Ezair Tablet

Introduction

Montelukast sodium is a leukotriene receptor antagonist (LTRA) which has anti-inflammatory properties and is used to prevent and manage asthma and allergic rhinitis. Montelukast sodium is marketed under brand names such as Singulair, Chiklabet, Lukasm, Montegen, and Montene.

Uses for

Montelukast sodium is used to treat symptoms of asthma and allergic rhinitis (nasal allergies). It helps relieve symptoms such as: coughing, wheezing, shortness of breath, chest tightness, and runny or itchy nose. This drug is also used to prevent exertional asthma (asthma triggered by physical activity).

Mechanism of Action

Montelukast sodium is a leukotriene receptor antagonist (LTRA). It works by blocking the action of leukotrienes, which are substances in the body that cause inflammation (swelling and irritation) in the airways. By blocking leukotrienes, Montelukast sodium helps reduce the inflammation associated with asthma and allergic rhinitis symptoms.

How Long Does It Take to Work?

Montelukast sodium begins to work within 1 hour of ingestion. It is most effective when taken regularly each day at the same time.

Absorption

Montelukast sodium is rapidly and completely absorbed from the gastrointestinal tract, with peak concentrations occurring within 2-4 hours. It is highly bound to the plasma proteins and distributed to the lungs, intestines and other organs.

Route of Elimination

Montelukast sodium is metabolized by the liver and excreted mainly by the kidneys as metabolites.

Dosage

Montelukast sodium is available in multiple forms and strengths. The dosage for adults and adolescents is 10 mg once daily, while the dosage for children ages 6 to 14 is 5 mg once daily. The dosage for children ages 2 to 5 is 4 mg once daily.

Administration

Montelukast sodium can be taken with or without food. It should be taken at the same time each day.

Side Effect

Commonly reported side effects of Montelukast sodium include fever, headaches, abdominal pain, diarrhea, nausea, cough, and dizziness. Less common side effects may include rash, joint pain, increased appetite, and weight gain.

Toxicity

Montelukast sodium is well tolerated, and no serious toxicity has been reported. However, overdosage should be avoided as it can cause mild to moderate nausea and vomiting.

Precaution

Patients taking Montelukast sodium should be monitored for signs of allergic reactions and possible toxicity. It may also interact with certain medications, including warfarin, cyclosporine, and theophylline. Patients should not take Montelukast sodium with grapefruit juice or grapefruit products as they may reduce the effectiveness of the medication and lead to potential toxicity.

Interaction

Montelukast sodium may interact with certain medications, including warfarin, cyclosporine, and theophylline. Patients should not take Montelukast sodium with grapefruit juice or grapefruit products as they may reduce the effectiveness of the medication and lead to potential toxicity.

Disease Interaction

Montelukast sodium may interact with certain diseases, including certain liver diseases (e.g., cirrhosis) and kidney diseases. Patients with these conditions should consult a healthcare provider before taking Montelukast sodium.

Drug Interaction

Drugs that may interact with Montelukast sodium include warfarin, cyclosporine, and theophylline. Patients should let their healthcare provider know of any medications they are taking before taking Montelukast sodium, as these medications may interact with the drug.

Food Interactions

Montelukast sodium may interact with certain foods or beverages. Patients should avoid grapefruit juice or grapefruit products while taking Montelukast sodium as these products may reduce the effectiveness of the medication and lead to potential toxicity.

Pregnancy Use

Montelukast sodium is not recommended for use in pregnant women. Studies on animals have shown that it may cause harm to the fetus. Therefore, pregnant women should consult a healthcare provider before taking this medication.

Lactation Use

Montelukast sodium is not recommended for use in breastfeeding women, as it is not known whether it is safe in this population. The safety and efficacy in breastfeeding infants is also unknown. Therefore, breastfeeding women should consult a healthcare provider before taking this medication.