Fusate Cream

Fusate Cream 2%

Sodium fusidate, or sodium fusidate, is an antibiotic of the fusidic acid class used to treat certain bacterial infections. It is used in the treatment of skin infections, serious streptococcal and staphylococcal infections, and systemic infections. It is also used to treat sequelae of diphtheria infections, chronic bronchitis, and other respiratory infections.

Uses

Sodium fusidate is used to treat infections caused by staphylococci (Staphylococcus aureus, Streptococcus pneumoniae), Haemophilus influenzae, Moraxella catarrhalis, and certain other bacteria.

Brand Name	Fusate
Type	Cream
Weight	2%
Generic	Sodium Fusidate
Manufacturer	Amulet Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Sodium fusidate exerts its bactericidal action by inhibiting the bacterial protein synthesis. It binds to the bacterial 23S ribosomal RNA of the 50S subunit and inhibits peptide bond formation.

How long does it take to work?

Sodium fusidate typically begins to work within 1-2 days of taking it. Improvement in symptoms such as itching, redness, swelling and pain should be noticed during the first few days of treatment.

Absorption

Sodium fusidate is completely absorbed by the gastrointestinal tract after oral administration.

Route of Elimination

Sodium fusidate is eliminated mainly through the kidneys.

Dosage

The recommended adult dosage of sodium fusidate for infections caused by susceptible organisms is 500 mg every 12 hours. The dose may be increased to 1000 mg every 12 hours if necessary. For skin infections, the recommended dosage is 250 mg twice daily for seven days.

Administration

Sodium fusidate is usually taken orally, though it can also be given intravenously in some cases. It should be taken with food to lessen gastrointestinal discomfort.

Side Effect

Common side effects of sodium fusidate include nausea, vomiting, abdominal pain, dizziness, headache, itching, rash, metallic taste, and diarrhea. Other more serious side effects include allergic reactions, tendon inflammation, and renal dysfunction.

Toxicity

No toxicity studies have been conducted with sodium fusidate. It is thought to be safe in therapeutic doses, but toxicities such as vomiting, abdominal pain, and dizziness may occur with higher doses.

Precaution

Patients taking sodium fusidate should be regularly monitored for signs of adverse reactions. The antibiotic should be used with caution in patients with hepatic or renal disorders and those taking other medications that may interact with sodium fusidate.

Interaction

Sodium fusidate may interact with other medications, including certain antibiotics, anticoagulants, and anticonvulsants. It is also important to inform a doctor of any other medications being taken before starting treatment with sodium fusidate.

Disease Interaction

Sodium fusidate may not be suitable for all patients. Patients should inform their doctor of any other medical conditions they have before taking sodium fusidate, such as hepatic or renal disease, as these may interact with the antibiotic.

Drug Interaction

Sodium fusidate can interact with other medications, including certain antibiotics, anticoagulants, and anticonvulsants. It is important to notify a doctor of any other medications a patient may be taking before starting treatment with sodium fusidate.

Food Interactions

There are no known food interactions with sodium fusidate.

Pregnancy Use

Sodium fusidate should be used with caution by pregnant women as it may cause fetal harm. It should not be used if it is known that the baby will have an allergic reaction to sodium fusidate.

Lactation Use

Sodium fusidate is excreted in breast milk and may cause adverse reactions in nursing infants, including diarrhea, loose stools, vomiting, and rash. Mothers should avoid using this medication while breastfeeding.

Acute Overdose

Patients who ingest more than the recommended dose should seek medical attention immediately. Symptoms of an acute overdose may include nausea, vomiting, abdominal pain, dizziness, and hypotension.

Contraindication

Sodium fusidate should be avoided in patients who are allergic to it, as well as those with liver or kidney impairment.

Use Direction

Sodium fusidate should be taken as directed by a doctor. The usual adult dose of sodium fusidate is 500 mg every 12 hours. For skin infections, the recommended dosage is 250 mg twice daily for seven days.