IMMUNOHBs Injection

Introduction

Hepatitis B immune globulin (HBIG) is a medication used to treat and prevent infection with the hepatitis B virus (HBV). It contains antibodies from the blood of healthy donors that can help protect against HBV infection. It is usually given as an injection into a muscle or below the skin.

Uses

HBIG is used to prevent and treat hepatitis B infection. It is usually given if a person has been exposed to the hepatitis B virus and is at risk of developing an infection. It can also be used to reinforce immunity when a person is about to undergo a medical procedure or to treat chronic hepatitis B infection in combination with antiviral medications.

Brand Name	IMMUNOHBs
Type	Injection
Weight	180 IU/ml
Generic	Hepatitis b immune globulin
Manufacturer	ZAS Corporation
Available in	English বাংলা

Mechanism of Action

HBIG works by providing immunity against HBV infection. It contains antibodies to the virus that can help protect against infection. The antibodies bind to the virus and can prevent it from entering cells and replicating, thereby limiting the spread of the infection.

How Long Does it Take to Work?

HBIG is usually effective at preventing infection within 24 hours of administration if given shortly after exposure. To maintain sufficient levels of antibodies, a person may need to receive multiple doses of HBIG over a period of time.

Absorption

HBIG is administered by injection and does not need to be absorbed into the body. It works immediately and does not need to be absorbed.

Route of Elimination

HBIG is eliminated from the body primarily in the urine. It is also eliminated through the feces and sweat.

Dosage

The dose of HBIG is determined based on the person’s age, weight, and HBV risk factors, and is usually expressed as a milligram of HBIG per kilogram of body weight (mg/kg). For immunization, a single 0.06 mL/kg must be administered as soon as possible after exposure.

Administration

HBIG is usually administered as an intramuscular injection into the deltoid muscle or subcutaneously into the abdomen or thigh.

Side Effect

Side effects are rare with HBIG but may include pain, redness, swelling, and bruising at the injection site. Allergic reactions, rash, headache, and nausea have also been reported.

Toxicity

HBIG is generally considered non-toxic. It is a medication derived from healthy human plasma and is highly purified, so it has a low risk of causing toxic reactions.

Precaution

HBIG should be used with caution in people with a history of allergic reactions and in those with immune deficiency. It should also be used with caution in pregnant and breastfeeding women.

Interaction

HBIG may interact with other medications, such as those given to treat hepatitis B infection. It should not be used at the same time as other vaccines, such as the hepatitis A vaccine or the influenza vaccine.

Disease Interaction

HBIG should not be used in people with an active hepatitis B infection or in those who are allergic to any of its components. It should also not be used in people with autoimmune diseases or HIV.

Drug Interaction

HBIG has no known drug interactions. However, it should not be used at the same time as other vaccines, such as the hepatitis A vaccine or the influenza vaccine.

Food Interactions

HBIG has no known food interactions.

Pregnancy Use

HBIG may be used during pregnancy when the potential benefit outweighs the potential risk. It should be used with caution in pregnant and breastfeeding women.

Lactation Use

HBIG is should be used with caution in breastfeeding women. It is unknown whether it is safe to use during breastfeeding.

Acute Overdose

An acute overdose of HBIG is unlikely to occur as it is usually given as a single dose. If it is given in excessive amounts, however, it may lead to redness and swelling at the injection site.

Contraindication

HBIG should not be used in people with an active hepatitis B infection or in those who are allergic to any of its components. It should also not be used in people with autoimmune diseases or HIV.