FreFast Cream

Introduction

Methyl salicylate, menthol, and camphor are combined in topical analgesic preparations for their synergistic effects in relieving pain and discomfort. These compounds are commonly found in ointments, creams, and gels used for musculoskeletal pain, such as back pain, arthritis, and muscle strains. They work by providing localized relief through their counterirritant and analgesic properties.

Uses

This combination is used for:

Relieving minor aches and pains of muscles and joints.
Alleviating pain associated with arthritis, muscle strains, and sprains.
Providing temporary relief from sore muscles and back pain.

It is typically applied to the skin in the affected area to provide symptomatic relief.

Brand Name	FreFast
Type	Cream
Weight	30%+10%+4%
Generic	Methyl Salicylate + Menthol + Camphor
Manufacturer	Pacific Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Methyl salicylate, menthol, and camphor work through different mechanisms:

Methyl salicylate (a form of salicylic acid) acts as a counterirritant, creating a sensation of warmth that helps distract from pain and promotes blood flow to the area.
Menthol provides a cooling sensation that also acts as a counterirritant, helping to relieve pain and discomfort by cooling and soothing the skin.
Camphor has a cooling effect and may also have analgesic and anti-inflammatory properties that contribute to pain relief.

Together, these ingredients produce a combined effect of warming, cooling, and counterirritant sensations to alleviate pain.

How Long Does It Take to Work?

The effects of topical applications containing methyl salicylate, menthol, and camphor are typically felt within 30 minutes to 1 hour of application. The duration of pain relief can last for several hours, depending on the specific product formulation and individual response.

Absorption

These compounds are absorbed through the skin, but their systemic absorption is minimal due to their topical use. The primary effect is localized to the area where the product is applied. Proper application and massage into the skin can enhance absorption and effectiveness.

Route of Elimination

Minimal systemic absorption means that these compounds are primarily eliminated through local metabolism and are not significantly excreted via the urine or feces. The main route of elimination for any absorbed amounts is through metabolic processes in the liver and kidneys.

Dosage

Cream:
Adults and Children 2 years of age and older: Apply generously to the painful area and gently massage until the cream disappears. Apply to affected area not more than 3 to 4 times daily.If condition worsens,or if symptoms persist for more than 7 days or clear-up and occur again within a few days,discontinue use of this product and consult a doctor.

Children below 2 years of age: Sufficient data is not available for use of this product in children below 2 years of age.

Nasal Inhaler Stick:
Adults and children over 12 years: Used by inserting the inhaler into each nostril, holding the other nostril closed and inhaling deeply. It can be used as frequently as needed.

The dosage for topical products is typically determined by the specific product formulation. Common recommendations include:

Apply a thin layer to the affected area 3 to 4 times daily, or as directed by the product label or a healthcare provider.

Dosage may vary based on product concentration and individual needs. Avoid excessive use to prevent irritation.

Administration

Administer the product topically:

Clean and dry the affected area before application.
Apply a thin layer of the product and gently massage into the skin.
Wash hands thoroughly after application, unless the hands are the treated area.

Follow the specific instructions provided on the product label or by a healthcare professional.

Side Effects

Possible side effects include:

Skin irritation, redness, or rash at the application site.
Burning or stinging sensations.

If side effects are severe or persistent, discontinue use and consult a healthcare provider.

Toxicity

Topical applications are generally safe when used as directed. However, excessive or improper use may lead to:

Severe skin irritation or allergic reactions.
Systemic toxicity if large amounts are absorbed through broken skin or mucous membranes.

Seek medical attention if symptoms of toxicity or severe reactions occur.

Precautions

Precautions include:

Avoid applying to broken or irritated skin.
Keep away from eyes, mucous membranes, and sensitive areas.
Do not use on large areas of the body or for extended periods without consulting a healthcare provider.

Follow usage instructions carefully and consult a healthcare provider if you have underlying skin conditions or are pregnant.

Interaction

Interactions with other medications are minimal due to the topical application. However, avoid concurrent use with other topical products containing similar active ingredients to prevent potential overuse or irritation.

Disease Interaction

Use with caution in individuals with:

Skin conditions such as eczema or psoriasis, which may be aggravated by topical applications.
Allergies or sensitivities to the active ingredients.

Consult a healthcare provider if you have any pre-existing conditions that may affect the use of topical analgesics.

Drug Interaction

Drug interactions are unlikely due to the topical nature of the product. However, always inform healthcare providers of all medications and topical products used to avoid potential interactions or adverse effects.

Food Interactions

There are no significant food interactions with topical use of these compounds. The product can be used without regard to food intake.

Pregnancy Use

Topical use during pregnancy should be approached with caution. Consult a healthcare provider before using products containing methyl salicylate, menthol, and camphor during pregnancy. It is important to evaluate the risks and benefits based on individual circumstances.

Lactation Use

Consult a healthcare provider before using this product while breastfeeding. While systemic absorption is minimal, it is important to ensure that the product is safe for use around the chest area if breastfeeding.

Acute Overdose

Acute overdose from topical use is rare but could occur if large amounts are applied or if the product is ingested. Symptoms of overdose may include severe skin irritation or systemic symptoms if significant absorption occurs. Seek medical attention if an overdose is suspected.

Contraindication

Contraindications include:

Known hypersensitivity or allergic reactions to methyl salicylate, menthol, or camphor.
Application to broken or inflamed skin.

Avoid use in these situations to prevent adverse reactions.

Use Direction

For effective use:

Apply to clean, dry skin in the affected area 3 to 4 times daily.
Do not apply to broken or irritated skin.
Wash hands after application unless they are the treated area.

Follow all product-specific instructions and consult a healthcare provider if uncertain about usage.

Storage Conditions

Store the product in a cool, dry place at room temperature (15-30°C or 59-86°F). Keep the container tightly closed and out of reach of children. Avoid exposure to moisture and direct sunlight.

Volume of Distribution

The volume of distribution is not typically measured for topical analgesics. The active ingredients mainly exert their effects locally at the site of application.

Half Life

The half-life of the active ingredients is not specifically measured for topical products. The effects are localized, and the active ingredients are metabolized and cleared through local processes and minimal systemic absorption.

Clearance

Clearance occurs mainly through local metabolism and minimal systemic absorption. Excess amounts of the compounds are processed in the liver and kidneys, but significant systemic clearance is rare with topical use.

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