Baclofen

Baclofen

Baclofen is a medication primarily used to treat spasticity, particularly in conditions such as multiple sclerosis and spinal cord injuries. It functions as a muscle relaxer and an antispastic agent.

Brand Name	Baclofen
Type
Weight
Generic	Baclofen
Manufacturer
Available in	English বাংলা

Mechanism of Action

Baclofen works by activating $\text{GABA}_{\text{B}}$ receptors in the brain and spinal cord, which inhibits the release of excitatory neurotransmitters. This action reduces the activity of nerve cells that cause muscle spasticity.

Uses

• Spasticity: Baclofen is effective in reducing muscle stiffness and spasms associated with multiple sclerosis and spinal cord injuries.
• Hiccups: It is sometimes used off-label to treat persistent hiccups.
• Alcohol Withdrawal: Baclofen is also used off-label to manage symptoms of alcohol withdrawal.

Side Effects

Common side effects of Baclofen include:

• Drowsiness
• Dizziness
• Weakness
• Fatigue
• Headache

Dosage

Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily.

Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose-

• 12 month-2 years: 10-20 mg (10-20 ml)
• 2 years-6 years: 20-30 mg (20-30 ml)
• 6 years-10 years: 30-60 mg (30-60 ml)

The dosage of Baclofen varies based on the condition being treated and the patient’s response to the medication. It is typically started at a low dose and gradually increased.

Precautions

• Kidney Function: Baclofen is excreted by the kidneys. Patients with impaired kidney function need dose adjustments.
• Abrupt Withdrawal: Stopping Baclofen suddenly can lead to severe withdrawal symptoms, including seizures.
• Alcohol and CNS Depressants: Concomitant use with alcohol or other CNS depressants can enhance the sedative effects of Baclofen .

How Long Does It Take to Work?

Baclofen typically begins to show its effects within a few days of starting the treatment. However, the full therapeutic effect may take up to a week or more, depending on the dosage and individual response.

Pregnancy Use

Baclofen is classified as a Category C drug for pregnancy. This means that animal studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in humans. Baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Baclofen is excreted in breast milk. Caution is advised if Baclofen is used while breastfeeding, as it may cause sedation and other effects in the nursing infant.

See in details version Baclofen also Baclofen in bangla

Some Frequently Asked Questions About Baclofen