Calupros Tablet

Introduction

Calupros Tablet 50 mg is a non-steroidal synthetic antiandrogen medication that is used primarily in the treatment of prostate cancer. It is taken by mouth in the form of a pill or tablet and is chemically related to flutamide, another non-steroidal antiandrogen.

Uses

Calupros Tablet 50 mg is used in combination with a gonadotropic hormone analogue such as a luteinizing releasing hormone analogue (LHRH analogue) or a gonadotropin-releasing hormone agonist to treat prostate cancer. Calupros Tablet 50 mg blocks the effects of testosterone on the prostate gland, thus, resulting in tumor regression.

Brand Name	Calupros
Type	Tablet
Weight	50 mg
Generic	Bicalutamide
Manufacturer	Everest Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Calupros Tablet 50 mg binds to a group of steroid hormone receptors called androgen receptors, which are found in target tissue in the prostate gland and other sites throughout the body. It prevents testosterone and dihydrotestosterone from binding to androgen receptors, interfering with their ability to send signals to the prostate gland and other tissues. This prevents the prostate gland from producing other hormones that are involved in prostate cell growth and proliferation.

How Long Does it Take To Work?

It can take up to 4-6 weeks for bicalutamide to start working. It is not recommended to stop taking bicalutamide without consulting with a physician.

Absorption

Calupros Tablet 50 mg is rapidly and completely absorbed following oral administration. The bioavailability of the drug is approximately 90%, meaning that approximately 90% of the drug is able to reach the circulation and be available for use.

Route of Elimination

Calupros Tablet 50 mg is eliminated from the body primarily via the urine and to a lesser extent, through the feces. Calupros Tablet 50 mg is extensively metabolized in the liver and excreted in the urine.

Dosage

The recommended dose for Bicalutamide therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening), with or without food.

Pediatric Use: The safety and effectiveness of Bicalutamide in pediatric patients have not been established.

Hepatic Impairment: Bicalutamide is extensively metabolized by the liver. It should be used with caution in patients with moderate-to-severe hepatic impairment.

The usual dosage of bicalutamide for the treatment of prostate cancer is one 50 mg tablet once per day. It can be taken either with or without food. It is important to note that bicalutamide may interact with other medications and should not be taken with certain drugs. Be sure to consult with a doctor before taking it.

Administration

Calupros Tablet 50 mg should be taken orally with or without food once daily. It is important to take the medication at the same time each day to maintain a consistent level of the drug in the body.

Side Effects

Common side effects of bicalutamide include fatigue, hot flashes, nausea, vomiting, diarrhea, constipation, muscle pain, joint pain, lightheadedness, headache, difficulty sleeping, and weight gain. Other serious side effects can include liver damage, blood clots, or an irregular heartbeat. If any of these side effects occur, be sure to speak to a doctor.

Toxicity

Calupros Tablet 50 mg has a low potential for toxicity due to its low levels of absorption and low degree of protein binding. If the medication is ingested in large quantities, it can be associated with liver and kidney damage. It is important to speak to a doctor before taking bicalutamide.

Precautions

Do not take bicalutamide if you are pregnant, planning to become pregnant, or breastfeeding.
Patients should be aware that bicalutamide may interact with other medications and should not be taken with certain drugs.
If you have had a heart attack, stroke, or another type of heart disease, be sure to tell your doctor before taking bicalutamide.
Be sure to tell your doctor if you are taking any other medications, including over-the-counter medications and herbal supplements as they can interact with bicalutamide.
Patients with severe hepatic impairment or end-stage renal disease should not take bicalutamide.

Interactions

Calupros Tablet 50 mg may interact with other medications. It is important to tell your doctor if you are taking any other medications, including over-the-counter medications and herbal supplements as they can interact with bicalutamide.

Disease Interactions

There are many diseases that may interact with bicalutamide, such as kidney disease, liver disease, prostate cancer, and heart disease. Be sure to talk to your doctor about any medical conditions you have before taking bicalutamide.

Drug Interactions

Calupros Tablet 50 mg can interact with other medications, so it is important to tell your doctor if you are taking any other medications, including over-the-counter medications and herbal supplements as they may interact with bicalutamide.

Food Interactions

Calupros Tablet 50 mg is not known to interact with food, however, it is important to tell your doctor about any changes in your diet before taking bicalutamide.

Pregnancy Use

Calupros Tablet 50 mg is not recommended for use in pregnant women. There is the potential for harm to an unborn baby and therefore it is advised to avoid using the medication during pregnancy.

Lactation Use

Calupros Tablet 50 mg should not be used by women who are breastfeeding. It is unknown if the drug is passed through breast milk, and the potential risk to an infant is not known.

Acute Overdose

In the event of an overdose, contact a healthcare provider or poison control center immediately. Symptoms of an overdose may include nausea, vomiting, drowsiness, difficulty breathing, dizziness, and an irregular heartbeat.

Contraindication

Calupros Tablet 50 mg should not be used in patients with severe hepatic impairment or end-stage renal disease.

Use Direction

Calupros Tablet 50 mg should be taken orally with or without food once daily, at about the same time each day. Additionally, make sure to talk to your doctor about any other medications you are taking, as bicalutamide may interact with them.