Introduction
Gatinox Tablet 400 mg is an antibiotic used for treating certain bacterial infections. It belongs to the class of drugs known as quinolone antibiotics and it works by killing certain types of bacteria.
Uses
Gatifoxacin is used to treat various bacterial infections, such as sinusitis, bronchitis, pneumonia, and others. It is also used to treat skin, ear, and urinary tract infections.
| Brand Name | Gatinox |
|---|---|
| Type | Tablet |
| Weight | 400 mg |
| Generic | Gatifloxacin |
| Manufacturer | Eskayef Pharmaceuticals Ltd. |
| Available in | English বাংলা |
Mechanism of Action
Gatinox Tablet 400 mg works by blocking the actions of two enzymes called DNA gyrase and topoisomerase IV. This prevents the bacteria from repairing and replicating its own DNA, which leads to death of the bacteria.
How Long Does it Take to Work?
Gatinox Tablet 400 mg usually starts to work within 24-48 hours. However, the exact amount of time it takes to work depends on the individual and the type of infection being treated.
Absorption
Gatinox Tablet 400 mg is well-absorbed after oral administration, with peak concentrations typically occurring within 1-4 hours.
Route of Elimination
Gatinox Tablet 400 mg is mainly eliminated via the kidneys. Significant amounts of gatifloxacin are also eliminated via the bile.
Dosage
Gatifloxacin 0.3%: The recommended dosage regimen for the treatment of bacterial conjunctivitis is:- Days 1 and 2: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times daily.
- Days 3 through 7: Instill one drop up to 4 times daily while awake.
- Day 1: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times.
- Days 2 through 7: Instill one drop two to four times daily in the affected eye(s) while awake.
The recommended adult dosage of gatifloxacin is 200-400 mg taken once daily or 400-800 mg twice daily. For pediatric use, the dosage is 10 mg/kg/day taken as a single dose or divided into two doses.
Administration
Gatinox Tablet 400 mg should be taken orally and should be taken with or without food. It should not be taken with antacids containing magnesium or aluminum, as they may decrease the absorption of gatifloxacin.
Side Effects
Common side effects of gatifloxacin include nausea, vomiting, diarrhea, dizziness, headache, and rash. Rare but serious side effects may include tendon rupture, arrhythmias, and liver problems.
Toxicity
Gatinox Tablet 400 mg is generally well-tolerated when taken as directed. Overdose of gatifloxacin may cause nausea, vomiting, and/or diarrhea. In cases of severe overdose, the following symptoms may occur: confusion, delirium, seizures, altered heart rate, and coma.
Precaution
Gatinox Tablet 400 mg should be used with caution in patients with kidney or liver disease, or in patients who are taking other medications that may interact with gatifloxacin.
Interaction
Gatinox Tablet 400 mg may interact with certain antibiotics (e.g., erythromycin), antacids containing magnesium or aluminum, and the anticoagulant warfarin. Patients should consult their healthcare provider before taking any other medications while taking gatifloxacin.
Disease Interactions
Gatinox Tablet 400 mg should not be used in patients with known or suspected myasthenia gravis, as serious adverse reactions can occur. Additionally, gatifloxacin is not recommended for use in patients with a known hypersensitivity to quinolone antibiotics.
Drug Interactions
Gatinox Tablet 400 mg may interact with other medications, including antibiotics (e.g., erythromycin), antacids containing magnesium or aluminum, and the anticoagulant warfarin. Patients should consult their healthcare provider before taking any other medications while taking gatifloxacin.
Food Interactions
Gatinox Tablet 400 mg may interact with certain foods, including dairy products, calcium-fortified juices, and iron-fortified foods or supplements. Patients should talk to their healthcare provider before taking gatifloxacin with these types of foods.
Pregnancy Use
Gatinox Tablet 400 mg should not be used during pregnancy, as it can cause harm to the developing fetus. Women who are pregnant or plan to become pregnant should consult their healthcare provider before taking gatifloxacin.
Lactation Use
Gatinox Tablet 400 mg is not recommended for use during lactation, as it can be passed to the infant through breast milk. Women who are breastfeeding or plan to breastfeed should consult their healthcare provider before taking gatifloxacin.
Acute Overdose
In cases of acute overdose, symptoms may include nausea, vomiting, confusion, delirium, seizures, altered heart rate, and coma. If an overdose is suspected, patients should seek immediate medical attention.
Contraindication
Gatinox Tablet 400 mg should not be used in patients with known or suspected myasthenia gravis, as serious adverse reactions can occur. Additionally, gatifloxacin is not recommended for use in patients with a known hypersensitivity to quinolone antibiotics.
Use Directions
Gatinox Tablet 400 mg should be taken orally as directed by the healthcare provider. It should be taken with or without food, at least one hour before or two hours after meals. The missed dose should be taken as soon as possible unless it is almost time for the next dose, in which case the missed dose should be skipped.
Storage Conditions
Gatinox Tablet 400 mg should be stored at room temperature, away from moisture and heat. It should be kept out of reach of children and pets, and should not be shared with others.
Volume of Distribution
Gatinox Tablet 400 mg has a volume of distribution of approximately 0.8 L/kg.
Half Life
Gatinox Tablet 400 mg has an elimination half-life of approximately 4-5 hours.
Clearance
Gatinox Tablet 400 mg has an oral clearance of approximately 0.1 L/hr/kg.
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