Carbotin IV Infusion

Introduction

Carbotin IV Infusion 10 mg/ml is a chemotherapy drug, also known as a cytotoxic agent, which is used to treat a variety of cancers such as ovarian, lung, and bladder cancer. It is an analogue of cisdiamminedichloroplatinum(II), commonly referred to as cisplatin. It works by inhibiting Division of cancer cells. Carbotin IV Infusion 10 mg/ml is usually used in combination with other chemotherapeutic agents and radiation therapy.

Uses For

Carbotin IV Infusion 10 mg/ml is used for the treatment of:

Cervical Cancer
Breast Cancer
Lung Cancer
Ovarian Cancer
Small Cell Lung Cancer
Neuroblastoma
Pancreatic Cancer
Thyroid Cancer

Brand Name	Carbotin
Type	IV Infusion
Weight	10 mg/ml
Generic	Carboplatin
Manufacturer	Techno Drugs Ltd.
Available in	English বাংলা

Mechanism of Action

Carbotin IV Infusion 10 mg/ml is an analogue of cisplatin, both of which are platinum-based chemotherapy drugs. It works by crosslinking DNA strands, leading to apoptosis in cells, and ultimately, cell death. This leads to reduced growth and division of cancer cells, which in turn leads to a reduction in the size of tumours.

How Long Does it Take to Work?

Carbotin IV Infusion 10 mg/ml usually takes 3-4 weeks to show signs of significant effectiveness. Patients may begin to experience relief from symptoms associated with their cancer within weeks of the initial treatment, although this varies from case to case.

Absorption

Carbotin IV Infusion 10 mg/ml is absorbed rapidly and almost completely after intravenous administration, with peak plasma concentrations occurring in approximately 1 – 2 hours.

Route of Elimination

Carbotin IV Infusion 10 mg/ml is excreted mainly via the kidneys. Approximately 70% is excreted in the urine as unchanged, parent drug and its metabolites, while the remainder is excreted in the feces via biliary elimination.

Dosage

Needles or intravenous sets containing aluminum parts that may come in contact with Carboplatin injection should not be used for the preparation or administration. Aluminum reacts with Carboplatin causing precipitate formation and/or loss of potency. Procedures for proper handling and disposal of anti-cancer drugs should be implemented. Several guidelines on this subject have been published. There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.

After dilution, Carboplatin should be used by the intravenous route only. The recommended dosage of Carboplatin in previously untreated adult patients with normal kidney function is 400 mg/m2 as a single I.V. dose administered by a 15 to 60 minute infusion. Therapy should not be repeated until four weeks after the previous Carboplatin course and/or until the neutrophil count is at least 2000 cells/mm3 and the platelet count is at least 100,000 cells/mm3 . Reduction of the initial dosage by 20-25% (i.e, 300-320 mg/m2) is recommended for those patients who present with risk factors such as prior myelosuppressive treatment and low performance status (ECOG-Zubrod 2-4 or Karnofsky below 80). For patients age 65 and over, dosage adjustment, initially or subsequently, may be necessary, dependent on the physical condition of
the patient.

Determination of the hematologic nadir by weekly blood count during the initial courses of treatment with Carboplatin is recommended for dosage adjustment for subsequent courses of therapy. The dose of Carbotin IV Infusion 10 mg/ml for adult is generally between 400-600 mg/m2 intravenously over 1-2 hours. Dosage depends on the patient’s body surface area, type of cancer and other medical conditions. It is typically given every 4 weeks.

Administration

Carbotin IV Infusion 10 mg/ml is typically given intravenously (IV) via a pump. It can also be given via intramuscular injections, although this is less common.

Side Effect

Common side effects associated with Carbotin IV Infusion 10 mg/ml include:

Hair loss
Nausea and vomiting
Diarrhea
Mouth sores
Fatigue
Anemia
Low white blood cell count
Low platelet count
Skin rash or discoloration

Toxicity

High doses of Carbotin IV Infusion 10 mg/ml can cause serious, or even fatal, toxicity. Common signs of toxicity include hearing loss, confusion, and altered mental status.

Precautions

Patients with pre-existing heart, kidney, or liver disease should be monitored closely while taking Carbotin IV Infusion 10 mg/ml.
Men may experience infertility with prolonged use.
Women should avoid breastfeeding while taking Carbotin IV Infusion 10 mg/ml.
Carbotin IV Infusion 10 mg/ml may cause fetal harm, so pregnant women should not take this medication.
Patients should avoid consuming alcohol while taking Carbotin IV Infusion 10 mg/ml.

Interaction

Carbotin IV Infusion 10 mg/ml may interact with other medications, including antibiotics, antivirals, antifungals, and immunosuppressants.

Disease Interaction

Carbotin IV Infusion 10 mg/ml may interact with certain medical conditions, so it is important to speak to your doctor before taking the medication if you have any of the following:

Kidney Disease
Liver Disease
Hearing Loss
Bone Marrow Suppression

Drug Interaction

Carbotin IV Infusion 10 mg/ml may interact with certain medications, including antibiotics, antivirals, antifungals, and immunosuppressants, so it is important to speak to your doctor before taking Carbotin IV Infusion 10 mg/ml if you are taking any of the following:

Aminoglycoside Antibiotics (such as Amikacin or Gentamicin)
Anticoagulants (such as Warfarin or Heparin)
Interferon-Based Medications (such as Peginterferon alfa-2a)
Antivirals (such as Ribavirin)
Immunosuppressants (such as Azathioprine or Cyclosporine)

Food Interactions

Before taking Carbotin IV Infusion 10 mg/ml, speak to your healthcare provider about potential food interactions.

Pregnancy Use

Carbotin IV Infusion 10 mg/ml should be avoided in pregnant women as it may cause fetal harm.

Lactation Use

Carbotin IV Infusion 10 mg/ml should be avoided in breastfeeding women as it may pass into breast milk and cause harm to an infant.

Acute Overdose

Symptoms of acute overdose may include vomiting, confusion, hearing loss, seizures, and coma. If an acute overdose occurs, medical attention should be sought right away.

Contraindication

Carbotin IV Infusion 10 mg/ml should not be used in patients who are allergic to its components.

Use Direction

Carbotin IV Infusion 10 mg/ml should be taken exactly as prescribed by your healthcare provider. Do not change the dose or stop taking the medication without consulting your doctor.