Ficlox Powder for Suspension

Introduction

Cloxacillin sodium is a semisynthetic antibiotic, belonging to a class of antibiotics known as penicillin derivatives. It is used to treat a variety of bacterial infections and is considered to be a safer alternative to other antibiotics.

Uses

Cloxacillin sodium is used to treat a variety of bacterial infections, including bacterial pneumonia, skin or soft tissue infections, endocarditis, urinary tract infections, and certain sexually transmitted diseases. It may also be used to treat certain bone and joint infections.

Brand Name	Ficlox
Type	Powder for Suspension
Weight	125 mg/5 ml
Generic	Cloxacillin Sodium
Manufacturer	Sanofi Bangladesh Ltd.
Available in	English বাংলা

Mechanism of Action

Cloxacillin sodium works by inhibiting the growth of bacteria. It works specifically by preventing the formation of the cell wall of the bacteria, which disrupts the structure of the cell and ultimately leads to cell death.

How Long Does It Take to Work?

It typically takes 1 to 2 weeks for cloxacillin sodium to take effect. However, some individuals may feel the effects of this medication sooner than others.

Absorption

Cloxacillin sodium is rapidly and completely absorbed orally. After oral administration, peak plasma concentration is achieved within 1 hour.

Route of Elimination

Cloxacillin sodium is primarily eliminated by the kidneys. Up to 60% of a dose is excreted unchanged in the urine, while the remainder is metabolized by the liver and eliminated in the bile.

Dosage

প্রাপ্তবয়স্কদের প্রচলিত মাত্রা-
খাওয়ার জন্য: ৫০০ মিগ্রা দিনে চার বার আহারের আধা থেকে এক ঘন্টা আগে।
ইনজেকশন হিসেবে:

• মাংসপেশীতে ইনজেকশন হিসেবে: ২৫০ মিগ্রা চার থেকে ছয় ঘন্টা পর পর।
• শিরাপথে ইনজেকশন হিসেবে: ৫০০ মিগ্রা চার থেকে ছয় ঘন্টা পর পর। প্রয়োজনবোধে উপরোল্লিখিত মাত্রাকে দ্বিগুণ করা যেতে পারে।
• প্লুরাল কেভিটিতে ইনজেকশন হিসেবে: ৫০০ মিগ্রা দিনে এক বার। 
• জয়েন্ট কেভিটিতে ইনজেকশন হিসেবে: ৫০০ মিগ্রা দিনে এক বার।

শিশুদের প্রচলিত মাত্রা-
খাওয়ার জন্য: ২ থেকে ১০ বৎসর পর্যন্ত- প্রাপ্তবয়স্ক মাত্রার অর্ধেক। ২ বৎসরের নীচে- প্রাপ্তবয়স্ক মাত্রার এক-চতুর্থাংশ।
ইনজেকশন হিসেবে:

• মাংসপেশীতে ইনজেকশন হিসেবে: ২৫০ মিগ্রা এর সাথে ১.৫ মিলি কিংবা ৫০০ মিগ্রা এর সাথে ২ মিলি ওয়াটার ফর ইনজেকশন বিপি মিশিয়ে দ্রবীভূত করতে হবে।
• শিরাপথে ইনজকেশন হিসাবে: ৫০০ মিগ্রা এর সাথে ৫-১০ মিলি ওয়াটার ফর ইনজকেশন বিপি মিশিয়ে দ্রবীভূত করতে হবে। এরপর এই দ্রবণকে তিন থেকে চার মিনিট ধরে ধীরে ধীরে শরীরে প্রয়োগ করতে হবে। ক্লক্সাসিলিন ইনজকেশনকে ইনফিউশন উপযোগী যে কোন তরলে মিশিয়ে দেয়া যায় অথবা যথাযথ ভাবে হালকা করে ড্রপি টউিবে তিন থেকে চার মিনিট ধরে ধীরে ধীরে প্রয়োগ করা যায়।
• প্লুরাল কেভেটিতে ইনজেকশন হিসেবে: ৫০০ মিগ্রা এর সাথে ৫ থেকে ১০ মিলি ওয়াটার ফর ইনজকেশন বিপি মিশিয়ে দ্রবীভূত করে প্রয়োগ করতে হবে।
• জয়েন্টে কেভেটিতে ইনজেকশন হিসেবে: ৫০০ মিগ্রা এর সাথে অনধকি ৫ মিলি ওয়াটার ফর ইনজকেশন বিপি অথবা ০.৫% লিগনোকেইন হাইড্রোক্লোরাইড দ্রবণ মিশিয়ে দ্রবীভূত করে প্রয়োগ করতে হবে।

The recommended adult dosage of cloxacillin sodium is 250-500 mg four times daily, with a maximum daily dose of 4 g. For children, the dosage will depend on their body weight and should be determined by a physician.

