Doxair Syrup

Introduction

Doxair Syrup 100 mg/5 ml is a prescription bronchodilator medication used to treat lung diseases such as chronic obstructive pulmonary disease (COPD). It is sometimes referred to as a 'rescue' or 'reliever' medication because it helps to quickly open the airways for people suffering from sudden asthma attacks. Doxair Syrup 100 mg/5 ml works by binding to receptors in the lungs, preventing them from tightening, resulting in difficulty breathing.

Uses

Doxair Syrup 100 mg/5 ml is used to prevent and treat bronchospasms (inflammation of the airways causing difficulty breathing) in people with COPD, asthma and other airway diseases. It may be used alone or combined with other drugs. It can also be used to treat exercise-induced bronchoconstriction.

Brand Name	Doxair
Type	Syrup
Weight	100 mg/5 ml
Generic	Doxophylline
Manufacturer	Jenphar Bangladesh Ltd.
Available in	English বাংলা

Mechanism of Action

Doxair Syrup 100 mg/5 ml works by binding to and blocking receptors in the lungs, known as muscarinic receptors. This prevents the lungs from tightening and makes breathing easier. Anticholinergics like Doxair Syrup 100 mg/5 ml act by interfering with the release of acetylcholine, a neurotransmitter, which is responsible for reducing the size of the airways in the lungs.

How Long Does it Take to Work?

Doxair Syrup 100 mg/5 ml usually takes around 15 minutes to start working. For some people, Doxair Syrup 100 mg/5 ml can start working within 5 minutes. In general, it takes around 30 minutes for Doxair Syrup 100 mg/5 ml to reach peak effectiveness.

Absorption

Doxair Syrup 100 mg/5 ml is readily absorbed from the gastrointestinal tract after oral administration. The absorption of Doxair Syrup 100 mg/5 ml is slightly decreased by food but it still reaches peak plasma concentrations about 3.5 hours after a single dose.

Route of Elimination

Doxair Syrup 100 mg/5 ml is eliminated mainly by the kidneys, primarily through glomerular filtration. The drug is also metabolized in the liver, where it is converted to an active metabolite.

Dosage

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.

Children:

>12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.
6-12 years of age: 6-9 mg/kg body weight two times daily, i.e. if body weight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If required daily dose of Doxophylline is 400 mg then Doxophylline SR tablet to be taken once daily or as prescribed by the physician

Doxair Syrup 100 mg/5 ml dosage is typically based on the patient's age, weight, and condition. The usual starting dose is 2.5 to 5 mg every 6 to 12 hours, but this may be increased or decreased depending on how the patient responds. The maximum daily dose is 40 mg.

Administration

Doxair Syrup 100 mg/5 ml is available in tablet, syrup, and injection forms for oral and parenteral use. It is usually taken orally every 6 to 12 hours, with or without food. It can also be given intravenously or through nebulization for the treatment of acute exacerbations of COPD.

Side Effects

The most common side effects of Doxair Syrup 100 mg/5 ml are headache, nausea, vomiting, stomach pain, dry mouth, difficulty sleeping, anxiety, dizziness, sweating, tremor, and blurred vision. More serious side effects may include rapid heartbeat, chest pain, and confusion.

Toxicity

Doxair Syrup 100 mg/5 ml is generally well tolerated, although an overdose can be serious. Signs of an overdose include seizures, irregular heartbeat, and hallucinations. If someone is suspected of having taken an overdose, they should seek medical attention immediately.

Precautions

Most people can take Doxair Syrup 100 mg/5 ml safely if prescribed by a doctor. However, people with certain medical conditions may need to take special precautions when taking the drug. This includes pregnant or nursing women, people with kidney or liver problems, and those taking certain other medications.

Interactions

Doxair Syrup 100 mg/5 ml may interact with certain other medications, including statins, beta blockers, diuretics, and antacids. It may also interact with certain foods, such as grapefruit juice. People taking Doxair Syrup 100 mg/5 ml should check with their doctor before taking any new medications, including over-the-counter medications or supplements.

Disease Interactions

Doxair Syrup 100 mg/5 ml may be contraindicated for people with certain medical conditions, such as kidney or liver disease, glaucoma, overactive thyroid, and certain heart conditions. It may also cause symptoms to worsen for people with lung diseases, such as emphysema or asthma.

Drug Interactions

Doxair Syrup 100 mg/5 ml may interact with certain medications, including antibiotics, tricyclic antidepressants, beta blockers, diuretics, and digoxin. Other drugs that may interact with Doxair Syrup 100 mg/5 ml include certain cholesterol medications, antacids, and drugs used to treat seizures.

Food Interactions

Grapefruit and grapefruit juice may interact with Doxair Syrup 100 mg/5 ml and should be avoided. Large amounts of caffeine and certain herbs and supplements can also interact with Doxair Syrup 100 mg/5 ml.

Pregnancy Use

Doxair Syrup 100 mg/5 ml should be used with caution during pregnancy, since it has been linked to an increased risk of birth defects. Women who are pregnant or planning to become pregnant should talk to their doctor before taking Doxair Syrup 100 mg/5 ml.

Lactation Use

Doxair Syrup 100 mg/5 ml can pass into breast milk, so it should be used with caution in nursing mothers. Women who are breastfeeding should talk to their doctor before taking Doxair Syrup 100 mg/5 ml.

Acute Overdose

An overdose of Doxair Syrup 100 mg/5 ml can be serious and can cause seizures, irregular heartbeat, confusion, and hallucinations. If someone is suspected of having taken an overdose of Doxair Syrup 100 mg/5 ml, they should seek medical attention immediately.

Contraindication

Doxair Syrup 100 mg/5 ml should not be used in people with certain medical conditions, such as kidney or liver disease, glaucoma, overactive thyroid, and certain heart conditions. It may also cause symptoms to worsen for people with lung diseases, such as emphysema or asthma.

Use Direction

Doxair Syrup 100 mg/5 ml should be taken as prescribed by a doctor. The usual starting dose is 2.5 to 5 mg every 6 to 12 hours, but this may be increased or decreased depending on how the patient responds. Doxair Syrup 100 mg/5 ml should be taken with or without food, but avoiding grapefruit and grapefruit juice. The maximum daily dose is 40 mg.

Storage Condition

Doxair Syrup 100 mg/5 ml should be stored at room temperature, away from heat and light. Do not store this medication in the bathroom or other damp areas.