affect the absorption of Imipramine, though taking it with meals can help minimize gastrointestinal discomfort. Patients are advised to avoid alcohol, as it may enhance the sedative effects of the drug.
Pregnancy Use
Imnoc Tablet 25 mg should be used during pregnancy only if the potential benefits outweigh the risks. It is classified as a Category C drug, indicating that there is insufficient evidence regarding its safety during pregnancy.
Lactation Use
Imnoc Tablet 25 mg is excreted in breast milk and may cause adverse effects in nursing infants, including sedation and poor feeding. Caution is advised when administering to breastfeeding mothers.
Acute Overdose
Acute overdose of Imipramine can result in life-threatening arrhythmias, seizures, severe hypotension, and coma. Immediate medical attention, including gastric lavage and supportive care, is required to manage overdose.
Contraindications
Imnoc Tablet 25 mg is contraindicated in patients with recent myocardial infarction, uncontrolled narrow-angle glaucoma, or hypersensitivity to tricyclic antidepressants. It should not be used in combination with MAO inhibitors.
Use Direction
Imipramine should be taken as prescribed by a healthcare provider. Patients are advised to take it consistently at the same time each day. Abrupt discontinuation should be avoided due to the risk of withdrawal symptoms.
Storage Conditions
Imnoc Tablet 25 mg should be stored at room temperature, away from moisture and heat. Keep out of reach of children and pets.
Volume of Distribution
The volume of distribution of Imipramine is relatively large, indicating that the drug extensively distributes into tissues, including the brain, fat, and muscle tissue.
Half Life
The half-life of Imipramine is approximately 10-20 hours, though this may be longer in the elderly and those with impaired hepatic function.
Clearance
Imipramine is primarily metabolized by the liver, and its clearance is dependent on hepatic function. Renal clearance is also a route of elimination for its metabolites.
See in details version Imnoc Tablet 25 mg also Imnoc Tablet 25 mg in bangla
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