Flamic Tablet

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Flamic Tablet 250 mg is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea.

For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

• Mild pain
• Primary Dysmenorrhoea
• Gastrointestinal cramps
• Moderate Pain

Flamic Tablet 250 mg, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.

Flamic Tablet 250 mg binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.

Flamic Tablet 250 mg is rapidly absorbed after oral administration.

• 1.06 L/kg [Normal Healthy Adults (18-45 yr)]

90%

The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Flamic Tablet 250 mg, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.

2 hours

• Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]

Oral, rat LD₅₀: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.

• Avoid alcohol.
• Take with food.