Cortef IM/IV Injection

Cortef IM/IV Injection 100 mg/2 ml

Cortef IM/IV Injection 100 mg/2 ml is a steroid medication used to treat a variety of conditions, including allergies, asthma, arthritis, lupus, skin problems, and certain cancers. It is a synthetic form of the hormone cortisol, which is naturally produced in the body. Cortef IM/IV Injection 100 mg/2 ml reduces inflammation and irritations in the body and can be administered either orally or topically.

Uses For

Cortef IM/IV Injection 100 mg/2 ml is used to treat a variety of conditions such as allergies, asthma, arthritis, lupus, skin problems, and certain cancers. It is most commonly used to reduce inflammation of the skin, joints, respiratory system, and gastrointestinal tract.

Brand Name	Cortef
Type	IM/IV Injection
Weight	100 mg/2 ml
Generic	Hydrocortisone
Manufacturer	Aristopharma Ltd.
Available in	English বাংলা

Mechanism of Action

Cortef IM/IV Injection 100 mg/2 ml works by blocking the production of inflammatory compounds in the body. It works by inhibiting the activity of the enzyme phospholipase A2, which is responsible for releasing fatty acids from the cell membrane. These fatty acids are transformed into mediators of inflammation, such as prostaglandins and leukotrienes. By blocking phospholipase A2, hydrocortisone is able to reduce the production of these mediators of inflammation, ultimately reducing the inflammatory response.

How Long Does it Take to Work?

Most people find relief from hydrocortisone within 12-24 hours. However, this may vary depending on the severity of the condition and the individual’s response to the drug.

Absorption

Cortef IM/IV Injection 100 mg/2 ml is absorbed into the body through the digestive system, as well as through topical applications, by passing through the skin. The rate of absorption is largely dependent on the dosage and route of administration.

Route of Elimination

Cortef IM/IV Injection 100 mg/2 ml is eliminated from the body mainly through the kidneys. Small amounts are also eliminated in the feces and urine.

Dosage

Tablet: The initial dosage of Hydrocortisone Tablets may vary from 20 mg to 240 mg of hydrocortisone per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Hydrocortisone Tablets should be discontinued and the patient transferred to other appropriate therapy.

It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patients. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response. It should be kept in mind that constant monitoring is needed in regard to drug dosage. If, after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually, rather than abruptly.

Injection:

Adult: By IM injection or slow IV injection or infusion. The initial dose of Hydrocortisone sterile powder is 100 mg to 500 mg, depending on the severity of the condition. This dose may be repeated at intervals of 2, 4 or 6 hours as indicated by the patient's response and clinical condition.
Children: By slow IV injection, up to 1 year 25 mg, 1-5 years 50 mg, 6-12 years 100 mg.

The dosage of hydrocortisone varies by condition and individual needs. Generally, it is recommended to start at a low dose and gradually work up to the desired effect. Common oral doses range from 5 to 100mg per day. For topical application, it is usually applied once or twice daily. It is important to follow the instructions given by the healthcare provider.

Administration

Cortef IM/IV Injection 100 mg/2 ml can be administered orally, through injection, and topically as a cream, ointment, or lotion. Injections are generally used in severe cases and should only be done by a healthcare provider.

Side Effects

Cortef IM/IV Injection 100 mg/2 ml can cause a variety of side effects, including nausea, vomiting, dizziness, headache, stomach pain, changes in appetite, and swelling. Prolonged use may also lead to changes in facial features, weight gain, and changes in mood and behavior. It is important to talk to your healthcare provider about any side effects you experience while using hydrocortisone.

Toxicity

Cortef IM/IV Injection 100 mg/2 ml is generally well tolerated and is not considered toxic. Overdose symptoms may include nausea, vomiting, headache, dizziness, and changes in heart rate. If overdose is suspected, seek immediate medical attention.

Precautions

Cortef IM/IV Injection 100 mg/2 ml should be used with caution if you are pregnant, have liver or kidney disease, have a weakened immune system, or are taking other medications. It is also important to tell your doctor about any allergies or sensitivities to hydrocortisone, as well as any other medications you are taking. Your doctor may advise you to avoid direct exposure to the sun, as hydrocortisone can make your skin more sensitive to ultraviolet radiation.

Interactions

Cortef IM/IV Injection 100 mg/2 ml may interact with certain medications, including antifungals, antibiotics, diuretics, and oral contraceptives. It can also interact with foods such as caffeine, alcohol, and grapefruit juice. Be sure to inform your doctor of all medications and supplements you are taking before starting hydrocortisone.

Disease Interaction

Cortef IM/IV Injection 100 mg/2 ml may interact with certain underlying medical conditions, such as diabetes, high blood pressure, kidney or liver disease, and certain heart conditions. Talk to your doctor before starting hydrocortisone if you have any of these conditions.

Drug Interaction

Cortef IM/IV Injection 100 mg/2 ml may interact with certain medications, such as aspirin, warfarin, methotrexate, cyclosporine, and insulin. It can also interact with certain antibiotics and antifungals. Make sure to tell your doctor about any medications you are taking before starting hydrocortisone.

Food Interactions

Cortef IM/IV Injection 100 mg/2 ml may interact with certain foods, such as caffeine, alcohol, and grapefruit juice. Tell your doctor about any food or beverage you are currently consuming before starting hydrocortisone.

Pregnancy Use

Cortef IM/IV Injection 100 mg/2 ml should be used with caution during pregnancy. Talk to your doctor before taking hydrocortisone if you are pregnant or planning to become pregnant.

Lactation Use

Cortef IM/IV Injection 100 mg/2 ml is generally considered safe to take while breastfeeding, though it is always important to discuss this with your doctor first.

Acute Overdose

An acute overdose of hydrocortisone may cause nausea, vomiting, headache, dizziness, and changes in heart rate. If overdose is suspected, seek immediate medical attention.

Contraindication

Cortef IM/IV Injection 100 mg/2 ml should not be taken by people with an allergy or sensitivity to it, those with certain underlying medical conditions such as bleeding disorders, skin infections, and systemic fungal infections, or those who are pregnant. It is important to talk to your doctor before taking hydrocortisone.

Use Direction

Cortef IM/IV Injection 100 mg/2 ml is usually taken either orally or topically, depending on the condition being treated. Make sure to follow the instructions given by your healthcare provider. Do not increase or decrease the dose or frequency of use without consulting your doctor.

Storage Condition

Store in a tightly sealed container at room temperature, away from direct sunlight and moisture. Do not freeze. Keep out of the reach of children.

Volume of Distribution

Cortef IM/IV Injection 100 mg/2 ml is distributed throughout the body bound to proteins in the bloodstream. The volume of distribution is not well studied, but is estimated to be 0.14 L/kg.