Administration

Cloxacillin sodium should be taken orally with or without food. Swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets.

Side Effect

Common side effects of cloxacillin sodium include stomach discomfort, nausea, vomiting, and diarrhea. Other more serious side effects include rash, itching, and fever. If any of these side effects occur, contact your doctor immediately.

Toxicity

Cloxacillin sodium is generally considered non-toxic and is safe to use in the recommended doses. Overdose of this medication is unlikely to cause life-threatening toxicity; however, it may cause certain side effects such as increased urination, diarrhea, and vomiting.

Precaution

Before taking cloxacillin sodium, you should tell your doctor if you have any allergies or if you use any other medications, including antibiotics or other drugs used to treat bacterial infections. You should also tell your doctor if you have any other medical conditions, such as kidney or liver disease, as these can affect the way in which cloxacillin sodium is metabolized and eliminated from the body.

Interaction

Certain drug interactions may occur when taking cloxacillin sodium. It is important to tell your doctor about any medications you are taking, as well as any herbal supplements or over-the-counter drugs. It is also important to avoid drinking alcohol while taking this medication, as alcohol can decrease the effectiveness of cloxacillin sodium.

Disease Interaction

Patients with pneumonia or endocarditis may need to adjust their dosage of cloxacillin sodium. Cloxacillin sodium should be avoided in patients with a history of serious allergies to penicillin or cephalosporin drugs.

Drug Interaction

Cloxacillin sodium may interact with other drugs. Tell your doctor about any other medications, including antibiotics, anticoagulants, antifungals, or anti-seizure medications that you currently take.

Food Interactions

Certain foods may interact with cloxacillin sodium and should be avoided. Foods high in dietary calcium, such as dairy products, may reduce the absorption of cloxacillin sodium. Foods with high levels of fiber, such as bran, may also interfere with the absorption of this medication.

Pregnancy use

Cloxacillin sodium is not recommended for use during pregnancy. If you are pregnant, it is important to tell your doctor so that they can prescribe an alternate medication.

Lactation use

Cloxacillin sodium is not recommended for use during lactation. It is important to tell your doctor if you are breastfeeding before taking this medication.

Acute Overdose

An acute overdose of cloxacillin sodium is unlikely to cause serious toxicity if the recommended dosage is not exceeded. If an overdose is suspected, contact your local poison control center immediately.

Contraindication

Cloxacillin sodium is contraindicated in patients with a history of hypersensitivity to penicillin or cephalosporin drugs.

Use Direction

Cloxacillin sodium should be taken as directed by your doctor. This medication should be taken orally with or without food. It is important to take this medication as prescribed in order to ensure efficacy and to minimize potential side effects.

Storage Condition

Cloxacillin sodium should be stored at room temperature and protected from light and moisture. Keep the medication in its original container with the lid tightly closed when not in use.

Volume of Distribution

The volume of distribution of cloxacillin sodium is approximately 8.7 L/kg.

Half Life

The half-life of cloxacillin sodium is approximately 2-3 hours.

Clearance

The total body clearance of this medication is approximately 8 L/h/kg.

See in details version Ficlox Powder for Suspension 125 mg/5 ml also Ficlox Powder for Suspension 125 mg/5 ml in bangla

Some Frequently Asked Questions About Ficlox Powder for Suspension 125 mg/5 ml

1. What is Ficlox Powder for Suspension 125 mg/5 ml?

Ficlox Powder for Suspension 125 mg/5 ml is a beta-lactam antibiotic used to treat bacterial infections, especially those caused by penicillinase-producing staphylococci.

2. What type of infections does Cloxacillin treat?

It is used to treat:

• Skin and soft tissue infections
• Respiratory tract infections
• Bone and joint infections
• Endocarditis
• Septicemia

3. How does Cloxacillin work?

It inhibits bacterial cell wall synthesis, leading to bacterial cell death.

4. Is Cloxacillin effective against MRSA?

No, MRSA (Methicillin-resistant Staphylococcus aureus) is resistant to Cloxacillin.

5. How should I take Cloxacillin?

It is best taken on an empty stomach (1 hour before or 2 hours after a meal) with a full glass of water.

6. What is the usual dosage for adults?

Typically, 250-500 mg every 6 hours, but dosage may vary depending on the infection and doctor's advice.

7. Can children take Cloxacillin?

Yes, but the dosage should be adjusted based on weight and prescribed by a doctor.

8. Can I take Cloxacillin with food?

No, food may reduce absorption. Take it on an empty stomach.

