Introduction
Zinc oxide is an inorganic compound used in a number of manufacturing processes. It can be found in rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced synthetically. It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.
Uses
Zinc oxide is a mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.
For adjunctive treatment of diaper dermatitis. Also, it can be used to treat minor skin irritations (eg, cuts, burns, and scrapes, poison ivy). Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light.
Associated Conditions
Pharmacodynamics
Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.
Mechanism of Action
It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.
Absorption
No significant percutaneous absorption from topically applied zinc oxide.
Volume of Distribution
Intended for local use only, no systemic absorption.
Protein Binding
Intended for local use only, no systemic absorption.
Route of Elimination
Intended for local use only, no systemic absorption.
Half Life
Intended for local use only, no systemic absorption.
Clearance
Intended for local use only, no systemic absorption.
Toxicity
Acute oral toxicity (LD50): 7950 mg/kg [Mouse].
Food Interactions
- Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
- Do not take with bran and high fiber foods. For optimal absorption, take zinc at least 2 hours before or after eating high-fiber foods.
- Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.
