Clincin Capsule

Clincin Capsule 300 mg Introduction

Clincin Capsule 300 mg is an antibiotic that is used in the treatment of certain types of bacterial infections. It belongs to the family of antibiotics known as lincomycin. Clincin Capsule 300 mg is available in tablets, capsules, lotion, topical solutions and creams. It works by stopping the growth of certain bacteria that cause infections.

Uses for Clincin Capsule 300 mg

Clincin Capsule 300 mg is used to treat a variety of bacterial infections. It can be used to treat bacterial infections of the skin, middle ear, bone, joint, urinary tract, lungs and vagina. It is also used to treat acne, bacterial vaginosis and prevention of infection after surgery.

Mechanism of Action

Clincin Capsule 300 mg works by interfering with the activity of bacterial enzymes which are essential for the development and spreading of bacteria. It prevents the bacteria from synthesizing proteins, which is necessary for its growth and reproduction. Clincin Capsule 300 mg also induces the breakdown of the cell walls of the bacterium, which is the final step in its elimination.

How Long Does it Take to Work?

Clincin Capsule 300 mg can start to work within 24 hours of taking the medication. It is important to complete the full course of treatment, even if the symptoms have improved. This helps to prevent the bacteria from becoming resistant to the medication.

Absorption

Clincin Capsule 300 mg is absorbed from the gastrointestinal tract, mainly from the small intestine. The absorption process is slowed down by taking the drug with food, milk, or an antacid. In general, absorption rate is slower when taken orally as compared to when taken intravenously.

Route of Elimination

Clincin Capsule 300 mg is mainly eliminated by the kidneys. Approximately 60-90% of the drug is excreted in the urine, whereas the remaining 10-40% is eliminated in the bile. It is important to drink plenty of water when taking clindamycin to help the kidneys excrete the drug out of the body.

Dosage

Dosage of Clindamycin Capsule:

Serious Infections: 150 mg-300 mg every six hours.
More severe infections: 300 mg-450 mg every six hours.

To avoid the possibility of oesophageal irritation, Clindacin capsules should be taken with a full glass of water.

Several researches has found that Clindamycin 300 mg capsule provides plasma concentration over MIC₉₀ for more than 12 hours. This finding supports the twice-daily dosing of Clindacin 300 mg capsule, particularly in SSTIs & RTIs. However, in case of bone & joint infections, diabetic foot infections dose of Clindamycin should be 300 mg capsule 3-4 times daily.

Dosage of Clindamycin Powder for oral solution:

Serious infections: 8-12 mg/kg/day divided into 3 or 4 equal doses.
Severe infections: 13-16 mg/kg/day divided into 3 or 4 equal doses.
More severe infections: 17-25 mg/kg/day divided into 3 or 4 equal doses.

In pediatric patients weighing 10 kg or less, 1/2 teaspoon (37.5 mg) three times a day should be considered the minimum recommended dose.

Dosage of Clindamycin IV/IM Injection:
Adults-

Serious infections due to aerobic gram-positive cocci and the more susceptible anaerobes: 600-1200 mg/day in 2- 4 equal doses.
More severe infections: 1200-2700 mg/day in 2-4 equal doses.
For more serious infections: these doses may have to be increased. In life-threatening situations due to either aerobes or anaerobes, these doses may be increased.
Doses of as much as 4800 mg daily have been given intravenously to adults. Single intramuscular injections of greater than 600 mg are not recommended.

Neonates (less than 1 month): 15 to 20 mg/kg/day in 3 to 4 equal doses. The lower effective dosage may be adequate for small prematures.

Pediatric patients (1 month of age to 16 years):

20 to 40 mg/kg/day in 3 or 4 equal doses. The higher doses would be used for more severe infections.
Parenteral therapy may be changed to Capsules (clindamycin hydrochloride) when the condition warrants and at the discretion of the physician.
In cases of (3-hemolytic streptococcal infections, treatment should be continued for at least 10 days.

Clincin Capsule 300 mg is available in tablets, capsules, lotion, topical solutions and creams.

