Burnrid Cream

Burnrid Cream 1%

Silver sulfadiazine, also known as SSD or silvadene, is an antibacterial topical cream used to treat wounds such as burns, skin ulcers, and post-surgical wounds. It is composed of silver and sulfadiazine. Silver sulfadiazine has been used for over 50 years and is widely used to treat infected wounds as it is effective against a broad spectrum of bacteria, including Gram-positive and Gram-negative, as well as fungi.

Uses For Burnrid Cream 1%

Silver sulfadiazine is primarily used for the prevention and treatment of infection in wounds such as burns, skin ulcers, and post-surgical wounds. It is also used to treat and prevent secondary infections in trauma-related skin damage.

Brand Name	Burnrid
Type	Cream
Weight	1%
Generic	Silver Sulfadiazine
Manufacturer	Globe Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Silver sulfadiazine works by blocking bacterial proteins in the skin, inhibiting the growth of bacteria. Silver ions destroy essential structures such as cell walls and DNA within the bacteria, causing their death. Silver sulfadiazine also acts as an antifungal agent due to its fungistatic properties.

How Long Does It Take To Work?

Silver sulfadiazine is a fast-acting topical cream, with effects seen within a few hours of application. It can be used to heal and prevent infection in wounds very quickly, and typically does not require any prescription.

Absorption

Silver sulfadiazine is a topical cream, so it is not absorbed through the skin. It only works when applied directly to the wound. It is not recommended to be taken internally as it can be toxic.

Route of Elimination

Silver sulfadiazine is excreted in sweat, urine, and feces in humans. It is not metabolized in the body, rather it is eliminated as it is taken in.

Dosage

The burn wounds are cleansed, and Silver Sulfadiazine is applied over the burn wound. The burn areas should be covered with Silver Sulfadiazine at all times. The cream should be applied once to twice daily to a thickness of approximately 1/16 inches or 1.5 mm. Whenever necessary; the cream should be reapplied to any areas from which it has been removed by patient activity. If individual patient requirements make dressings necessary, they may be used. Reapplication should be ensured immediately after hydrotherapy. Treatment with Silver Sulfadiazine should be continued until satisfactory healing is occurred, or until the burn site is ready for grafting. The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.

The recommended dose of silver sulfadiazine will vary depending on the patient and the severity of the wound. It is usually administered topically in a cream form two to four times a day. In general, the frequency of application and the amount of silver sulfadiazine is determined by the wound size. For adults, apply a thin layer of 1% cream over the entire wound area two to three times daily and cover with an occlusive bandage or dressing. For children, apply one to two times daily as directed by their doctor.

Administration

Silver sulfadiazine should be applied topically, directly to the wound. The cream should be applied thinly over the affected area two to three times daily. An occlusive, breathable dressing, such as gauze or a transparent film dressing, should be used to cover the wound. This helps to keep the silver sulfadiazine cream in the wound area and away from healthy skin.

Side Effect

The most common side effects of silver sulfadiazine are mild and transient stinging or burning where applied and dryness. Other reported side effects include rash, hives, itching, redness, or shortness of breath. If these symptoms persist or worsen, contact a doctor.

Toxicity

Silver sulfadiazine is safe when used as directed, however it can be toxic when taken internally. Overdoses of silver sulfadiazine may cause vomiting, headache, nausea, and abdominal pain, as well as severe kidney and liver damage.

Precautions

Before using silver sulfadiazine, it is important to inform your doctor if you have ever had any adverse reactions to sulfonamides or silver-based medications. The cream should not be used on patients who are hypersensitive or allergic to sulfonamides or silver compounds. Do not use silver sulfadiazine on open wounds or on areas of the skin which are inflamed, infected, or irritated. Silver sulfadiazine cream should be applied in a thin layer and covered with an occlusive dressing or bandage. Do not apply the cream near the eyes or mouth.

Interaction

Silver sulfadiazine may interact with other medications, including antacids, tetracyclines, macrolides, anticoagulants, ACE inhibitors, statins, and sulfonylureas. Always inform your doctor about any other medications you are taking before using silver sulfadiazine.

Disease Interactions

Silver sulfadiazine may interact with certain medical conditions, including G6PD deficiency, kidney and liver disease, and autoimmune disorders. It is important to inform your doctor of any medical condition before using silver sulfadiazine.

Drug Interactions

Silver sulfadiazine may interact with certain medications, including antacids, tetracyclines, macrolides, anticoagulants, ACE inhibitors, statins, and sulfonylureas. Always inform your doctor of any medications you are taking before using silver sulfadiazine.

Food Interactions

Silver sulfadiazine is not known to interact with food.

Pregnancy Use

Silver sulfadiazine should not be used during pregnancy as it may cause harm to a developing fetus. If you are pregnant or planning to become pregnant, consult your doctor before using silver sulfadiazine.

Lactation Use

Silver sulfadiazine should not be used during lactation as it may cause harm to the infant. It is not known if this drug is excreted in human milk. Consult your doctor before using silver sulfadiazine.

Acute Overdose

An overdose of silver sulfadiazine can be dangerous. If an overdose is suspected, seek medical help immediately.

Contraindication

Silver sulfadiazine should not be used in patients who are allergic or hypersensitive to sulfonamides or silver-based medications. It should also not be used on open wounds or on areas of the skin which are inflamed, infected, or irritated.

Use Directions

Apply a thin layer of 1% cream over the entire wound area two to three times daily and cover with an occlusive bandage or dressing. Avoid any contact with eyes and wash the hands after application. Do not use on open wounds.