Barbit Tablet

Introduction

Barbit Tablet 30 mg is a barbiturate with sedative-hypnotic, anticonvulsant, and antiarrhythmic properties; it is also used as an adjunct in the management of pain. Barbit Tablet 30 mg is used in the short-term treatment of severe insomnia. It is also used in seizure disorders, particularly when other medications do not control the seizures.

Uses for

Barbit Tablet 30 mg is primarily used in the treatment of seizure disorders, including partial seizures, tonic-clonic (generalized) seizures, and mixed seizure patterns. It is also used as a sedative-hypnotic and an adjunctive therapy for the treatment of pain.

Brand Name	Barbit
Type	Tablet
Weight	30 mg
Generic	Phenobarbital
Manufacturer	Incepta Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Barbit Tablet 30 mg has an encephalodepressant action, possibly via binding to GABAA receptors. This action produces an anxiolytic effect, as well as decreased seizure activity. It also has a tranquilizing effect.

How Long Does It Take to Work?

The onset of action of phenobarbital is rapid, usually within minutes, and the duration of action is typically 12-24 hours.

Absorption

Barbit Tablet 30 mg is rapidly and almost completely absorbed after oral administration, reaching peak serum concentrations within 1-2 hours.

Route of Elimination

Barbit Tablet 30 mg is metabolized in the liver and excreted via the kidneys. Approximately 70-90% of a dose is eliminated in the urine as glucuronide conjugates within 24 hours.

Dosage

Suggested doses of Phenobarbital for specific indications are as follows:

Pediatric Oral Dosage:

Preoperative: 1 mg to 3 mg/kg.
Anticonvulsant: 1 mg to 6 mg/kg per day

Adult Oral Dosage:

Daytime sedative: 30 mg to 120 mg daily in 2 to 3 divided doses.
Bedtime hypnotic: 100 mg to 320 mg.
Anticonvulsant: 50 mg to 100 mg 2 to 3 times daily.

Pediatric Injection Dosage:

15 to 20 mg/kg IV over 10 to 15 min.
Preoperative Sedation:1 to 3 mg/kg IM/IV;
Anticonvulsant: 4 to 6 mg/kg IM/IV per day, for 10 days. Alternatively, use 10 to 15 mg/kg IM/IV per day to reach therapeutic level more quickly. Maxium IV rate 60 mg/min.

Adult Injection Dosage:

Insomnia: 100 to 320 mg IM/IV;
Convulsions: 100 to 320 mg IV. Repeat if needed (maximum, 600 mg per day);
Status Epilepticus: 10 to 20 mg/kg IV. Repeat if needed.

The usual dose for adults is 1.5-3 mg/kg a day in two or three divided doses. The usual dose for children is 2-5 mg/kg a day in two or three divided doses. If the dose is taken twice daily, the dose should be taken at bedtime and at noon for best effects.

Administration

Barbit Tablet 30 mg should be taken orally with a glass of water. It should be taken with food or milk if GI irritation occurs. The tablets should not be crushed, chewed, or dissolved in liquid.

Side Effects

Common side effects of phenobarbital include confusion, drowsiness, dizziness, impaired coordination, headache, nausea, vomiting, blurred vision, and rash. Rarely, phenobarbital can cause an allergic reaction, which may include difficulty breathing, hives, swelling of the face, lips, tongue, or throat.

Toxicity

Overdose of phenobarbital can lead to central nervous system depression, coma, respiratory depression, and death. The symptoms of overdose include confusion, disorientation, slurred speech, tachycardia, and impaired motor coordination.

Precautions

Barbit Tablet 30 mg should be used with caution in patients with liver disease, as the drug is metabolized in the liver. It should also be used with caution in elderly patients, as they may be more sensitive to the drug's effects. It should be used with caution in patients with a history of alcoholism or drug addiction.

Interaction

Barbit Tablet 30 mg may interact with other drugs, including other anticonvulsants, alcohol, antidepressants, and narcotic pain relievers. It may also interact with other substances, such as alcohol, caffeine, and tobacco. These interactions may increase or decrease the effectiveness of the medication.

Disease Interaction

Barbit Tablet 30 mg may interact with certain diseases, including liver and kidney disease, depression, and mental illness. Patients with any of these conditions should consult their healthcare provider before taking this medication.

Drug Interactions

Barbit Tablet 30 mg may interact with other medications, including anticonvulsants, antidepressants, anticholinergics, antiarrhythmics, sedatives/hypnotics, warfarin, and other CNS depressants. Patients should inform their healthcare provider about any medications they are taking before taking phenobarbital.

Food Interactions

Barbit Tablet 30 mg may interact with certain foods, such as alcohol, caffeine, and tobacco. Patients should inform their healthcare provider about any foods they are consuming before taking this medication.

Pregnancy Use

Barbit Tablet 30 mg should not be used during pregnancy unless the benefits outweigh the risks. Patients should inform their healthcare provider if they are pregnant or planning to become pregnant before taking this medication.

Lactation Use

Barbit Tablet 30 mg is excreted in breast milk and may cause undesirable effects in a nursing infant. Patients should inform their healthcare provider if they are breastfeeding before taking this medication.

Acute Overdose

An overdose of phenobarbital can be dangerous and may require immediate medical attention. Symptoms of an overdose include confusion, disorientation, slurred speech, tachycardia, impaired motor coordination, and coma. Patients should seek medical attention immediately if they suspect they have overdosed.

Contraindication

Barbit Tablet 30 mg is contraindicated in patients with allergies to the drug, in patients with severe liver or kidney disease, in those with a history of porphyria, and in those with a history of drug abuse or addiction. Patients should inform their healthcare provider if they have any of these conditions before taking this medication.

Use Direction

Barbit Tablet 30 mg should be taken orally with a glass of water. The tablets should not be crushed, chewed, or dissolved in liquid. The usual dose for adults is 1.5-3 mg/kg a day in two or three divided doses. The usual dose for children is 2-5 mg/kg a day in two or three divided doses. If the dose is taken twice daily, the dose should be taken at bedtime and at noon for best effects.

Storage Conditions

Barbit Tablet 30 mg should be stored at room temperature away from light, heat, and moisture. It should be kept out of the reach of children and pets.