Tablets: The usual adult dosage is 150 and 300 mg three times a day.
Capsules: The usual adult dosage is 300 to 600 mg three times a day.
Lotion: The usual adult dosage is 1% applied three or four times a day.
Topical solutions and creams: The usual adult dosage is 5 to 7 mg per kg of bodyweight daily.

Administration

Clincin Capsule 300 mg should be taken as directed by the doctor. It is usually taken orally, although it can also be taken intravenously. It is important to take it with food or milk to reduce the risk of stomach irritation.

Side Effect

Common side effects of clindamycin include diarrhea, stomach upset, nausea, vomiting, and abdominal pain. Other side effects include rash, nerve damage, kidney damage, and liver damage.

Toxicity

The most serious side effect of Clincin Capsule 300 mg is an allergic reaction, which can be life-threatening. Symptoms may include hives, difficulty breathing, and swelling of the face, lips, tongue, and throat. If an allergic reaction is suspected, it is important to stop taking the drug and seek medical attention immediately.

Precautions

Clincin Capsule 300 mg should not be taken if you are allergic to clindamycin or lincomycin. It should also not be taken if you have certain kidney or liver diseases. If you are pregnant or nursing, talk to your doctor before taking clindamycin to make sure it is safe. It is also important to tell your doctor about any other medications you are taking, as clindamycin may interact with certain drugs.

Interactions

Clincin Capsule 300 mg may interact with certain drugs, including other antibiotics, antifungals, statins, or nonsteroidal anti-inflammatory drugs. It may also interact with some vitamins and herbal supplements. It is important to tell your doctor about any other medications or supplements you are taking.

Disease Interactions

Clincin Capsule 300 mg can interact with certain medical conditions, such as renal impairment, gastrointestinal disease, or a history of pseudomembranous colitis. It is important to tell your doctor about any medical conditions you may have before taking clindamycin.

Drug Interactions

Clincin Capsule 300 mg may interact with other drugs, including antibiotics, antifungals, statins, or nonsteroidal anti-inflammatory drugs. It is important to tell your doctor about any other medications or supplements you are taking.

Food Interactions

Clincin Capsule 300 mg should be taken with food or milk to reduce the risk of stomach upset. It is important to avoid taking clindamycin with certain foods, such as dairy products, soy products, and high-fat foods.

Pregnancy Use

Clincin Capsule 300 mg is considered safe to take during pregnancy. However, it is important to talk to your doctor before taking clindamycin to make sure it is safe for both you and your baby.

Lactation Use

Clincin Capsule 300 mg may be excreted in breast milk. Therefore, it should be used with caution in breastfeeding mothers. It is important to talk to your doctor before taking clindamycin while breastfeeding.

Acute Overdose

Acute overdose of clindamycin can lead to vomiting, nausea, abdominal pain and diarrhea. If a person has overdosed, it is important to seek medical attention immediately.

Contraindication

Clincin Capsule 300 mg should not be taken if you are allergic to clindamycin or lincomycin. It should not be taken if you have certain kidney or liver diseases, or if you have a history of pseudomembranous colitis. It should also not be taken if you are pregnant or breastfeeding. It is important to tell your doctor about any medical conditions you may have before taking clindamycin.

Use Direction

Clincin Capsule 300 mg should be taken as directed by your doctor. It is usually taken orally, although it can also be taken intravenously. It is important to take it with food or milk to reduce the risk of stomach upset. It is also important to complete the full course of treatment, even if the symptoms have improved.

Storage Condition

Clincin Capsule 300 mg should be stored at room temperature, away from direct light and heat. It should also be kept out of reach of children and pets. Do not keep the drug in the bathroom, as it is prone to moisture.

Volume of Distribution

The volume of distribution of Clincin Capsule 300 mg is approximately 0.2 to 0.4 L/kg. This means that approximately 20-40% of the drug is distributed to the tissues in the body.

Half Life

The half-life of clindamycin is 3-5 hours. This means that it takes approximately 3-5 hours for half of the drug to be eliminated from the body.

Clearance

The clearance of clindamycin is approximately 0.3 to 0.6 mL/min/kg. This means that it takes around 18-36 minutes for the drug to be eliminated from the body.

See in details version Clincin Capsule 300 mg also Clincin Capsule 300 mg in bangla