Bendil Cream

Introduction

Bendil Cream 2%+0.1% is a combination of two agents with different therapeutic effects. Diphenhydramine Hydrochloride is an antihistamine commonly used to treat allergy symptoms, such as sneezing, itching, and runny nose. Zinc Acetate is a zinc salt that is often used to treat or prevent zinc deficiency and has potential benefits for skin and immune health. When combined, this formulation is typically used to address symptoms associated with allergies and to provide additional benefits from zinc supplementation.

Uses

Bendil Cream 2%+0.1% is used for:

Relieving symptoms of allergic reactions such as sneezing, itching, and nasal congestion
Managing symptoms of the common cold, including cough and runny nose
Reducing symptoms associated with zinc deficiency
Supporting skin health and immune function due to zinc's role in wound healing and immune support

Brand Name	Bendil
Type	Cream
Weight	2%+0.1%
Generic	Diphenhydramine Hydrochloride + Zinc Acetate
Manufacturer	Alco Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Diphenhydramine Hydrochloride works by blocking histamine H1 receptors, reducing the effects of histamine, a substance that causes allergic symptoms. This leads to relief from symptoms such as itching, sneezing, and nasal congestion. Zinc Acetate provides zinc, an essential mineral that plays a critical role in various biological processes, including immune function, cell division, and protein synthesis. It can help reduce the severity and duration of cold symptoms and support overall skin health.

How Long Does It Take to Work?

Diphenhydramine Hydrochloride typically starts to work within 15 to 30 minutes after administration, with peak effects occurring within 1 to 2 hours. Zinc Acetate may take a few days to weeks to exert its full benefits, especially if used for treating or preventing zinc deficiency.

Absorption

Diphenhydramine is absorbed rapidly from the gastrointestinal tract, with peak plasma concentrations reached within 1 to 2 hours. Zinc Acetate is also well-absorbed from the gastrointestinal tract, with bioavailability enhanced by the presence of food.

Route of Elimination

Diphenhydramine is primarily metabolized in the liver and excreted in the urine. Zinc Acetate is absorbed into the bloodstream and then excreted mainly through the urine, with a small amount eliminated through feces.

Dosage

Adults & children above 2 years: Apply to the affected area 3 to 4 times daily. Before application of cream, the skin should be clean, cool and dry. Should not have a hot shower or bath before applying. Apply the cream lightly on the skin until the cream disappears. It is important to include all skin surfaces, such as between the fingers and toes, under the nails and on the soles of the feet.

For babies under 2 years: Initially consult with the physician, if it is recommended, apply to the face, neck, ears and scalp as well, only avoiding the area immediately around the eyes and mouth. Leave cream on for at least 8 hours, before washing off. Reapply to any area that may be washed during the 8 hours treatment time (such as after washing the hands).

The dosage for Bendil Cream 2%+0.1% can vary depending on the specific formulation and intended use. Typical dosages are as follows:

Diphenhydramine Hydrochloride: 25-50 mg every 4-6 hours, not to exceed 300 mg per day.
Zinc Acetate: 25-50 mg daily, depending on the level of zinc deficiency or supplementation needs.

Administration

This combination is typically administered orally, in the form of tablets, capsules, or liquid. It should be taken with water, and the dosage should not exceed the recommended amount. For best results, follow the dosage instructions provided on the product label or by a healthcare provider.

Side Effects

Potential side effects include:

Diphenhydramine: Drowsiness, dizziness, dry mouth, constipation, blurred vision, and urinary retention.
Zinc Acetate: Nausea, vomiting, metallic taste, and stomach upset. High doses may lead to more severe symptoms like gastrointestinal distress and impaired immune function.

Toxicity

Diphenhydramine toxicity can occur if taken in excessive amounts, leading to symptoms such as extreme drowsiness, confusion, hallucinations, and seizures. Zinc toxicity can result from prolonged high doses, causing nausea, vomiting, diarrhea, and in severe cases, damage to the gastrointestinal tract and kidneys.

Precautions

Precautions should be taken if you have:

Pre-existing medical conditions such as liver disease, kidney disease, or gastrointestinal disorders
Known allergies to either diphenhydramine or zinc
Pregnancy or breastfeeding status, as the safety of this combination during these periods should be discussed with a healthcare provider

Interaction

Bendil Cream 2%+0.1% may interact with:

Other central nervous system depressants, increasing drowsiness and sedation
Antacids and certain antibiotics, which can affect zinc absorption
Medications metabolized by the liver, due to potential interactions with diphenhydramine

Disease Interaction

Special consideration is needed for individuals with:

Kidney or liver disorders, as these may affect the metabolism and excretion of diphenhydramine and zinc
Peptic ulcers or gastrointestinal conditions, which may be exacerbated by zinc supplementation

Drug Interaction

Potential drug interactions include:

Alcohol and other sedatives, which can enhance the drowsiness caused by diphenhydramine
Diuretics, which may increase zinc excretion
Antihypertensive drugs, as diphenhydramine may affect blood pressure control

Food Interactions

Food interactions are minimal, but it is generally recommended to take zinc supplements with food to reduce gastrointestinal irritation. Diphenhydramine should be taken as directed, with or without food.

Pregnancy Use

The use of Bendil Cream 2%+0.1% during pregnancy should be discussed with a healthcare provider. Diphenhydramine is classified as a Category B drug, indicating that it is generally considered safe but should be used only if clearly needed. Zinc is essential during pregnancy, but supplementation should be managed carefully to avoid excessive intake.

Lactation Use

Diphenhydramine is excreted in breast milk, and its use should be evaluated for potential effects on a nursing infant. Zinc supplementation is typically safe during lactation, but high doses should be avoided to prevent any adverse effects on both mother and baby.

Acute Overdose

Acute overdose of Diphenhydramine Hydrochloride can result in severe drowsiness, confusion, hallucinations, and other anticholinergic effects. Zinc overdose may lead to gastrointestinal symptoms and potentially more severe health issues. In case of overdose, seek immediate medical attention.

Contraindication

This combination is contraindicated in individuals with:

Allergic reactions to diphenhydramine or zinc
Severe liver or kidney disease
Peptic ulcer disease or gastrointestinal disorders that may be aggravated by zinc

Use Direction

Follow the dosage instructions provided by the manufacturer or a healthcare provider. Generally, take the combination with water and do not exceed the recommended dosage. Consult a healthcare provider for any specific concerns or if symptoms persist.

Storage Conditions

Store Bendil Cream 2%+0.1% in a cool, dry place, away from direct sunlight and moisture. Keep the product in its original container and out of reach of children. The recommended storage temperature is between 15°C and 30°C (59°F and 86°F).

Volume of Distribution

The volume of distribution for Diphenhydramine Hydrochloride is approximately 3-5 liters per kilogram, indicating its distribution throughout the body tissues. Zinc has a variable volume of distribution depending on body stores and is distributed to various tissues, including muscles and bones.

Half Life

The half-life of Diphenhydramine Hydrochloride is about 4-8 hours, while the half-life of zinc is not well-defined but is influenced by factors such as dietary intake and body zinc stores.

Clearance

Diphenhydramine is cleared primarily through the kidneys, with a clearance rate that can be affected by age and liver function. Zinc clearance is also through the kidneys, with excess amounts excreted in the urine.

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