Clomipramine Hydrochloride

Clomipramine Hydrochloride

Clomipramine Hydrochloride is a tricyclic antidepressant used to treat depression and other psychiatric disorders. It is also used to treat obsessive-compulsive disorder (OCD). Clomipramine Hydrochloride works by blocking certain chemical messengers in the brain that affect mood and emotion. It works by altering serotonin and norepinephrine levels in the brain.

Uses For

Clomipramine Hydrochloride is used to treat depression and other psychiatric disorders. It is also used to treat obsessive-compulsive disorder (OCD).

Mechanism Of Action

Clomipramine Hydrochloride blocks the reuptake of serotonin and norepinephrine in the brain. This increases the amount of these two neurotransmitters available to be used by neurons, which in turn leads to an improved mood and well being.

How Long Does It Take To Work?

Clomipramine Hydrochloride usually takes 4-6 weeks for its full effect. However, some people may notice some improvement of their symptoms within a few days of starting the drug.

Absorption

Clomipramine Hydrochloride is rapidly absorbed from the gastrointestinal tract and reaches its maximum concentration in about three hours. It has a bioavailability of 84%.

Route Of Elimination

Clomipramine Hydrochloride is metabolized in the liver by deamination and hydroxylation and is primarily excreted in the urine as metabolites.

Dosage

Initial dose is 25 mg at bed time about a week, gradual increase of dose should not be exceeded more than 150 mg per day in adult and 75 mg per day in elderly patient. Dose can be given as divided form to reduce gastrointestinal disturbances. Not recommended for children.

The usual initial adult dose of Clomipramine Hydrochloride is 25 mg given 3 or 4 times daily. The daily dose may then be increased by 25-50 mg every week in divided doses up to a maximum of 250 mg/day. It can also be given as a single daily dose, taken at bedtime.

Administration

Clomipramine Hydrochloride is provided as tablets and capsules that can be taken orally. It should be taken with food or a full glass of water to reduce the risk of stomach discomfort.

Side Effect

Common side effects of Clomipramine Hydrochloride include fatigue, drowsiness, nausea, dizziness, dry mouth, constipation, and blurred vision. More serious side effects can include seizures, difficulty breathing, chest pain, fast or irregular heart beat, and confusion.

Toxicity

Clomipramine Hydrochloride is generally well tolerated, but can be toxic if taken in large doses. Symptoms of toxicity include confusion, delirium, agitation, restlessness, increased heart rate, hypotension, seizures, and coma.

Precaution

Patients taking Clomipramine Hydrochloride should be monitored closely for suicidal thoughts or behavior, especially those with or at risk for depression. Patients should also be monitored for seizures, heart rhythm disturbances, and any other adverse reactions. Patients should contact their doctor if they experience any new or worsening symptoms while taking Clomipramine Hydrochloride .

Interaction

Clomipramine Hydrochloride can interact with other medications including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and warfarin. It can also interact with alcohol, some herbal products, and certain foods. Patients should inform their doctor about all medications they are taking before taking Clomipramine Hydrochloride .

Disease Interaction

Clomipramine Hydrochloride may interact with some diseases, including epilepsy, seizure disorders, bipolar disorder, heart rhythm disturbances, and glaucoma. Patients should inform their doctor of any existing medical conditions before taking Clomipramine Hydrochloride .

Drug Interaction

Clomipramine Hydrochloride can interact with other medications including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and warfarin. Patients should inform their doctor about all medications they are taking before taking Clomipramine Hydrochloride .

Food Interactions

Alcohol and certain foods can interact with Clomipramine Hydrochloride . Alcohol should be avoided when taking Clomipramine Hydrochloride . Certain foods such as cheese, liver, and tyramine containing products should also be avoided. Patients should inform their doctor of any dietary changes before taking Clomipramine Hydrochloride .

Pregnancy Use

Clomipramine Hydrochloride is classified as Pregnancy Category C. This means that it may not be safe for use by pregnant women. Patients should inform their doctor if they are pregnant or planning to become pregnant before taking Clomipramine Hydrochloride .

Lactation Use

Clomipramine Hydrochloride is classified as Lactation Risk Category B. This means that it is unlikely to harm a nursing infant. Patients should inform their doctor if they are breastfeeding or planning to breastfeed before taking Clomipramine Hydrochloride .

Acute Overdose

Symptoms of an acute overdose of Clomipramine Hydrochloride can include confusion, delirium, agitation, restlessness, increased heart rate, hypotension, seizures, and coma. In case of an overdose, patients should seek immediate medical attention.

Contraindication

Clomipramine Hydrochloride is contraindicated in patients with known hypersensitivity to the drug or its ingredients. It should also not be given to patients with glaucoma, seizure disorders, or a history of mania.

Use Direction

Clomipramine Hydrochloride should be taken exactly as prescribed by the doctor. The usual initial adult dose of Clomipramine Hydrochloride is 25 mg given 3 or 4 times daily. The daily dose may then be increased by 25-50 mg every week in divided doses up to a maximum of 250 mg/day. It can also be given as a single daily dose, taken at bedtime.

Storage Condition

Clomipramine Hydrochloride should be stored at room temperature, away from moisture and heat. It should be kept out of the reach of children.

Volume Of Distribution

Clomipramine Hydrochloride has a volume of distribution of 0.9 L/kg.

Half Life

Clomipramine Hydrochloride has a half life of 16-36 hours.

Clearance

Clomipramine Hydrochloride has a clearance of 1.6 mL/minute/kg.

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