9. How long should I take Cloxacillin?

Complete the full course as prescribed by your doctor, usually 7-14 days, depending on the infection.

10. What happens if I miss a dose?

Take it as soon as you remember, but skip it if it’s almost time for the next dose. Do not double the dose.

11. Can I stop taking Cloxacillin if I feel better?

No, stopping early can cause the infection to return or lead to antibiotic resistance.

12. What are the common side effects of Cloxacillin?

Common side effects include:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Skin rash

13. Can Cloxacillin cause allergic reactions?

Yes, symptoms may include rash, itching, swelling, or difficulty breathing. Seek immediate medical help if severe.

14. Is Cloxacillin safe for pregnant women?

It is generally considered safe, but consult your doctor before use.

15. Can breastfeeding mothers take Cloxacillin?

Yes, but small amounts may pass into breast milk. Consult a doctor before use.

16. Does Cloxacillin interact with other medications?

Yes, it may interact with:

• Oral contraceptives (may reduce effectiveness)
• Probenecid (may increase Cloxacillin levels)
• Blood thinners like Warfarin

17. Can Cloxacillin cause diarrhea?

Yes, it can disturb gut bacteria. If severe or bloody diarrhea occurs, seek medical help.

18. Does Cloxacillin affect kidney function?

It is generally safe, but patients with kidney disease should take it with caution.

19. Can Cloxacillin cause liver problems?

Rarely, it may cause liver enzyme elevation. Monitor liver function if using long-term.

20. What should I do if I overdose on Cloxacillin?

Seek medical attention immediately. Symptoms may include severe nausea, vomiting, or convulsions.

21. Can I drink alcohol while taking Cloxacillin?

Alcohol may increase side effects like stomach upset, so it is best to avoid it.

22. Can I take Cloxacillin with painkillers?

Yes, it can be taken with paracetamol or ibuprofen if needed.

23. Does Cloxacillin cause yeast infections?

Yes, prolonged use may lead to fungal overgrowth, causing yeast infections.

24. Can Cloxacillin be used to treat a cold or flu?

No, it only works against bacterial infections, not viral infections.

25. Is Cloxacillin available over the counter?

No, it requires a prescription.

26. How should Cloxacillin be stored?

Store at room temperature (below 25°C) away from moisture and sunlight.

27. Can Cloxacillin cause dizziness?

It is not common, but some people may experience dizziness.

28. Does Cloxacillin affect blood sugar levels?

It is unlikely, but diabetics should monitor blood sugar levels.

29. Can Cloxacillin be used for urinary tract infections (UTIs)?

It is not the first choice for UTIs; other antibiotics are more effective.

30. Can Cloxacillin treat pneumonia?

Yes, if caused by susceptible bacteria, but other antibiotics are often preferred.

31. Does Cloxacillin affect birth control pills?

Yes, it may reduce their effectiveness. Use additional contraception.

32. Can I take Cloxacillin if I have a penicillin allergy?

No, it is a penicillin-type antibiotic and can cause allergic reactions.

33. Can Cloxacillin cause joint pain?

Rarely, some patients may experience joint pain.

34. Can I take Cloxacillin before surgery?

Only if prescribed by a doctor to prevent bacterial infections.

35. Can Cloxacillin be used for acne?

It is not commonly used for acne; other antibiotics like doxycycline are preferred.

36. Can I take Cloxacillin for an ear infection?

Yes, if the infection is caused by susceptible bacteria.

37. How quickly does Cloxacillin start working?

Improvement is usually seen within 24-48 hours.

38. Can Cloxacillin cause a bad taste in the mouth?

Yes, some people may experience an unusual taste.

39. Does Cloxacillin cause sun sensitivity?

No, but it is still good to use sun protection.

40. Can I take probiotics with Cloxacillin?

Yes, probiotics may help prevent diarrhea.

41. Can Cloxacillin be given through an IV?

Yes, it is available in both oral and IV forms.

42. Is Cloxacillin used in dental infections?

Yes, it may be used for dental abscesses.

43. Can Cloxacillin be taken for long-term infections?

Yes, but long-term use should be monitored by a doctor.

44. Does Cloxacillin work against E. coli?

No, it is not effective against E. coli.

45. Can Cloxacillin be used for animal infections?

Yes, but veterinary dosage differs.

46. Can I open Cloxacillin capsules?

It is best to swallow whole unless advised otherwise.

47. Can I drive while taking Cloxacillin?

Yes, unless you experience dizziness.

48. Does Cloxacillin expire?

Yes, do not use expired medication.

49. Does Cloxacillin affect sleep?

No, but some people may experience mild restlessness.