Bromazepam

Introduction

Bromazepam is a benzodiazepine drug used primarily for the short term treatment of anxiety, panic or insomnia. The drug works by affecting the mechanics of the brain and central nervous system to produce a calming effect. It is typically prescribed for short-term use only as it can be habit-forming and cause withdrawal symptoms upon abrupt discontinuation.

Uses

Bromazepam is used to alleviate symptoms related to anxiety, panic, or insomnia. It is not recommended for long-term or regular use as it can lead to psychological and physical dependency, or tolerance to the drug.

Brand Name	Bromazepam
Type
Weight
Generic	Bromazepam
Manufacturer
Available in	English বাংলা

Mechanism of Action

Bromazepam binds to the gamma-aminobutyric acid (GABA) receptor in the brain and central nervous system. By doing so, it produces an increased amount of GABA, an inhibitory neurotransmitter, which has an anxiolytic, anticonvulsant, and sedative action.

How Long Does it Take to Work?

Bromazepam usually begins to work 30 to 60 minutes after it is consumed and can last for up to 6 hours.

Absorption

Bromazepam is rapidly and completely absorbed after oral administration.

Route of Elimination

Bromazepam is primarily metabolized through the cytochrome P450 enzyme in the liver. The majority of the drug is then excreted through urine, followed by the liver and feces.

Dosage

Standard dosage: Average dosage for outpatient therapy is 1.5-3 mg up to three times daily. Treatment of outpatients should begin with low doses, gradually increasing to the optimum level.

In severe cases, especially in hospital: 6-12 mg 2 or 3 times daily. The overall treatment generally should not be more than 8-12 weeks. In certain cases extension beyond the maximum treatment period may be necessary; if so, it should be taken with re-evaluation of the patient's status with special expertise.

Elderly and debilitated patients: Elderly patients and those with impaired hepatic functions require lower doses.

Children: Bromazepam is usually not indicated in children, but if the physician feels bromazepam treatment is appropriate, then the dose should be adjusted to their low bodyweight (about 0.1-0.3 mg/kg bodyweight) The recommended dosage of Bromazepam ranges from 3 milligrams to 15 milligrams per day. As this is a powerful medication, it should be consumed only when prescribed by a doctor. The dosage should not exceed the amount prescribed by the doctor as it can be habit-forming.

Administration

Bromazepam should be taken orally with a glass of water. It is typically taken one to three times daily as needed, depending on the prescribed dosage.

Side Effects

Common side effects associated with Bromazepam include drowsiness, impairment of coordination, drowsiness, memory problems, nausea, confusion, slowed reflexes, and a decreased motor skills.

Toxicity

Excessive dosage and/or prolonged use of Bromazepam can lead to a buildup of tolerance and physical and psychological dependency. Symptoms of overdose include disorientation, drowsiness, impaired reflexes, shallow respiration, low blood pressure, and coma. Call a poison control center or medical facility immediately if you suspect an overdose.

Precaution

It is important to practice precaution while taking Bromazepam as it can be habit-forming. It is not recommended for patients suffering from conditions such as acute narrow-angle glaucoma, kidney or liver failure, or severe depression. Bromazepam should also not be taken with other sedatives, alcohol, or drugs that can affect the central nervous system.

Interaction

Bromazepam should not be taken with other drugs that can affect the central nervous system, alcohol, or other sedatives. In addition, it may interact with certain medications, such as antipsychotics, anticonvulsants, and birth control pills.

Disease Interaction

Bromazepam should not be taken if the patient has a history of acute narrow-angle glaucoma, kidney or liver failure, or severe depression.

Drug Interaction

Bromazepam may interact with certain drugs, such as antipsychotics, anticonvulsants, and birth control pills.

Food Interactions

Bromazepam may interact with certain foods, such as grapefruit, orange, and apple juice. It is best to avoid eating these when taking Bromazepam .

Pregnancy Use

Bromazepam is not recommended during pregnancy due to the potential for side-effects and dependency.

Lactation Use

It is not recommended to take Bromazepam while breastfeeding as it can pass through the mother’s milk and affect the infant.

Acute Overdose

Symptoms of an overdose include disorientation, drowsiness, impaired reflexes, shallow respiration, low blood pressure, and coma. If you suspect an overdose, contact a poison control center or medical facility as soon as possible.

Contraindication

Bromazepam should not be taken with other sedatives, alcohol, or drugs that can affect the central nervous system. In addition, it should not be taken if the patient has a history of acute narrow-angle glaucoma, kidney or liver failure, or severe depression.

Use Direction

Bromazepam should be taken orally with a glass of water one to three times daily, as prescribed by a doctor. The dosage should not exceed the prescribed amount as it can be habit-forming.

Storage Condition

Bromazepam tablets should be stored at room temperature, away from heat and light. It should be kept in its original container.

Volume of Distribution

Bromazepam has a volume of distribution of approximately 240 liters per kilogram.

Half Life

Bromazepam has an elimination half-life of 8-15 hours.

Clearance

Bromazepam has a hepatic clearance of 0.41 liters per hour per kilogram.

See in details version Bromazepam also Bromazepam in bangla

Some Frequently Asked Questions About Bromazepam