Cdens Tablet

Introduction

Calcium orotate is a calcium salt of orotic acid, used as a dietary supplement. It is touted for its potential benefits in supporting bone health and overall calcium intake. Unlike other calcium salts, calcium orotate is believed to have better bioavailability, meaning it might be more easily absorbed and utilized by the body.

Uses

Calcium orotate is primarily used for:

Supplementing calcium levels to support bone health and prevent osteoporosis.
Providing additional calcium in individuals with dietary deficiencies or higher needs for calcium.
Supporting overall mineral balance in the body.

It is often used as a part of a dietary supplement regimen aimed at improving bone density and health.

Brand Name	Cdens
Type	Tablet
Weight	740 mg
Generic	Calcium Orotate
Manufacturer	Sanofi Bangladesh Ltd.
Available in	English বাংলা

Mechanism of Action

Calcium orotate releases calcium ions in the body, which are essential for various physiological processes. The orotate component is thought to facilitate the absorption and transport of calcium across cell membranes. This enhances the bioavailability of calcium, potentially improving its effectiveness in supporting bone health and other bodily functions.

How Long Does It Take to Work?

The onset of effects from calcium orotate supplementation can vary. Improvements in bone health and calcium levels may take several weeks to months of consistent use. The exact time frame can depend on individual factors such as baseline calcium levels, dietary intake, and overall health.

Absorption

Calcium orotate is believed to have higher bioavailability compared to other calcium salts, such as calcium carbonate or calcium citrate. The orotate form is more readily absorbed through the gastrointestinal tract and utilized by the body, allowing for efficient calcium uptake.

Route of Elimination

Excess calcium that is not utilized by the body is primarily eliminated through the kidneys via urine. A small amount of calcium is also excreted in feces. The orotate component is generally metabolized and excreted through the urine as well.

Dosage

Calcium Orotate 400 mg: As an addition to the daily diet, 2-3 tablets are usually recommended with meal or as directed by a physician.

Calcium Orotate 740 mg: As an addition to the daily diet, 1-2 tablets are usually recommended with meal or as directed by a physician.

The recommended dosage of calcium orotate can vary based on individual needs and specific health conditions. Common dosages range from 500 mg to 1000 mg per day, often divided into two or three doses. It is essential to follow product-specific guidelines or consult a healthcare provider to determine the appropriate dosage.

Administration

Calcium orotate is typically administered orally in the form of tablets, capsules, or powder. It is generally advised to take the supplement with meals to enhance absorption and minimize gastrointestinal discomfort. Always follow the dosage instructions provided on the product label or by a healthcare professional.

Side Effects

Potential side effects of calcium orotate include:

Gastrointestinal issues such as constipation, nausea, or bloating.
Headaches or dizziness in some individuals.

These side effects are generally mild and can often be managed by adjusting the dosage or taking the supplement with food.

Toxicity

Calcium orotate is considered to have a low risk of toxicity when used at recommended dosages. However, excessive intake of calcium can lead to hypercalcemia, which may cause symptoms such as nausea, vomiting, and kidney stones. Avoid exceeding the recommended dosage and consult a healthcare provider if symptoms of toxicity occur.

Precautions

Precautions include:

Monitor calcium intake to avoid excessive levels, especially if taking other calcium supplements or medications.
Individuals with kidney disease or a history of kidney stones should use calcium orotate cautiously.
Consult a healthcare provider before starting supplementation, especially if pregnant, breastfeeding, or taking other medications.

Always follow recommended guidelines to ensure safe and effective use.

Interaction

Calcium orotate may interact with:

Certain medications, such as diuretics or thyroid medications, which can affect calcium absorption or metabolism.
Other supplements, particularly those containing calcium or magnesium, which may require adjustment of dosages.

Inform your healthcare provider of all medications and supplements being taken to avoid potential interactions.

Disease Interaction

Use with caution in individuals with:

Kidney disorders or a history of kidney stones, as excessive calcium can exacerbate these conditions.
Hyperparathyroidism or other conditions affecting calcium metabolism.

Monitor health conditions and consult a healthcare provider for appropriate use in these cases.

Drug Interaction

Drug interactions may include:

Decreased absorption of certain antibiotics and medications if taken simultaneously with calcium orotate.
Potential interactions with medications that alter calcium metabolism, such as corticosteroids or anticonvulsants.

Consult a healthcare provider for personalized advice on drug interactions and management.

Food Interactions

Calcium orotate can be taken with or without food, but taking it with meals may enhance absorption and reduce gastrointestinal discomfort. Avoid consuming it with high-fiber foods or foods high in oxalates (e.g., spinach), which can inhibit calcium absorption.

Pregnancy Use

The safety of calcium orotate during pregnancy has not been extensively studied. It is important to use calcium supplements under the guidance of a healthcare provider during pregnancy to ensure appropriate dosing and to avoid excessive calcium intake.

Lactation Use

Calcium orotate is generally considered safe during lactation. It is important to ensure adequate calcium intake to support both maternal health and breastfeeding. Consult a healthcare provider for advice on appropriate supplementation during lactation.

Acute Overdose

Acute overdose of calcium orotate may result in hypercalcemia, presenting symptoms such as nausea, vomiting, and confusion. If an overdose is suspected, seek medical attention immediately. Supportive care and monitoring of calcium levels may be required.

Contraindication

Calcium orotate should be avoided in individuals with:

Known hypersensitivity to calcium orotate or its components.
Severe kidney impairment or a history of kidney stones without medical supervision.

Ensure to consult a healthcare provider to determine if calcium orotate is appropriate for your health condition.

Use Direction

Follow the product label for specific dosing instructions. Take the supplement with meals to enhance absorption and reduce gastrointestinal discomfort. Avoid exceeding the recommended dosage and consult a healthcare provider for any concerns about its use.

Storage Conditions

Store calcium orotate in a cool, dry place away from direct light and moisture. Keep the product tightly closed and out of reach of children. Follow any specific storage instructions provided on the product label.

Volume of Distribution

The volume of distribution for calcium orotate is not typically specified, as it is primarily a dietary supplement with localized absorption and minimal systemic distribution. The effectiveness is mainly related to its role in supporting bone health and calcium levels.

Half Life

The half-life of calcium orotate is not well-defined due to its localized use and minimal systemic absorption. The effects on calcium levels are typically monitored through ongoing supplementation rather than specific pharmacokinetic measurements.

Clearance

Calcium orotate is primarily cleared from the body through urinary excretion of calcium and minimal amounts of the orotate component. The clearance rate is influenced by factors such as renal function and calcium metabolism.

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