Ecolet Cream

Introduction

Econazole nitrate is an antifungal imidazole derivative drug used to treat a variety of fungal infections. It is a topical medication that is applied directly to the affected area and is available in a number of different formulations, including creams, ointments, lotions, powders, and sprays.

Uses

Econazole nitrate is most commonly used to treat skin infections and superficial fungal infections of the feet, hands, and nails. It is also used to treat athlete’s foot, jock itch, ringworm, and fungal vaginitis.

Brand Name	Ecolet
Type	Cream
Weight	1%
Generic	Econazole Nitrate
Manufacturer	Amulet Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Econazole nitrate blocks the action of the enzyme lanosterol 14α-demethylase, which is involved in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting this enzyme, it prevents the growth and reproduction of fungal cells, ultimately resulting in fungal death.

How Long Does It Take to Work?

Generally, skin conditions treated with econazole nitrate should show improvement in 1 to 4 weeks. However, since the rate of improvement varies depending on the severity of the infection and individual healing responses, some people may experience results much sooner or take longer to notice an improvement.

Absorption

Econazole nitrate is readily absorbed by the skin. The rate of absorption is dependent on the formulation used and the specific areas of application.

Route of Elimination

Econazole nitrate is not known to be eliminated through any major route, although it may be eliminated in small quantities through the kidneys.

Dosage

Econazole vaginal tablet: One tablet should be inserted deep into the vagina at bed time for three consecutive nights. Treatment should be continued even if menstruation occurs. Although a three night course of treatment is often sufficient longer courses are advisable for women with recurrent vaginal infections.

Econazole 30 gm cream: The supplied applicator should be filled with econazole cream and then inserted deep into the vagina at bedtime once or twice daily.

Econazole 10 gm cream: Apply sparingly to the affected area once or twice daily until improvement occurs.

Sufficient Econazole cream should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis. Early relief of symptoms is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, candidal infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.

The recommended amount of econazole nitrate to use depends on the specific product being used. Generally, it is applied once or twice a day. Cream and ointment can be applied to skin 2-3 times a day. Powder product may be applied once a day. For other formulations, refer to the product's label instructions.

Administration

Econazole nitrate should be applied directly to the affected area. It can be applied with a clean cotton swab, applicator, or fingertips. Wash hands after applying the medication. Do not cover the treated area unless directed to do so by a healthcare professional.

Side Effect

Side effects of econazole nitrate are typically mild and include skin irritation, burning, itching, redness, or dryness. Severe allergic reactions are rare, but can occur. Seek medical attention immediately in case of serious side effects.

Toxicity

Econazole nitrate is generally well-tolerated when used as directed. However, certain individuals may be more sensitive to the drug and therefore may be at increased risk of experiencing a toxic reaction.

Precaution

Econazole nitrate should not be used on open wounds or mucous membranes. Do not use the product near the eyes, nose, or mouth. Do not apply to the scalp, face, or other areas where it is not specifically directed to do so. Wash hands thoroughly after application. If irritation or discomfort occurs, discontinue use and seek medical advice.

Interaction

Econazole nitrate may interact with other medications, herbal products, vitamin supplements, and over-the-counter drugs. Therefore, it is important to talk to a healthcare professional before using econazole nitrate in combination with any other medications or products.

Disease Interaction

Econazole nitrate should not be used in patients with known allergies to imidazole antifungal agents. There are no known disease interactions with econazole nitrate. It is important to talk to a healthcare professional before using econazole nitrate if you have any other known medical conditions.

Drug Interaction

Econazole nitrate may interact with other medications, including antifungal or antibiotic drugs, or other topical preparations. It is important to talk to a healthcare professional before combining econazole nitrate with any other medications.

Food Interactions

There are no known food interactions with econazole nitrate. However, it is important to talk to a healthcare professional before consuming alcohol or any kind of beverages while using econazole nitrate.

Pregnancy Use

Econazole nitrate is not recommended for use in pregnant women unless the potential benefit justifies the potential risk to the unborn baby.

Lactation Use

Econazole nitrate is not recommended for use in nursing mothers unless the potential benefit justifies the potential risk to the baby.

Acute Overdose

In case of acute overdose, seek immediate medical attention. The symptoms of acute econazole nitrate overdose include difficulty breathing, dizziness, skin rash, sore throat, and nausea.

Contraindication

Econazole nitrate should not be used in patients who have known allergies to imidazole antifungal agents. You should also talk to a healthcare professional if you are pregnant, breastfeeding, or using any other medications before you start using econazole nitrate.

Use Direction

Econazole nitrate should be applied directly to the affected area according to the specific product’s instructions. Wash hands thoroughly after application. Do not cover the treated area unless directed to do so by a healthcare professional.

Storage Condition

Econazole nitrate should be stored at room temperature, away from direct sunlight, and out of reach of children and pets. Keep product away from heat and moisture. Do not freeze.