Depnox SR Tablet (Sustained Release)

Depnox SR Tablet (Sustained Release) 150 mg

Depnox SR Tablet (Sustained Release) 150 mg (HCL), also known as Wellbutrin, is an atypical antidepressant used to treat major depression, seasonal affective disorder, and to help people stop smoking. It works by increasing certain types of brain activity that stimulate and regulate mood.

Uses

Bupropion HCL is used to treat Major Depressive Disorder, avoid smoking cessation, and dysthymia (a depression disorder).

Brand Name	Depnox SR
Type	Tablet (Sustained Release)
Weight	150 mg
Generic	Bupropion Hydrochloride
Manufacturer	Jayson Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Bupropion works by inhibiting the reuptake of dopamine and norepinephrine at the pre-synaptic neuron, increasing synaptic levels of dopamine and norepinephrine in the nucleus accumbens and frontal cortex. Bupropion also affects GABA by modulating ion channels and stimulating the release of these neurotransmitters.

How Long Does It Take To Work?

The length of time it takes for Bupropion to work depends on the individual. Generally, people begin to feel the effects of Bupropion within one to two weeks. Maximum effects may be seen two to four weeks after starting treatment.

Absorption

Bupropion is rapidly and extensively absorbed with oral administration. The absorption of Bupropion is not affected by food.

Route of Elimination

Bupropion is primarily eliminated by metabolites excreted in the urine.

Dosage

The usual adult target dose for Bupropion is 300 mg/day, given as 150 mg, twice daily. Dosing should begin at 150 mg/day given as a single daily dose in the morning. If the 150 mg initial dose is adequately tolerated, an increase to the 300 mg/day target dose, given as 150 mg twice daily, may be made as early as day 4 of dosing. There should be an interval of at least 8 hours between successive doses.

Increasing the dosage above 300 mg/day: As with other antidepressants, the full antidepressant effect of Bupropion Hydrochloride may not be evident until 4 weeks of treatment or longer. An increase in dosage to the maximum of 400 mg/day, given as 200 mg twice daily, may be considered for patients in whom no clinical improvement is noted after several weeks of treatment at 300 mg/day. Bupropion Hydrochloride should be discontinued in patients who do not demonstrate an adequate response after an appropriate period of treatment at 450 mg/day.

Maintenance: The lowest dose that maintains remission is recommended. Although it is not known how long the patient should remain on Bupropion Hydrochloride, it is generally recognised that acute episodes of depression require several months or longer of antidepressant drug treatment.

Child and adolescent: Not recommended for child and adolescent under 18 years of age.

The recommended dose for adults is 150-300mg/day in divided doses. The dose should not exceed 450mg/day. The dose may be increased at intervals of three days, not to exceed 150mg/day at any one time.

Administration

Bupropion may be taken with or without food. It should be swallowed whole, not crushed or chewed. Tablets should not be split.

Side Effect

Common side effects include: dry mouth, difficulty sleeping, headaches, nausea and constipation. Serious side effects include seizures, thoughts of suicide, changes in heart rate, and/or shortness of breath.

Toxicity

Bupropion is generally considered to have low toxicity, although there is a risk of overdose if multiple doses are taken. If an overdose is suspected, seek medical attention immediately.

Precautions

Patients should be advised of the risk of seizures, as well as the risk of new or worsening psychological symptoms. Bupropion can cause severe liver damage, and should not be taken by patients with liver problems.

Interaction

Bupropion may interact with certain drugs, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), or tricyclic antidepressants (TCAs). Other drugs that may interact include diuretics, lithium, and antipsychotics.

Disease Interactions

Bupropion should not be taken by patients with tri-iodothyronine (T3) deficiency, seizure disorder, anorexia or bulimia, liver or kidney disease, or bipolar disorder.

Drug Interactions

Certain drugs may interact with Bupropion, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), or tricyclic antidepressants (TCAs). Other drugs that may interact include diuretics, lithium, and antipsychotics.

Food Interactions

Bupropion should be taken with food to avoid stomach upset. Grapefruit or grapefruit juice may increase the amount of the drug in the body, so it is important to avoid grapefruit while taking medication.

Pregnancy Use

It is not recommended to take Bupropion during pregnancy due to possible side effects on the fetus. Patients should consult a doctor before taking this medication.

Lactation Use

It is not recommended to take Bupropion while breastfeeding, as it is passed into breast milk and can affect the infant. Patients should consult a doctor before taking this medication.

Acute Overdose

Signs of Bupropion overdose include dizziness, confusion, blurred vision, seizures, coma, and death. If an overdose is suspected, seek medical attention immediately.

Contraindication

Bupropion should not be taken by those who have a seizure or anorexia/bulimia history, liver or kidney disease, or bipolar disorder.

Use Direction

Bupropion should be taken as directed by a doctor. Most patients begin with a dose of 150 mg/day, which can be increased at intervals of three days, not to exceed 450mg/day.