Diaryl Tablet

Introduction

Diaryl Tablet 2 mg is an oral anti-diabetic drug used in the management of type 2 Diabetes mellitus. It helps reduce the blood glucose levels by increasing the production of insulin by the pancreas. Diaryl Tablet 2 mg works by stimulating the release of insulin produced in the pancreatic beta cells.

Uses

Diaryl Tablet 2 mg is used in the management of type 2 diabetes mellitus. It is used in combination with diet and exercise to improve blood sugar control.

Brand Name	Diaryl
Type	Tablet
Weight	2 mg
Generic	Glimepiride
Manufacturer	Beximco Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Diaryl Tablet 2 mg belongs to a class of medications known as sulfonylureas. It works by stimulating the release of insulin produced in the pancreatic beta cells.

How Long Does It Take To Work?

It usually takes Diaryl Tablet 2 mg about 2 to 4 weeks to show its full effect as it takes time for the body to adjust to the new medicine.

Absorption

Diaryl Tablet 2 mg is quickly and almost completely absorbed from the gastrointestinal tract. It reaches peak concentrations in the plasma after about 2-4 hours post-ingestion.

Route of Elimination

The majority of Diaryl Tablet 2 mg is eliminated in the urine, either as unchanged drug or in the form of metabolites. A small part of the drug is eliminated through the feces.

Dosage

In principle, the dosage of Glimepiride is governed by the desired blood sugar level. The dosage of Glimepiride must be the lowest which is sufficient to achieve the desired metabolic control. The initial and the maintenance doses are set based on the results of regular check of glucose in blood and urine. Monitoring of glucose levels in blood and urine also serves to detect either primary or secondary failure of therapy.

Initial dose and dose titration: the usual initial dose is 1 mg once daily, if necessary, the daily dose can be increased. Any increase can be based on regular blood sugar monitoring, and should be gradual, i.e., at intervals of 1 to 2 weeks, and carried out stepwise, as follows: 1 mg -> 2 mg -> 3 mg -> 4 mg -> 6 mg.

Dose in patients with well controlled diabetes: the usual dose range in patients with well controlled diabetes is 1 to 4 mg daily.

Distribution of doses: Timing and distribution of doses are decided by the physician, in consideration of the patient's current life-style. Normally, a single daily dose is sufficient. This should be taken immediately before a substantial breakfast or if none is taken immediately before the first main meal. It is very important not to skip meals after taking the drug.

Secondary dosage adjustment: As control of diabetes improves, sensitivity to insuiin increases; therefore, Glimepiride requirement may fall as treatment proceeds. To avoid hypoglycaemia, timely dose reduction or cessation of Glimepiride therapy must be considered. A dose adjustment must also be considered whenever the patient's weight or life-styie changes, or other factors arise which cause an increased susceptibility to hypo or hyperglycaemia.

Changeover from other oral antidiabetics to Glimepiride: There is no exact dosage relationship between Glimepiride and other oral blood sugar lowering agents. When substituting Glimepiride for other such agents, the initial daily dose is 1 mg; this applies even in changeover from maximum dose of other oral blood sugar lowering agents. Any dose increase should be in accordance with guideline given above in 'initial dose and dose titration'. Consideration must be given to the potency and duration of action of the previous blood sugar lowering agent. It may be necessary to interrupt treatment to avoid additive effects which would increase the risk of hypoglycaemia.

Diaryl Tablet 2 mg is available in the form of tablets ranging from 1 mg to 4 mg. The recommended starting dose is usually 1 mg once a day. The dose may be increased gradually, depending on the patient’s response to the drug. The maximum recommended dose is 6 mg once a day.

Administration

Diaryl Tablet 2 mg should be taken with or immediately after food to reduce the risk of side effects. It should be taken as directed by the doctor.

Side Effects

Common side effects of Diaryl Tablet 2 mg include nausea, dizziness, headache, diarrhea, blurred vision, and weight gain. More serious side effects such as low blood sugar levels, allergic reactions, and anemia may also occur.

Toxicity

Overdose of Diaryl Tablet 2 mg can lead to serious side effects such as low blood sugar levels, severe allergic reactions, and anemia. If an overdose is suspected, contact a doctor or poison control center immediately.

Precaution

Patients should tell their doctor about all medications and health conditions before taking Diaryl Tablet 2 mg. People who are allergic to sulfonamide-based drugs should not take Diaryl Tablet 2 mg. Women who are pregnant or breastfeeding should not take Diaryl Tablet 2 mg.

Interactions

Diaryl Tablet 2 mg may interact with a number of drugs, including certain beta blockers, ACE inhibitors, MAO inhibitors, and diuretics. Such interactions could lead to serious side effects. Patients should tell their doctor about all medications and health conditions before taking Diaryl Tablet 2 mg.

Disease Interaction

Patients with a history of liver or kidney disease should use Diaryl Tablet 2 mg with caution as it may worsen their condition. Patients with certain heart conditions should not take Diaryl Tablet 2 mg as it may increase the risk of certain heart conditions.

Drug Interaction

Diaryl Tablet 2 mg can interact with a number of other drugs, including certain beta blockers, ACE inhibitors, MAO inhibitors, and diuretics. Such interactions could lead to serious side effects. Patients should tell their doctor about all medications and health conditions before taking Diaryl Tablet 2 mg.

Food Interactions

Diaryl Tablet 2 mg should be taken with or immediately after food to reduce the risk of side effects. Patients should avoid taking alcohol while taking Diaryl Tablet 2 mg as this can increase the risk of low blood sugar levels.

Pregnancy Use

Diaryl Tablet 2 mg should not be used in pregnant women. It may harm the fetus if used during pregnancy. Women should avoid taking Diaryl Tablet 2 mg while pregnant or breastfeeding.

Lactation Use

It is not recommended to use Diaryl Tablet 2 mg when breastfeeding. It may harm the infant if taken while breastfeeding.

Acute Overdose

If an overdose of Diaryl Tablet 2 mg is suspected, contact a doctor or poison control center immediately. Symptoms of an overdose may include low blood sugar levels, severe allergic reactions, and anemia. Treatment of an overdose may involve the administration of dextrose or insulin as needed.

Contraindication

Diaryl Tablet 2 mg is contraindicated in people who are allergic to sulfonamide-based drugs, those with liver or kidney disease, and those with certain heart conditions, as well as in women who are pregnant or breastfeeding.

Use Direction

Patients should take Diaryl Tablet 2 mg exactly as prescribed by their doctor. The recommended starting dose is usually 1 mg once a day, taken with or immediately after food. The dose may be increased gradually, depending on the patient's response to the drug. The maximum recommended dose is 6 mg once a day.

Storage Condition

Diaryl Tablet 2 mg should be stored at room temperature, away from direct heat and moisture. Keep in a tight, light-resistant container. Keep out of the reach of children and pets.